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156256 Sigma-Aldrich

Sodium methoxide solution

25 wt. % in methanol

Synonym: Sodium methylate



Related Categories Essential Chemicals, Materials Science, Micro/NanoElectronics, Research Essentials, Salts,
vapor density   1.1 (vs air)
vapor pressure   50 mmHg ( 20 °C)
  96 mmHg ( 25 °C)
autoignition temp.   878 °F
concentration   25 wt. % in methanol
refractive index   n20/D 1.37
density   0.945 g/mL at 25 °C



1, 2.5 L in glass bottle

18 L in steel drum

25 mL in glass bottle


A novel high-spin hexanuclear Mn(III) cluster, [NaMn6(OMe)12(dbm)6]+, was synthesized via MnCl2 oxidation with simultaneous NaOMe promoted aggregation. This cluster has an unprecedented cyclic structure and 24 unpaired electrons in its ground state.

Sodium methoxide solution has been used in the synthesis of NO-containing nanoparticles (SNO-NP).

General description

The product is 25wt.% solution of sodium methoxide in methanol. Its reaction with unactivated aryl bromides in the presence of copper catalyst under various reaction conditions has been studied. It reacts with aryl halides in the presence of a palladium catalyst in DMF (Dimethylformamide) to afford arenes.

Price and Availability

Safety & Documentation

Safety Information

Signal word 
Supplemental Hazard Statements 
Reacts violently with water.
UN1289 - class 3 - PG 2 - Sodium methylate solutions
WGK Germany 
Flash Point(F) 
51.8 °F
Flash Point(C) 
11 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Determination of Water Content in Sodium methylate Using Karl Fischer Titration

There are a number of compounds which will react with the Karl Fischer reagent and form water. This would allow to titrate those compounds using a KF titration even if they are only a minor side-comp...
Keywords: Karl Fischer titrations, Titrations

GC Determination of Fatty Acids in Infant Formula by AOAC Method 2012.13

The nutritional content of infant formula is considered extremely critical, and thus it is one of the most regulated food products worldwide. Most commercial infant formulas are derived from cow’s mi...
Katherine K Stenerson, Olga I Shimelis, Gary Oshi
Reporter US, Volume 33.4 (Food & Beverage Supplement)
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Hydrogenations, Phase transitions, Sample preparations, Separation, Transesterifications

Peer-Reviewed Papers


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