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156256 Sigma-Aldrich

Sodium methoxide solution

25 wt. % in methanol

Synonym: Sodium methylate



Related Categories Essential Chemicals, Materials Science, Micro/NanoElectronics, Research Essentials, Salts,
vapor density   1.1 (vs air)
vapor pressure   50 mmHg ( 20 °C)
  96 mmHg ( 25 °C)
autoignition temp.   878 °F
concentration   25 wt. % in methanol
refractive index   n20/D 1.37
density   0.945 g/mL at 25 °C



1, 2.5 L in glass bottle

18 L in steel drum

25 mL in glass bottle


A novel high-spin hexanuclear Mn(III) cluster, [NaMn6(OMe)12(dbm)6]+, was synthesized via MnCl2 oxidation with simultaneous NaOMe promoted aggregation. This cluster has an unprecedented cyclic structure and 24 unpaired electrons in its ground state.1

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Sodium methoxide

reagent grade, 95%, powder

Sodium methoxide solution

ACS reagent, 0.5 M CH3ONa in methanol (0.5N)

Safety & Documentation

Safety Information

Signal word 
Supplemental Hazard Statements 
Reacts violently with water.
UN 1289 8(3) / PGII
WGK Germany 
Flash Point(F) 
51.8 °F
Flash Point(C) 
11 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Determination of Water Content in Sodium methylate Using Karl Fischer Titration

There are a number of compounds which will react with the Karl Fischer reagent and form water. This would allow to titrate those compounds using a KF titration even if they are only a minor side-comp...
Keywords: Karl Fischer titrations, Titrations

Peer-Reviewed Papers


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1. Abbati, G.L. et al. Inorg. Chem. 37, 1430, (1998)

Carbohydrate conjugation through microwave-assisted functionalization of single-walled carbon nanotubes using perfluorophenyl azides. Kong N, Shimpi MR, Ramström O, et al. Carbohydr. Res. 405, 33-8, (2015)


Total synthesis of putative montamine and a proposed structural reassignment. Blair LM, Colby Davie EA, Sperry J, et al. Org. Biomol. Chem. 12(35), 6878-84, (2014)


Determination of nonpolar and polar lipid classes in human plasma, erythrocytes and plasma lipoprotein fractions using ultrahigh-performance liquid chromatography-mass spectrometry. Hol?apek M, Cífková E, ?ervená B, et al. J. Chromatogr. A. 1377, 85-91, (2015)


The uptake of trehalose glycolipids by macrophages is independent of Mincle. Kodar K, Eising S, Khan AA, et al. ChemBioChem. 16(4), 683-93, (2015)


Sol-gel synthesis and electrospraying of biodegradable (P2O5)55-(CaO)30-(Na2O)15 glass nanospheres as a transient contrast agent for ultrasound stem cell imaging. Foroutan F, Jokerst JV, Gambhir SS, et al. ACS Nano 9(2), 1868-77, (2015)


Preparing a pseudo-solid by the reinforcement of a polydentate thioether using silver nanoparticles. Pletsch H, Greiner A, Agarwal S, et al. Nanoscale 7(5), 1977-83, (2015)


Nitric oxide-releasing poly(lactic-co-glycolic acid)-polyethylenimine nanoparticles for prolonged nitric oxide release, antibacterial efficacy, and in vivo wound healing activity. Nurhasni H, Cao J, Choi M, et al. Int. J. Nanomedicine 10, 3065-80, (2015)


In vitro anti-influenza virus activities of a new lignan glycoside from the latex of Calotropis gigantea. Parhira S, Yang ZF, Zhu GY, et al. PLoS ONE 9(8), e104544, (2014)


Studies on the collision-induced dissociation of adipoR agonists after electrospray ionization and their implementation in sports drug testing. Dib J, Schlörer N, Schänzer W, et al. J. Mass Spectrom. 50(2), 407-17, (2015)


Hepatocyte-targeting gene delivery using a lipoplex composed of galactose-modified aromatic lipid synthesized with click chemistry. Sakashita M, Mochizuki S, Sakurai K, et al. Bioorg. Med. Chem. 22(19), 5212-9, (2014)


Efficient, scalable and economical preparation of tris(deuterium)- and 13C-labelled N-methyl-N-nitroso-p-toluenesulfonamide (Diazald®) and their conversion to labelled diazomethane. Shields SW, Manthorpe JM, et al. J. Labelled Comp. Radiopharm. 57(12), 674-9, (2014)


Chemical profile and biological activities of Veronica thymoides subsp. pseudocinerea. Ertas A, Boga M, Kizil M, et al. Pharm. Biol. 53(3), 334-9, (2015)


Merck 14,8643

Beil. 1,IV,1220

Fieser 1,1091 / Fieser 2,385 / Fieser 3,259 / Fieser 4,457 / Fieser 5,617 / Fieser 6,545 / Fieser 8,463 / Fieser 9,430 / Fieser 11,489

Aldrich MSDS 1, 1611:D / Corp MSDS 1 (2), 3147:A / IR-Spectra (3), 1556:A / RegBook 1 (2), 3051:I / Sax 6, 2440 / Structure Index 1, 483:C:9

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