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16137 Sigma-Aldrich

8-Bromoadenosine 3′,5′-cyclic monophosphate

≥98.0% (HPLC)

Synonym: 8-Br-A-3:5-MP, 8-Br-cAMP, 8-Bromo-cAMP

  • CAS Number 23583-48-4

  • Empirical Formula (Hill Notation) C10H11BrN5O6P

  • Molecular Weight 408.10

  •  Beilstein Registry Number 591930

  •  EC Number 245-760-6

  •  MDL number MFCD00075580

  •  PubChem Substance ID 329751108

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Properties

Related Categories Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides More...
InChI Key   DVKQVRZMKBDMDH-UUOKFMHZSA-N
assay   ≥98.0% (HPLC)
impurities   ≤1% water
mp   254 °C (dec.)(lit.)
solubility   0.1 M NaOH: soluble50 mg/mL, clear, faintly yellow or pink

Description

Other Notes

8-Bromoadenosine 3′,5′-cyclic monophosphate is a membrane-permeable cAMP analog.

Cyclic nucleotide analog for studying Ca2+- mediated pathways; Potent activator of protein kinase

Sensitive to light and moisture

Biochem/physiol Actions

8-Bromoadenosine 3′,5′-cyclic monophosphate is a cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. 8-Bromoadenosine 3′,5′-cyclic monophosphate activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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B5386 8-Bromoadenosine 3′,5′-cyclic monophosphate, ≥97% (HPLC)

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