16382 Sigma-Aldrich


analytical standard

Synonym: 3−,5-Dihydroxy-3,4−,6,7-tetramethoxyflavone, 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one, 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one, Vitexicarpin

  • CAS Number 479-91-4

  • Empirical Formula (Hill Notation) C19H18O8

  • Molecular Weight 374.34

  •  Beilstein Registry Number 1300392

  •  MDL number MFCD00210481



Related Categories A - D, Achillea, Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography,
grade   analytical standard
assay   ≥98.0% (HPLC)
form   neat
shelf life   limited shelf life, expiry date on the label
format   neat
storage temp.   2-8°C


Other Notes

Same product — same quality — now Sigma-Aldrich brand


Bottomless glass bottle. Contents are inside inserted fused cone.

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Safety & Documentation

Safety Information

WGK Germany 


Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers


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The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action. Haïdara K, Zamir L, Shi QW, et al. Cancer Lett. 242(2), 180-90, (2006)


[Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography]. Guan R, Wang D, Yu Z, et al. Se Pu 28(11), 1043-7, (2010)


[Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell]. Song YC, Zhang X, Lei GY, et al. Zhonghua Yi Xue Za Zhi 90(10), 703-7, (2010)


Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes. de Sampaio e Spohr TC, Stipursky J, Sasaki AC, et al. J. Neurosci. Res. 88(3), 530-41, (2010)


In vivo effect of casticin on acute inflammation. Lin S, Zhang H, Han T, et al. Zhong Xi Yi Jie He Xue Bao 5(5), 573-6, (2007)


[Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway]. Wang HY, Cai B, Cui CB, et al. Yao Xue Xue Bao 40(1), 27-31, (2005)


Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction. Basalo C, Mohn T, and Hamburger M Planta Med. 72(12), 1157-62, (2006)


Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-κB inactivation. Koh DJ, Ahn HS, Chung HS, et al. J. Ethnopharmacol. 136(3), 399-405, (2011)


Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. Han X, Ma X, Zhang T, et al. J. Chromatogr. A. 1151(1-2), 180-2, (2007)


Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. Díaz F, Chávez D, Lee D, et al. J. Nat. Prod. 66(6), 865-7, (2003)


Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Webster DE, He Y, Chen SN, et al. Biochem. Pharmacol. 81(1), 170-7, (2011)


G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). Kobayakawa J, Sato-Nishimori F, Moriyasu M, et al. Cancer Lett. 208(1), 59-64, (2004)


Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells. Yang J, Yang Y, Tian L, et al. World J. Gastroenterol. 17, 4298-4307, (2011)


Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Shen JK, Du HP, Yang M, Wang YG, Jin J. Ann. Hematol. 88, 743-752, (2009)


Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase. Zeng, F. et al. Acta Biochim. Biophys. Sin. (Shanghai) 44, 442-449, (2012)


Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways. Chen, D. et al. Oncol. Rep. 26, 1287-1294, (2011)


Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. Mesaik MA Phytother Res. 23(11), 1516-20, (2009)


Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. Tang SY, Zhong MZ, Yuan GJ, et al. Oncol. Rep. 29(2), 474-80, (2013)


Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro. YE Q, ZHANG QY, ZHENG CJ, et al. Acta Pharmacol. Sin. 31(12), 1564-8, (2010)


Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. Hu Y, Hou TT, Zhang QY, et al. J. Pharm. Pharmacol. 59(9), 1307-12, (2007)


Quantitative determination and pharmacokinetic study of casticin in rat plasma by liquid chromatography-mass spectrometry. Xu J, Zhang Q, Zhao L, et al. J. Pharm. Biomed. Anal. 61, 242-6, (2012)


Metabolism studies of casticin in rats using HPLC-ESI-MS(n). Ling Y, Zhu J, Fan M, et al. Biomed. Chromatogr. 26(12), 1502-8, (2012)


Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. Righeschi C, Eichhorn T, Karioti A, et al. Cancer Genomics Proteomics 9(3), 143-51, (2012)


Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells. Lee SM, Lee YJ, Kim YC, et al. Inflammation 35(2), 584-93, (2012)


The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. Weathers PJ and Towler MJ Planta Med. 78(10), 1024-6, (2012)


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