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17849 Sigma-Aldrich

Enrofloxacin

≥98.0% (HPLC)

Synonym: Baytril

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
InChI Key   SPFYMRJSYKOXGV-UHFFFAOYSA-N
assay   ≥98.0% (HPLC)
form   powder
Mode of action   DNA synthesis | interferes
  enzyme | inhibits

Description

Application

Enrofloxacin has been used:
• to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
• to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
• as an analyte in a chemiluminescence reagent system

General description

Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.

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Laboratory Gloves
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
VB1993650
Protocols & Articles
Peer-Reviewed Papers
15

References

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