186562 Sigma-Aldrich


anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

Synonym: THF



Related Categories Alternative Energy, Anhydrous, Anhydrous Solvents, Electrolytes, Materials Science,
grade   anhydrous
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.9%
autoignition temp.   610 °F
contains   250 ppm BHT as inhibitor
expl. lim.   11.8 %
impurities   ≤0.005% peroxides (as H2O2)
  <0.002% water (All units except 100 mL)
  <0.005% water (100 mL pkg)
refractive index   n20/D 1.407(lit.)
bp   65-67 °C(lit.)
mp   −108 °C(lit.)
solubility   H2O: soluble
density   0.889 g/mL at 25 °C(lit.)


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1, 6×1, 2, 4×2 L in Sure/Seal™

18 L in Pure-Pac™ 1

200 L in Kilo-Lab™

200 L in Pure-Pac™ 1

200 L in Pure-Pac™ 2

200, 208 L in steel drum

400 L in Kilo-Lab™

50 L in Pure-Pac™ 2

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100, 12×100 mL in Sure/Seal™

400 L in Pure-Pac™ 1


Dry tetrahydrofuran (THF) has been used in the synthesis of dichloro{bis[1,1′,1′′-(phosphinetriyl)tripiperidine]}palladium [(P(NC5H10)3)2Pd(Cl)2], which is widely used in the Heck reaction as a catalyst. It has been employed in the reaction medium of the Heck cross-coupling reaction of various aryl bromides and olefins.

General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms double hydrate with hydrogen sulfide, crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.

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Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
UN 2056 3 / PGII
WGK Germany 
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C
Protocols & Articles


Complex Hydrides: A New Category of Solid-state Lithium Fast-ion Conductors

Research and development of solid-state lithium fast-ion conductors is crucial because they can be potentially used as solid electrolytes in all-solid-state batteries, which may solve the safety and ...
Motoaki Matsuo,1 Hiroyuki Oguchi,1,2 Hideki Maekawa,2 Hitoshi Takamura,2Shin-ichi Orimo,1*
Material Matters Volume 5 Article 4
Keywords: Calorimetry, Deposition, Diffraction, Diffusion, Melting, Nuclear magnetic resonance spectroscopy, Raman spectroscopy, Search, Spectra, Spectroscopy, Substitutions, Support, X-Ray diffraction, transformation

Determination of Water Content in Tetrahydrofuran Using Karl Fischer Titration

Ethers behave similarly to hydrocarbons. They are mostly adequately soluble in methanol. Only long chain ethers require the addition of propanol or chloroform as solubilizers. Double bonds can someti...
Keywords: Solvents, Titrations

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Agriculture | Crop Protection Workflow

Pesticides are an essential component in modern agriculture and enable growers to fully realize the yield potential of their seeds. From compound discovery to active ingredient development, our chemi...
Keywords: Agriculture, Pesticides

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