208213 Sigma-Aldrich

Polyphosphoric acid Green Alternative

reagent grade, 115% H3PO4 basis



Related Categories Acids, Acids & Bases, Alternative Energy, Analytical Reagents, Analytical Reagents for General Use,
grade   reagent grade
assay   115% H3PO4 basis
greener alternative product characteristics   Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
bp   300 °C(lit.)
density   2.06 g/mL at 25 °C


Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.


1 kg in poly bottle

100 g in poly bottle

25 g in glass bottle

General description

Sigma Life Science is committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.

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Phosphoric acid

crystalline, ≥99.999% trace metals basis

Polyphosphoric acid

≥83% phosphate (as P2O5) basis

Polyphosphoric acid

~105% H3PO4 basis

Pyrophosphoric acid

technical, ≥90% (T)

Safety & Documentation

Safety Information

GHS05  GHS05
Signal word 
Hazard statements 
Precautionary statements 
UN 3264 8 / PGII
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles

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Peer-Reviewed Papers


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Effect of polyphosphoric acid pre-treatment of titanium on attachment, proliferation, and differentiation of osteoblast-like cells (MC3T3-E1). Maekawa K, Yoshida Y, Mine A, et al. Clin. Oral Implants Res. 19(3), 320-5, (2008)


Calcification of cartilage formed in vitro on calcium polyphosphate bone substitutes is regulated by inorganic polyphosphate. St-Pierre JP, Pilliar RM, Grynpas MD, et al. Acta Biomater. 6(8), 3302-9, (2010)


[Recycling system of ribosomal proteins by Lon protease]. Nomura K, Ohtake H, and Kuroda A Tanpakushitsu Kakusan Koso. 49(7 Suppl), 1069-70, (2004)


Chemical interaction of polyphosphoric acid with titanium and its effect on human bone marrow derived mesenchymal stem cell behavior. Maekawa K, Yoshida Y, Mine A, et al. J. Biomed. Mater. Res. A 82(1), 195-200, (2007)


Synthesis and insect antifeedant activity of aurones against Spodoptera litura larvae. Morimoto M, Fukumoto H, Nozoe T, et al. J. Agric. Food Chem. 55(3), 700-5, (2007)


Polyphosphoric acid treatment promotes bone regeneration around titanium implants. Maekawa K, Shimono K, Oshima M, et al. J. Oral Rehabil. 36(5), 362-7, (2009)


Combined physico-chemical treatments based on enterocin AS-48 for inactivation of Gram-negative bacteria in soybean sprouts. Cobo Molinos A, Abriouel H, López RL, et al. Food Chem. Toxicol. 46(8), 2912-21, (2008)


PPA-mediated C-C bond formation: a synthetic route to substituted indeno[2,1-c]quinolin-6(7H)-ones. Liu X, Zhang Q, Zhang D, et al. Org. Lett. 15(4), 776-9, (2013)


Polyphosphoric acid promoted synthesis of 10,11-dihydrobenzo[j]fluoranthen-12-one. Chang MY, Lee TW, and Wu MH Org. Lett. 14(9), 2198-201, (2012)


Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones. Srinivas Kantevari et al Bioorg. Med. Chem. Lett. 21, 4316-9, (2011)


Polyphosphoric acid trimethylsilyl ester promoted intramolecular acylation of an olefin by a carboxylic acid: convenient construction of C-18-functionalized delta14-hecogenin acetate. Li W and Fuchs PL Org. Lett. 5(22), 4061-4, (2003)


Determination of ceftriaxone sodium in pharmaceutical formulations by flow injection analysis with acid potassium permanganate chemiluminescence detection. Zhang D, Ma Y, Zhou M, et al. Anal. Sci. 22(1), 183-6, (2006)


Ion-pair reverse-phase high-performance liquid chromatography. Application to the study of chicken liver NAD+ kinase. Gabriel MK and McGuinness ET Anal. Biochem. 149(2), 339-43, (1985)


Silica-supported polyphosphoric acid in the synthesis of 4-substituted tetrahydroisoquinoline derivatives. Manolov S, Nikolova S, and Ivanov I Molecules 18(2), 1869-80, (2013)


Cellular formation of DNA and RNA and the relationship to tumour cell development. Robertson DS Med. Hypotheses 62(1), 97-111, (2004)


The MPEG monophosphate ester: synthesis and characterization. Penczek S, Kaluzynski K, Wisniewski B, et al. J. Biomater. Sci. Polym. Ed. 20(14), 2103-16, (2009)


Fieser 1,894 / Fieser 2,334 / Fieser 3,231 / Fieser 4,395 / Fieser 5,540 / Fieser 6,474 / Fieser 7,294 / Fieser 10,321 / Fieser 12,399

Corp MSDS 1 (2), 2885:D / RegBook 1 (3), 3249:A

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