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2106 Sigma-Aldrich

Heparin sodium salt from porcine intestinal mucosa

endotoxin, free

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Properties

Related Categories Biochemicals and Reagents, Carbohydrates, Carbohydrates A to Z, Carbohydrates H-L, Core Bioreagents,
usage   sufficient for 5 mL blood anticoagulant
packaging   preweighed vial of 300 USP units
impurities   endotoxin, free
solubility   water: soluble50 g/L
  acetone: insoluble
  alcohol: insoluble
  benzene: insoluble
  chloroform: insoluble
  diethyl ether: insoluble
compatibility   for use with E-Toxate

Description

Caution

Not for injection.

Application

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.

Biochem/physiol Actions

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.

Legal Information

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

Price and Availability


Available in ELITE Grade
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
MI0850000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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