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21186 Sigma-Aldrich

Calcium ionophore III

Selectophore, function tested

Synonym: Antibiotic A 23187, Calcium Ionophore A23187, Calimycin

  • CAS Number 52665-69-7

  • Empirical Formula (Hill Notation) C29H37N3O6

  • Molecular Weight 523.62

  •  Beilstein Registry Number 1096801

  •  EC Number 258-084-1

  •  MDL number MFCD00151202

  •  PubChem Substance ID 329752113

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Properties

Related Categories A - K, Analytical/Chromatography, Antibacterial, Antibiotics, Antibiotics A to Z,
grade   Selectophore
InChI Key   HIYAVKIYRIFSCZ-CYEMHPAKSA-N
quality   function tested
Mode of action   cell membrane | interferes
storage temp.   2-8°C

Description

Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca2+ dependent K+ channels as the K+ efflux.

Other Notes

Preparation of an optical chemical sensor for Ca2+ and Mg2+

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

General description

Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca2+ ions across membranes along a concentration gradient.

Legal Information

Selectophore is a trademark of Sigma-Aldrich Chemie GmbH

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DM4676000
Protocols & Articles
Peer-Reviewed Papers
15

References

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