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227056 Sigma-Aldrich

N,N-Dimethylformamide

anhydrous, 99.8%

Synonym: DMF

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Properties

Related Categories Anhydrous, Anhydrous Solvents, Products, Returnable Containers, Solvent Bottles,
grade   anhydrous
vapor density   2.5 (vs air)
vapor pressure   2.7 mmHg ( 20 °C)
assay   99.8%
autoignition temp.   833 °F
expl. lim.   15.2 %
impurities   <0.005% water
evapn. residue   <0.0005%
refractive index   n20/D 1.430(lit.)
bp   153 °C(lit.)
mp   −61 °C(lit.)
density   0.944 g/mL(lit.)

Description

Application

Solvent for many hydrophobic organic compounds.

Packaging

1, 6×1, 2, 4×2 L in Sure/Seal™

View returnable container options.

100, 12×100 mL in Sure/Seal™

18, 200 L in Pure-Pac™ 1

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45
RIDADR 
UN 2265 3 / PGIII
WGK Germany 
2
RTECS 
LQ2100000
Flash Point(F) 
136.4 °F
Flash Point(C) 
58 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in N,N-Dimethyl formamide Using Karl Fischer Titration

N,N-Dimethyl formamide is occasionally described as a solvent used in the working medium of the KF titration to aid solubility of certain samples, for example in the pharmacopoeia. In the presence of...
Keywords: Solvents, Titrations

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Peer-Reviewed Papers

References

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Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles. Moyer TP, Charlson JR, Enger RJ, et al. Clin. Chem. 48(9), 1460-71, (2002)

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Mass spectrometric evaluation of neuropeptidomic profiles upon heat stabilization treatment of neuroendocrine tissues in crustaceans. Sturm RM, Greer T, Woodards N, et al. J. Proteome Res. 12(2), 743-52, (2013)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins. Rajesh G Kalkhambkar et al Eur. J. Med. Chem. 43, 2178-88, (2008)

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Butyl methacrylate based monoliths with different cross-linking agents using DMF-aqueous buffer as porogen. Gölgelioğlu C and Tuncel A Electrophoresis 34(2), 331-42, (2013)

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Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography/tandem mass spectrometry. Schettgen T, Musiol A, and Kraus T Rapid Commun. Mass Spectrom. 22(17), 2629-38, (2008)

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Radioiodination of aryl-alkyl cyclic sulfates. Mushti C and Papisov MI Molecules 17(11), 13266-74, (2012)

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Antibacterial effect of some benzopyrone derivatives. Rehab Amin et al Eur. J. Med. Chem. 45, 372-8, (2010)

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Three-channel fluorescent sensing via organic white light-emitting dyes for detection of hydrogen sulfide in living cells. Wang J, Lin W, and Li W Biomaterials 34(30), 7429-36, (2013)

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Absorption spectra of PTCDI: a combined UV-Vis and TD-DFT study. Oltean M, Calborean A, Mile G, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97, 703-10, (2012)

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Highly efficient vinylaromatics generation via iron-catalyzed sp3 C-H bond functionalization CDC reaction: a novel approach to preparing substituted benzo[α]phenazines. Lou SJ, Xu DQ, Shen DF, et al. Chem. Commun. (Camb.) 48(98), 11993-5, (2012)

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Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide. Shieh DB, Chen CC, Shih TS, et al. Chem. Biol. Interact. 165(3), 211-9, (2007)

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Syntheses, crystal structure and luminescent properties of cadmium complexes based on 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine. Liu SG, Zhang LP, Liu J, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97, 464-9, (2012)

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X-ray diffraction and infrared spectroscopy of N,N-dimethylformamide and dimethyl sulfoxide solvatomorphs of betulonic acid. Boryczka S, Jastrzebska M, Bębenek E, et al. J. Pharm. Sci. 101(12), 4458-71, (2012)

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Regioselectivity in Sonogashira synthesis of 6-(4-nitrobenzyl)-2-phenylthiazolo[3,2-b]1,2,4-triazole: a quantum chemistry study. Hosseinnejad T, Heravi MM, and Firouzi R J. Mol. Model. 19(2), 951-61, (2013)

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New tetradentate Schiff bases of 2,2-dimethyl-1,3-diaminopropane and acetylacetone derivatives and their vanadyl complexes. Mohammadi K and Rastegari M Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97, 711-6, (2012)

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Microwave assisted synthesis of 2,2'-arylene-substituted bis(4H-3,1-benzoxazin-4-one) derivatives using the complex cyanuric chloride/N,N-dimethylformamide. Shariat M, Samsudin MW, and Zakaria Z Molecules 17(10), 11607-15, (2012)

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Synthesis, spectroscopy, magnetic and redox behaviors of copper(II) complexes with tert-butylated salen type ligands bearing bis(4-aminophenyl)ethane and bis(4-aminophenyl)amide backbones. Kasumov VT, Yerli Y, Kutluay A, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 104, 203-12, (2013)

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A single-step extraction method for the determination of nicotine and cotinine in Jordanian smokers' blood and urine samples by RP-HPLC and GC-MS. Massadeh AM, Gharaibeh AA, and Omari KW J. Chromatogr. Sci. 47(2), 170-7, (2009)

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Effect of acute exposure of N,N-dimethylformamide, an industrial solvent on lipid peroxidation and antioxidants in liver and kidney of rats. Jyothi K, Kalyani D, and Nachiappan V Indian J. Biochem. Biophys. 49(4), 279-84, (2012)

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Short-term exposure to dimethylformamide and the impact on digestive system disease: an outdoor study for volatile organic compound. Wang C, Huang C, Wei Y, et al. Environ. Pollut. 190, 133-8, (2014)

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Synthesis of bis-acyclonucleoside analogues bearing benzothienyl-1,2,4-Triazol-3-Yl-disulfide under conventional and microwave methods. Aouad MR, Rezki N, Messali M, et al. Nucleosides Nucleotides Nucleic Acids 32(1), 28-41, (2013)

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A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF. Xu X, Zhang M, Jiang H, et al. Org. Lett. 16(13), 3540-3, (2014)

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Merck 14,3243

Beil. 4,IV,171

Fieser 1,273 / Fieser 1,278 / Fieser 2,153 / Fieser 3,115 / Fieser 4,184 / Fieser 5,247 / Fieser 7,124 / Fieser 8,189 / Fieser 9,182 / Fieser 11,198 / Fieser 12,203 / Fieser 14,148 / Fieser 16,144

Aldrich MSDS 1, 770:A / Corp MSDS 1 (1), 1374:A / FT-IR 2 (1), 1278:A / FT-IR 1 (1), 758:D / FT-NMR 1 (1), 1239:C / IR-Spectra (3), 443:E / IR-Spectra (2), 392:D / IR-Spectra (3), 443:D / NMR-Reference 2 (1), 639:A / RegBook 1 (1), 891:A / Sax 6, 1163 / Sigma FT-IR 1 (2), 500:D / Structure Index 1, 136:D:7 / Vapor Phase 3, 781:B

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