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25328 Sigma-Aldrich

4-Chloro-1-naphthol

for analytical purposes, ≥99.0%

  • CAS Number 604-44-4

  • Linear Formula ClC10H6OH

  • Molecular Weight 178.61

  •  Beilstein Registry Number 509750

  •  EC Number 210-068-5

  •  MDL number MFCD00003974

  •  PubChem Substance ID 24855304

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates,
grade   for analytical purposes
InChI Key   LVSPDZAGCBEQAV-UHFFFAOYSA-N
assay   ≥99.0% (HPLC)
  ≥99.0%
mp   118-120 °C
  118-121 °C(lit.)
solubility   methanol: soluble50 mg/mL, clear, colorless to very faintly yellow
fluorescence   λex 310 nm; λem 375 nm in ethanol

Description

Other Notes

Peroxidase stain. In the detection of specific antigens after isoelectric focusing and immunoblotting into nitrocellulose membranes; In a dot-immunobinding assay for the detection and quantitation of human IgE; A rapid multicolor Western blot

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Application

4-chloro-1-naphthol along with N,N′-dimethyl-p-phenylendiamine may be used in an oxidative coupling reaction for visualization of antigen-antibody complexes on the nitrocellulose membrane. 4-Chloro-1-naphthol may also be used in scanning electrochemical microscopy (SECM), for imaging of DNA hybridization on microscopic polypyrrole patterns. It was used in immunoblotting analysis during purification of native specific proteins of Taenia crassiceps cysticerci antigens obtained by immunoaffinity chromatography.

General description

4-Chloro-1-naphthol is primarily used for the detection of proteins, it gives a characteristic purple precipitate and the reactions are easily controllable. It can be used as a substitute for benzidine compounds, which are considered to be carcinogenic.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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