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258148 Sigma-Aldrich

Hydrochloric acid

ACS reagent, 37%

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Properties

Related Categories ACS Grade Acids & Bases, Acids, Acids & Bases, Acids and Bases, Analytical Reagents,
grade   ACS reagent
vapor density   1.3 (vs air)
vapor pressure   3.23 psi ( 21.1 °C)
  7.93 psi ( 37.7 °C)
assay   36.5-38.0% (ACS specification)
  37%
impurities   ≤1 ppm free chlorine
  ≤5 ppm extractable organic substances
ign. residue   ≤5 ppm
color   APHA: ≤10, free from suspended matter or sediment
bp   >100 °C(lit.)
density   1.2 g/mL at 25 °C(lit.)
anion traces   bromide (Br-): ≤0.005%
  sulfate (SO42-): ≤1 ppm
  sulfite (SO32-): ≤1 ppm
cation traces   As: ≤0.01 ppm
  Fe: ≤0.2 ppm
  NH4+: ≤3 ppm
  heavy metals (as Pb): ≤1 ppm

Description

Other Notes

ACS specifications same as product 320331

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

Packaging

2.5 L in poly bottle

2.5 L-GL in glass bottle

25, 100, 4×100, 12×100 mL in glass bottle

500 mL in poly bottle

500 mL-GL in glass bottle

6×2.5 L-GL in glass bottle

6×2.5, 4, 4×4 L in poly bottle

6×500 mL in poly bottle

6×500 mL-GL in glass bottle

Single 2.5L-GL units require a can opener to open the metal shipping container.

Application

Chlorine source for safer, greener chlorination of aromatic compounds and a,b-unsaturated carbonyl compounds.

Highly Selective Oxidative Monochlorination To Synthesize Organic Intermediates: 2-Chlorotoluene, 2-Chloroaniline, 2-Chlorophenol, and 2-Chloro-4-methylphenol

A Convenient Halogenation of α,β-Unsaturated Carbonyl Compounds with OXONE® and Hydrohalic Acid (HBr, HCl)

Legal Information

OXONE is a registered trademark of E. I. du Pont de Nemours and Company

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1789 8 / PGII
WGK Germany 
1
RTECS 
MW4025000
Protocols & Articles

Articles

Determination of Water Content in Hydrochloric acid 32% Using Karl Fischer Titration

Strong acids shift the pH of the KF reagent and must be neutralized. This can be carried out directly in the titration cell providing a sufficient amount of buffer is added, e.g. HYDRANAL-Buffer Acid...
Keywords: Esterifications, Titrations

Determination of Water Content in Hydrochloric acid, anhydrous Using Karl Fischer Titration

Strong acids shift the pH of the KF reagent and must be neutralized. This can be carried out directly in the titration cell providing a sufficient amount of buffer is added, e.g. HYDRANAL-Buffer Acid...
Keywords: Esterifications, Titrations

Determination of Water Content in Hydrochloric-acid (in 1-Butanol 3 mol/l) Using Karl Fischer Titration

Strong acids shift the pH of the KF reagent and must be neutralized. This can be carried out directly in the titration cell providing a sufficient amount of buffer is added, e.g. HYDRANAL-Buffer Acid...
Keywords: Esterifications, Titrations

Protocols

Enzymatic Assay of Neuraminidase

2.1. This procedure applies to products that have a specification for neuraminidase content by enzymatic determination.

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Molarity Calculator and Normality Calculator for Acids and Bases

The molarity calculator tool provides lab-ready directions describing how to prepare an acid or base solution of specified Molarity (M) or Normality (N) from a concentrated acid or base solution.  To...

Peer-Reviewed Papers

References

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Acoustic-frequency vibratory stimulation regulates the balance between osteogenesis and adipogenesis of human bone marrow-derived mesenchymal stem cells. Chen X, He F, Zhong DY, et al. Biomed Res. Int. 2015, 540731, (2015)

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The biocompatibility of degradable magnesium interference screws: an experimental study with sheep. Thormann U, Alt V, Heimann L, et al. Biomed Res. Int. 2015, 943603, (2015)

Loading...


Exercise-induced neuroprotection in the spastic Han Wistar rat: the possible role of brain-derived neurotrophic factor. Van Kummer BH, Cohen RW, et al. Biomed Res. Int. 2015, 834543, (2015)

Loading...


Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in patients with peripheral arterial disease. Kunisawa T, Yamagishi A, Suno M, et al. Ther. Clin. Risk Manag. 11, 107-14, (2015)

Loading...


The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster. Bretscher AJ, Honti V, Binggeli O, et al. Biol. Open 4(3), 355-63, (2015)

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Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases. Kanno A, Tanimura N, Ishizaki M, et al. Nat. Commun. 6, 6119, (2015)

Loading...


Dopamine antagonism decreases willingness to expend physical, but not cognitive, effort: a comparison of two rodent cost/benefit decision-making tasks. Hosking JG, Floresco SB, Winstanley CA, et al. Neuropsychopharmacology 40(4), 1005-15, (2015)

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Surface modification-induced phase transformation of hexagonal close-packed gold square sheets. Fan Z, Huang X, Han Y, et al. Nat. Commun. 6, 6571, (2015)

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BEL1-LIKE HOMEODOMAIN6 and KNOTTED ARABIDOPSIS THALIANA7 interact and regulate secondary cell wall formation via repression of REVOLUTA. Liu Y, You S, Taylor-Teeples M, et al. Plant Cell 26(12), 4843-61, (2015)

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SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease. Brinkmalm A, Brinkmalm G, Honer WG, et al. Molecular Neurodegeneration 9, 53, (2014)

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Invincible DNA tethers: covalent DNA anchoring for enhanced temporal and force stability in magnetic tweezers experiments. Janissen R, Berghuis BA, Dulin D, et al. Nucleic Acids Res. 42(18), e137, (2014)

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On the role of adenosine (A)?A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats. Wydra K, Go?embiowska K, Suder A, et al. Psychopharmacol. Ser. 232(2), 421-35, (2015)

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?-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. Sadeghi M, Tzschentke TM, Christie MJ, et al. Br. J. Pharmacol. 172(2), 460-8, (2014)

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Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA. Theler D, Dominguez C, Blatter M, et al. Nucleic Acids Res. 42(22), 13911-9, (2014)

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Adriamycin-induced nephropathy in rats: functional and cellular effects characterized by MRI. Egger C, Cannet C, Gérard C, et al. J. Magn. Reson. Imaging 41(3), 829-40, (2015)

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Detection of human polyomavirus 7 in human thymic epithelial tumors. Rennspiess D, Pujari S, Keijzers M, et al. J. Thorac. Oncol. 10(2), 360-6, (2015)

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Formal recycling of e-waste leads to increased exposure to toxic metals: an occupational exposure study from Sweden. Julander A, Lundgren L, Skare L, et al. Environ. Int. 73, 243-51, (2014)

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[(68)Ga]PSMA-HBED uptake mimicking lymph node metastasis in coeliac ganglia: an important pitfall in clinical practice. Krohn T, Verburg FA, Pufe T, et al. Eur. J. Nucl. Med. Mol. Imaging 42(2), 210-4, (2015)

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Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair. Quinlan E, Partap S, Azevedo MM, et al. Biomaterials 52, 358-66, (2015)

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Tracking targeted bimodal nanovaccines: immune responses and routing in cells, tissue, and whole organism. Cruz LJ, Tacken PJ, Zeelenberg IS, et al. Mol. Pharm. 11(12), 4299-313, (2014)

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Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease. Bäck S, Peränen J, Galli E, et al. Brain Behav. 3(2), 75-88, (2013)

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Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging. Goldstein R, Sosabowski J, Livanos M, et al. Eur. J. Nucl. Med. Mol. Imaging 42(2), 288-301, (2015)

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Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease. Gratuze M, Noël A, Julien C, et al. Hum. Mol. Genet. 24(1), 86-99, (2014)

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Mosaicism for dominant collagen 6 mutations as a cause for intrafamilial phenotypic variability. Donkervoort S, Hu Y, Stojkovic T, et al. Hum. Mutat. 36(1), 48-56, (2015)

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A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells. Fujita T, Kitaura F, Fujii H, et al. PLoS ONE 10(1), e0116579, (2015)

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Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas. Dubbelman AC, Rosing H, Nijenhuis C, et al. Invest. New Drugs 33(1), 233-40, (2015)

Loading...


Inhibition of angiogenesis by antioxidant micelles. Moriyama M, Metzger S, van der Vlies AJ, et al. Adv. Healthc. Mater. 4(4), 569-75, (2015)

Loading...


Modulating drug release from gastric-floating microcapsules through spray-coating layers. Lee WL, Tan JW, Tan CN, et al. PLoS ONE 9(12), e114284, (2014)

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Aniline-modified porous graphitic carbon for hydrophilic interaction and attenuated reverse phase liquid chromatography. Iverson CD, Lucy CA, et al. J. Chromatogr. A. 1373, 17-24, (2014)

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Carbohydrate conjugation through microwave-assisted functionalization of single-walled carbon nanotubes using perfluorophenyl azides. Kong N, Shimpi MR, Ramström O, et al. Carbohydr. Res. 405, 33-8, (2015)

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Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Liou GY, Döppler H, Braun UB, et al. Nat. Commun. 6, 6200, (2015)

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A highly efficient polysulfide mediator for lithium-sulfur batteries. Liang X, Hart C, Pang Q, et al. Nat. Commun. 6, 5682, (2015)

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Phenolic and carotenoid profiles and antiproliferative activity of foxtail millet. Zhang LZ, Liu RH, et al. Food Chem. 174, 495-501, (2014)

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The crystallinity of cellulose controls the physical distribution of sorbed water and the capacity to present water for chemical degradation of a solid drug. Höckerfelt MH, Alderborn G, et al. Int. J. Pharm. 477(1-2), 326-33, (2014)

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Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction. Bär C, Bernardes de Jesus B, Serrano R, et al. Nat. Commun. 5, 5863, (2014)

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Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy. Scialabba C, Licciardi M, Mauro N, et al. Eur. J. Pharm. Biopharm. 88(3), 695-705, (2014)

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Lipophilic prodrug of paclitaxel: interaction with a dimyristoylphosphatidylcholine monolayer. Giuffrida MC, Dosio F, Castelli F, et al. Int. J. Pharm. 475(1-2), 624-31, (2014)

Loading...


Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1. Dong F, Mo Z, Eid W, et al. PLoS ONE 9(11), e113789, (2014)

Loading...


Chitosan/glucose 1-phosphate as new stable in situ forming depot system for controlled drug delivery. Supper S, Anton N, Boisclair J, et al. Eur. J. Pharm. Biopharm. 88(2), 361-73, (2014)

Loading...


Positive-charged solid lipid nanoparticles as paclitaxel drug delivery system in glioblastoma treatment. Chirio D, Gallarate M, Peira E, et al. Eur. J. Pharm. Biopharm. 88(3), 746-58, (2015)

Loading...


Birnessite-type MnO2 nanosheets with layered structures under high pressure: elimination of crystalline stacking faults and oriented laminar assembly. Sun Y, Wang L, Liu Y, et al. Small 11(3), 300-5, (2015)

Loading...


Substrate stress relaxation regulates cell spreading. Chaudhuri O, Gu L, Darnell M, et al. Nat. Commun. 6, 6364, (2015)

Loading...


Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs. Wu W, Ichihara G, Hashimoto N, et al. Int. J. Mol. Sci. 16(1), 660-76, (2015)

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Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Bender M, Giannini S, Grozovsky R, et al. Blood 125(6), 1014-24, (2015)

Loading...


The commonly used antimicrobial additive triclosan is a liver tumor promoter. Yueh MF, Taniguchi K, Chen S, et al. Proc. Natl. Acad. Sci. U. S. A. 111(48), 17200-5, (2014)

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Electrocatalytic and photocatalytic hydrogen production from acidic and neutral-pH aqueous solutions using iron phosphide nanoparticles. Callejas JF, McEnaney JM, Read CG, et al. ACS Nano 8(11), 11101-7, (2014)

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Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Tian R, Wang H, Gish GD, et al. Proc. Natl. Acad. Sci. U. S. A. 112(13), E1594-603, (2015)

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PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Yang Y, Hadjikyriacou A, Xia Z, et al. Nat. Commun. 6, 6428, (2015)

Loading...


DNase II-dependent DNA digestion is required for DNA sensing by TLR9. Chan MP, Onji M, Fukui R, et al. Nat. Commun. 6, 5853, (2015)

Loading...


N-nitrosodimethylamine (NDMA) formation at an indirect potable reuse facility. Sgroi M, Roccaro P, Oelker GL, et al. Water Res. 70, 174-83, (2015)

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Merck 14,4794 / Merck 14,4780

Fieser 4,450 / Fieser 5,333 / Fieser 6,283

Aldrich MSDS 1, 1048:B / Corp MSDS 1 (1), 1892:D / RegBook 1 (3), 3253:A / RegBook 1 (3), 3251:J / Sax 6, 1545

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