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26454 Sigma-Aldrich

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

Synonym: Stearic acid magnesium salt

  • CAS Number 557-04-0

  • Linear Formula [CH3(CH2)16CO2]2Mg

  • Molecular Weight 591.24

  •  Beilstein Registry Number 3919702

  •  EC Number 209-150-3

  •  MDL number MFCD00036391

  •  PubChem Substance ID 24856025

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Properties

Related Categories Analytical/Chromatography, Building Blocks, Carbonyl Compounds, Carboxylic Acid Salts, Chemical Synthesis,
InChI Key   HQKMJHAJHXVSDF-UHFFFAOYSA-L
grade   puriss.
assay   ≥40% stearic acid basis (GC)
  ≥90% stearic and palmitic acid basis
  4.0-5.0% Mg basis (calc on dry sub.)
quality   meets analytical specification of Ph. Eur., BP
impurities   acidity or alkalinity, complies
  microbiological impurity, in accordance
  residual solvents, complies
loss   ≤6.0% loss on drying, 105 °C
mp   200 °C(lit.)
acid value   195‑210(fatty acid)
solubility   alcohol: insoluble
  diethyl ether: insoluble
  water: insoluble
anion traces   chloride (Cl-): ≤1000 mg/kg
  sulfate (SO42-): ≤5000 mg/kg
cation traces   Cd: ≤3 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤10 mg/kg
suitability   in accordance for fatty acid composition
  passes test for identity

Description

Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Biochem/physiol Actions

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
nwg
RTECS 
WI4390000
Protocols & Articles
Peer-Reviewed Papers
15

References

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