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270997 Sigma-Aldrich

Dichloromethane

anhydrous, ≥99.8%, contains 50-150 ppm amylene as stabilizer

Synonym: DCM, Methylene chloride

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Properties

Related Categories Anhydrous, Anhydrous Solvents, Dichloromethane (Methylene chloride), Products, Returnable Containers,
grade   anhydrous
vapor density   2.9 (vs air)
vapor pressure   24.45 psi ( 55 °C)
  6.83 psi ( 20 °C)
  6.86 psi ( 20 °C)
assay   ≥99.8%
autoignition temp.   1223 °F
contains   50-150 ppm amylene as stabilizer
expl. lim.   22 %
impurities   ≤0.001% water
  ≤0.005% water (100 mL pkg)
evapn. residue   <0.0005%
refractive index   n20/D 1.424(lit.)
bp   39.8-40 °C(lit.)
mp   −97 °C(lit.)
density   1.325 g/mL at 25 °C(lit.)

Description

Packaging

1, 6×1, 2, 4×2 L in Sure/Seal™

View returnable container options.

100, 12×100 mL in Sure/Seal™

18, 200 L in Pure-Pac™ 1

Price and Availability

A Greener Alternative to Dichloromethane


A Greener Alternative to DichloromethaneLooking for a greener alternative to dichloromethane (CH2Cl2) in HPLC and
flash chromatography applications?
Consider the greener non-chlorinated alternative, Ethyl acetate/Ethanol 3:1 (v/v) solution (Cat. No. 745588).



Greener/Safer Solvent Dispensing Options


Returnable ContainersOur wide selection of solvents are
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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Blood, Central nervous system, Liver
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
23-24/25-36/37
RIDADR 
UN 1593 6.1 / PGIII
WGK Germany 
2
RTECS 
PA8050000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Dichloromethane Using Karl Fischer Titration

The determination of water in halogenated hydrocarbons is simple and in most cases straightforward. Solubility in methanol is good and the use of 1-propanol or chloroform is only necessary in the cas...
Keywords: Pharmaceutical, Titrations

Determination of Water Content in Dichloromethane, free chlorine Using Karl Fischer Titration

The determination of water in halogenated hydrocarbons is simple and in most cases straightforward. Solubility in methanol is good and the use of 1-propanol or chloroform is only necessary in the cas...
Keywords: Titrations

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Peer-Reviewed Papers

References

Set your institution to view full text papers.

Ligand contributions to the electronic structures of the oxidized cobalt(II) salen complexes. Kochem A, Kanso H, Baptiste B, et al. Inorg. Chem. 51(20), 10557-71, (2012)

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Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane. Kumagai S, Kurumatani N, Arimoto A, et al. Occup. Environ. Med. 70(7), 508-10, (2013)

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Including exposure variability in the life cycle impact assessment of indoor chemical emissions: the case of metal degreasing. Golsteijn L, Huizer D, Hauck M, et al. Environ. Int. 71, 36-45, (2014)

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PGSE NMR diffusion overhauser studies on [Ru(Cp*)(eta6-arene)][PF6], plus a variety of transition-metal, inorganic, and organic salts: an overview of ion pairing in dichloromethane. Moreno A, Pregosin PS, Veiros LF, et al. Chemistry 14(18), 5617-29, (2008)

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Enhanced deep-blue emission from Pt(II) complexes bound to 2-pyridyltetrazolate and an ortho-xylene-linked bis(NHC)cyclophane. MaGee KD, Wright PJ, Muzzioli S, et al. Dalton Trans. 42(12), 4233-6, (2013)

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Methylene chloride toxicity. Am. Fam. Physician 47(5), 1159-66, (1993)

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Microbes, enzymes and genes involved in dichloromethane utilization. Leisinger T, Bader R, Hermann R, et al. Biodegradation 5(3-4), 237-48, (1994)

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Methylene chloride poisoning: a paradigmatic review. Rioux JP and Myers RA J. Emerg. Med. 6(3), 227-38, (1988)

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[Cholangiocarcinoma developing in printing company workers: a new type of occupational cancer]. Kubo S, Takemura S, Sakata C, et al. Gan To Kagaku Ryoho. 40(11), 1451-4, (2013)

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[Potentiometric glucose determination in human serum samples with glucose oxidase biosensor based on iodide electrode]. Karakus E, Pekyardimchi Sh, and Kilich E Prikl. Biokhim. Mikrobiol. 49(2), 209-14, (2013)

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[Aerobic methylobacteria as the basis for a biosensor for dichloromethane detection]. Plekhanova IuV, Firsova IuE, Doronina NV, et al. Prikl. Biokhim. Mikrobiol. 49(2), 203-8, (2013)

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Chiral separations by HPLC on immobilized polysaccharide chiral stationary phases. Ali I, Al-Othman ZA, and Aboul-Enein HY Methods Mol. Biol. 970, 127-35, (2013)

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[Functional analysis of the genome fragment involved in aerobic dichloromethane degradation by methylobacterium dichloromethanicum DM4]. Firsova IuE, Fedorov DN, and Trotsenko IuA Prikl. Biokhim. Mikrobiol. 48(5), 516-21, (2012)

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[Is dichloromethane an occupational carcinogen?]. Soćko R and Kupczewska-Dobecka M Med. Pr. 58(2), 143-53, (2007)

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Dichloromethane. IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 1, 251-315, (1999)

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Aromatic difluoroboron β-diketonate complexes: effects of π-conjugation and media on optical properties. Xu S, Evans RE, Liu T, et al. Inorg. Chem. 52(7), 3597-610, (2013)

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Phylogeny poorly predicts the utility of a challenging horizontally transferred gene in Methylobacterium strains. Michener JK, Vuilleumier S, Bringel F, et al. J. Bacteriol. 196(11), 2101-7, (2014)

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Polyphosphates and pyrophosphates of hexopyranoses as allosteric effectors of human hemoglobin: synthesis, molecular recognition, and effect on oxygen release. Fylaktakidou KC, et al. ChemMedChem 6(1), 153-68, (2011)

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The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. Brent K Rubio et al J. Nat. Prod. 72, 218-22, (2009)

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Activation of dichloromethane by a V(III) thiolate complex: an example of S-based nucleophilic reactivity in an early transition metal thiolate. Chen TT, Chen YS, Chang YH, et al. Chem. Commun. (Camb.) 49(11), 1109-11, (2013)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Removal of dichloromethane from ground and wastewater: a review. Shestakova M and Sillanpää M Chemosphere 93(7), 1258-67, (2013)

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Methylene chloride. Dhillon S and Von Burg R J. Appl. Toxicol. 15(4), 329-35, (1995)

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Incorporating biological information in quantitative risk assessment: an example with methylene chloride. Clewell HJ Toxicology 102(1-2), 83-94, (1995)

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Development of a simultaneous extraction and cleanup method for pyrethroid pesticides from indoor house dust samples. Van Emon JM and Chuang JC Anal. Chim. Acta 745, 38-44, (2012)

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Cytotoxic and genotoxic potential of tannery waste contaminated soils. Masood F and Malik A Sci. Total Environ. 444, 153-60, (2013)

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Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals. Ilaria Massarelli et al Eur. J. Med. Chem. 44, 3658-64, (2009)

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Biodegradation of dichloromethane along with other VOCs from pharmaceutical wastewater. Priya VS and Philip L Appl. Biochem. Biotechnol. 169(4), 1197-218, (2013)

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Use of quantitative modelling in methylene chloride risk assessment. Rhomberg L Toxicology 102(1-2), 95-114, (1995)

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Insights from epidemiology into dichloromethane and cancer risk. Cooper GS, Scott CS, and Bale AS Int. J. Environ. Res. Public Health 8(8), 3380-98, (2011)

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Methylene chloride induced mouse liver and lung tumours: an overview of the role of mechanistic studies in human safety assessment. Green T Hum. Exp. Toxicol. 16(1), 3-13, (1997)

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Voltammetric determination of β-carotene in raw vegetables and berries in Triton X100 media. Ziyatdinova G, Ziganshina E, and Budnikov H Talanta 99, 1024-9, (2012)

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Critical review of the epidemiology literature on the potential cancer risks of methylene chloride. Dell LD, Mundt KA, McDonald M, et al. Int. Arch. Occup. Environ. Health 72(7), 429-42, (1999)

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Heme oxygenase 1-generated carbon monoxide and biliverdin attenuate the course of experimental necrotizing pancreatitis. Nuhn P, Mitkus T, Ceyhan GO, et al. Pancreas 42(2), 265-71, (2013)

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Unprecedented spirocyclization of 3-methyleneindoline-2-thiones during hydrolysis of the phytoalexin cyclobrassinin. Pedras MS, Abdoli A, Chumala PB, et al. Bioorg. Med. Chem. Lett. 23(2), 484-7, (2013)

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Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts. Pan Y, Tiong KH, Abd-Rashid BA, et al. J. Ethnopharmacol. 143(2), 586-91, (2012)

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An analysis of OSHA inspections assessing contaminant exposures in general medical and surgical hospitals. Knight JL, Sleeth DK, Larson RR, et al. Workplace Health Saf. 61(4), 153-60, (2013)

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Bioactive constituents of Salvia chrysophylla Stapf. Çulhaoğlu B, Yapar G, Dirmenci T, et al. Nat. Prod. Res. 27(4-5), 438-47, (2013)

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Multinuclear palladium(II) complexes from P-C and P-Cl bond cleavage in (R(P),R(P)/S(P),S(P))-[PdCl2{1,2-(P(t)BuCl)2C2B10H10}]. Maulana I, Lönnecke P, and Hey-Hawkins E Chem. Commun. (Camb.) 48(82), 10231-3, (2012)

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Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates. Chen JJ, et al. PLoS ONE 4(3), e4949, (2009)

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Use of dichloromethane for preparative supercritical fluid chromatographic enantioseparations. Miller L J. Chromatogr. A 1363, 323-30, (2014)

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Occupational exposure to methylene chloride and risk of cancer: a meta-analysis. Liu T, Xu QE, Zhang CH, et al. Cancer Causes Control 24(12), 2037-49, (2013)

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Structure simulation of ultrathin dichloromethane layer on a solid substrate by density functional theory and molecular dynamics simulations. Zubkov VV and Komarov PV J. Chem. Phys. 137(7), 074705, (2012)

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HPLC analysis and cytotoxic activity of Vernonia cinerea. Khay M, Toeng P, Mahiou-Leddet V, et al. Nat. Prod. Commun. 7(10), 1259-62, (2012)

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Relevance of carcinogenicity bioassays in mice in assessing potential health risks associated with exposure to methylene chloride. Liteplo RG, Long GW, and Meek ME Hum. Exp. Toxicol. 17(2), 84-7, (1998)

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Preparation of candesartan and atorvastatin nanoparticles by solvent evaporation. Vaculikova E, Grunwaldova V, Kral V, et al. Molecules 17(11), 13221-34, (2012)

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Dichloromethane marine risk assessment with special reference to the OSPARCOM region: North Sea. De Rooij C, Thompson RS, Garny V, et al. Environ. Monit. Assess. 97(1-3), 3-22, (2004)

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Anti-tumor potential and acute toxicity of Jacaranda puberula Cham. (Bignoniacea). de-Almeida MR, Ramos-Leal IC, Ruela HS, et al. Pak. J. Pharm. Sci. 26(5), 881-92, (2013)

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In vitro and in vivo antileishmania activity of sesquiterpene lactone-rich dichloromethane fraction obtained from Tanacetum parthenium (L.) Schultz-Bip. Rabito MF, Britta EA, Pelegrini BL, et al. Exp. Parasitol. 143, 18-23, (2014)

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Induction of quinone reductase (QR) by withanolides isolated from Physalis pubescens L. (Solanaceae). Ji L, Yuan Y, Ma Z, et al. Steroids 78(9), 860-5, (2013)

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Antioxidant and anti-inflammatory activities of Pittocaulon species from México. Marín-Loaiza JC, Nieto-Camacho A, and Céspedes CL Pharm. Biol. 51(2), 260-6, (2013)

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Validated HPLC and HPTLC methods for simultaneous determination of colchicine and khellin in pharmaceutical formulations. Hadad GM, Badr JM, El-Nahriry K, et al. J. Chromatogr. Sci. 51(3), 258-65, (2013)

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Optimization extraction process of aroma components in tobacco. Luo H, Cheng H, Du W, et al. J. Chromatogr. Sci. 51(3), 250-7, (2013)

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Selective extraction of berberine and palmatine from Huangbai powder. Zhou C, Li J, Tan S, et al. Pak. J. Pharm. Sci. 26(5), 1023-5, (2013)

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Application of nano-TiO2/LDPE composite film on photocatalytic oxidation degradation of dichloromethane. Suwannahong K, Liengcharernsit W, Sanongraj W, et al. J. Environ Biol. 33(5), 955-9, (2012)

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[Admissible concentration in biological material: an index of exposure to dichloromethane]. Kupczewska-Dobecka M and Soćko R Med. Pr. 59(2), 187-95, (2008)

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Quantitating the production of biological reactive intermediates in target tissues: example, dichloromethane. Reitz RH Adv. Exp. Med. Biol. 283, 649-55, (1991)

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Merck 14,6063

Beil. 1,IV,35

Fieser 1,676 / Fieser 2,273 / Fieser 4,337 / Fieser 7,239

Aldrich MSDS 1, 621:C / Corp MSDS 1 (1), 1140:D / FT-IR 1 (1), 70:D / FT-IR 2 (1), 102:A / FT-NMR 1 (1), 105:A / IR-Spectra (2), 45:D / IR-Spectra (3), 47:E / NMR-Reference 2 (1), 72:C / RegBook 1 (1), 71:A / Sax 6, 1763 / Structure Index 1, 8:E:7 / Vapor Phase 3, 102:A

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