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27285 Sigma-Aldrich

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

Synonym: Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2

  • CAS Number 6381-92-6

  • Empirical Formula (Hill Notation) C10H14N2Na2O8 · 2H2O

  • Molecular Weight 372.24

  •  Beilstein Registry Number 3900609

  •  EC Number 205-358-3

  •  PubChem Substance ID 24856480

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Properties

Related Categories Analytical/Chromatography, Core Bioreagents, Enzyme Inhibitors, Essential Chemicals, Ethylenediaminetetraacetic acid (EDTA) and EDTA Solutions,
grade   BP (tested according to)
  Ph Eur (tested according to)
  meets USP testing specifications (tested according to)
reg. compliance   FCC (tested according to)
assay   99.0-101.0%
quality   meets analytical specification of Ph. Eur., BP, USP, FCC
impurities   residual solvents, complies
  ≤0.001% cyanide (CN)
  ≤0.001% heavy metals (as Pb)
  ≤0.1% nitrilotriacetic acid (HPLC) (HPLC)
loss   8.7-11.4% loss on drying, 200 °C, 3 h
pH   4-5 (20 °C, 5%)
mp   248 °C (dec.)(lit.)
solubility   water: soluble100 g/L at 20 °C
anion traces   chloride (Cl-): ≤100 mg/kg
  sulfate (SO42-): ≤500 mg/kg
cation traces   As: ≤1 mg/kg
  Ca:, in accordance
  Fe: ≤10 mg/kg
  Pb: ≤10 mg/kg

Description

Application

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production

Biochem/physiol Actions

Ethylenediaminetetraacetic acid disodium salt dihydrate is a widely used chelator of divalent cations like Ca+2 and inhibits metal ion-dependent proteases such as calcium-dependent cysteine proteases. EDTA also acts as a chelator of the zinc ion in the active site of metalloproteases; thus it inhibits metalloproteases that requires zinc for activity. Additionally, EDTA prevents platelet aggregation and is a preferred anticoagulant for platelet counts.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory Tract
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
AH4410000
Flash Point(F) 
>212 °F
Flash Point(C) 
>100 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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