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27600 Sigma-Aldrich

Caffeine

purum, anhydrous, ≥99.0% (HPLC)

Synonym: 1,3,7-Trimethylxanthine

  • CAS Number 58-08-2

  • Empirical Formula (Hill Notation) C8H10N4O2

  • Molecular Weight 194.19

  •  Beilstein Registry Number 17705

  •  EC Number 200-362-1

  •  MDL number MFCD00005758

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Properties

Related Categories Alkaloid, Cell Biology, Nutrition Research, Phytochemicals by Chemical Classification
grade   purum
assay   ≥99.0% (HPLC)
mp   233-238 °C
  234-236.5 °C(lit.)
Gene Information   human ... ADORA1(134), PDE4B(5142)

Description

Other Notes

Pharmacology and toxicology

Same product — same quality — now Sigma-Aldrich brand

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Price and Availability

Suggested Laboratory Gloves


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Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
EV6475000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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