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27715 Sigma-Aldrich

L-(+)-Lactic acid

80%

Synonym: (S)-2-Hydroxypropionic acid, Sarcolactic acid

  • CAS Number 79-33-4

  • Empirical Formula (Hill Notation) C3H6O3

  • Molecular Weight 90.08

  •  Beilstein Registry Number 1720251

  •  MDL number MFCD00064266

  •  PubChem Substance ID 24856738

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Properties

Related Categories Acids, Acids & Bases, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
assay   80%
ign. residue   ≤0.1% (as SO4)
solubility   water: soluble(lit.)
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤100 mg/kg
cation traces   Ca: ≤100 mg/kg
  Fe: ≤10 mg/kg

Description

Biochem/physiol Actions

Use as a substrate for the lactic acid dehydrogenase enzymes.

Packaging

1 L in poly bottle

Price and Availability

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<SC>L</SC>-(+)-Lactic acid

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<SC>L</SC>-(+)-Lactic acid

analytical standard

<SC>L</SC>-(+)-Lactic acid solution

30% in H2O (by weight)

<SC>L</SC>-(+)-Lactic acid solution

meets analytical specification of Ph. Eur., BP, 88-92% total acid basis

<SC>L-</SC>(+)-Lactic acid solution

in H2O, ≥85%

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
1
Flash Point(F) 
230 °F
Flash Point(C) 
110 °C

Documents

Certificate of Analysis

Protocols & Articles

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Peer-Reviewed Papers

References

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Swelling and hydrolytic degradation of poly (D, L-lactic acid) in aqueous solutions. Proikakis C S, et al. Polym. Degrad. Stab. 91(3), 614-19, (2006)

Recovery of L-(+)-lactic acid by anion exchange resin Amberlite IRA-400. Cao X, et al. Biochem. Eng. J. 11(2), 189-196, (2002)

The human urine metabolome. Bouatra S, Aziat F, Mandal R, et al. PLoS ONE 8(9), e73076, (2013)

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The human serum metabolome. Psychogios N, Hau DD, Peng J, et al. PLoS ONE 6(2), e16957, (2011)

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Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids. Kvitvang HF, Andreassen T, Adam T, et al. Anal. Chem. 83(7), 2705-11, (2011)

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The human cerebrospinal fluid metabolome. Wishart DS, Lewis MJ, Morrissey JA, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 871(2), 164-73, (2008)

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Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Guneral F and Bachmann C Clin. Chem. 40(6), 862-6, (1994)

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Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients. Blomqvist G, Alvarsson M, Grill V, et al. Am. J. Physiol. Endocrinol. Metab. 283(1), E20-8, (2002)

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SPE-NMR metabolite sub-profiling of urine. Jacobs DM, Spiesser L, Garnier M, et al. Anal. Bioanal. Chem 404(8), 2349-61, (2012)

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A double-blind, randomized, placebo-controlled pilot study to investigate the effects of finasteride combined with a biodegradable self-reinforced poly L-lactic acid spiral stent in patients with urinary retention caused by bladder outlet obstruction from benign prostatic hyperplasia. Isotalo T, Talja M, Hellström P, et al. BJU Int. 88(1), 30-4, (2001)

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Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Bales JR, Higham DP, Howe I, et al. Clin. Chem. 30(3), 426-32, (1984)

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Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. Shoemaker JD and Elliott WH J. Chromatogr. A 562(1-2), 125-38, (1991)

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Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis. Hoffmann G, Aramaki S, Blum-Hoffmann E, et al. Clin. Chem. 35(4), 587-95, (1989)

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Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics. Psihogios NG, Gazi IF, Elisaf MS, et al. NMR Biomed. 21(3), 195-207, (2008)

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Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Walenta S, Schroeder T, and Mueller-Klieser W Curr. Med. Chem. 11(16), 2195-204, (2004)

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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Gronwald W, Klein MS, Zeltner R, et al. Kidney Int. 79(11), 1244-53, (2011)

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Lactate as a marker of energy failure in critically ill patients: hypothesis. Valenza F, Aletti G, Fossali T, et al. Critical Care 9(6), 588-93, (2005)

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1H and (13)C NMR spectroscopic analysis of human saliva. Silwood CJ, Lynch E, Claxson AW, et al. J. Dent. Res. 81(6), 422-7, (2002)

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Physiology and pathophysiology of organic acids in cerebrospinal fluid. Hoffmann GF, Meier-Augenstein W, Stöckler S, et al. J. Inherit. Metab. Dis. 16(4), 648-69, (1993)

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High resolution 1H n.m.r. studies of vertebrate blood and plasma. Nicholson JK, Buckingham MJ, and Sadler PJ Biochem. J. 211(3), 605-15, (1983)

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Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid. Obeid R, Kasoha M, Knapp JP, et al. Clin. Chem. 53(6), 1129-36, (2007)

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Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. Subramanian A, Gupta A, Saxena S, et al. NMR Biomed. 18(4), 213-25, (2005)

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Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Zupke C, Sinskey AJ, and Stephanopoulos G Appl. Microbiol. Biotechnol. 44(1-2), 27-36, (1995)

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N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease. Jeitner TM, Bogdanov MB, Matson WR, et al. J. Neurochem. 79(5), 1109-12, (2001)

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In vivo and in vitro nuclear magnetic resonance spectroscopy as a tool for investigating hepatobiliary disease: a review of H and P MRS applications. Khan SA, Cox IJ, Hamilton G, et al. Liver Int. 25(2), 273-81, (2005)

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Urine glyceraldehyde excretion is elevated in the renal Fanconi syndrome. Jonas AJ, Lin SN, Conley SB, et al. Kidney Int. 35(1), 99-104, (1989)

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Capillary gas chromatography combined with ion trap detection for quantitative profiling of polyols in cerebrospinal fluid and plasma. Shetty HU, Holloway HW, and Rapoport SI Anal. Biochem. 224(1), 279-85, (1995)

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Urinary and plasma organic acids and amino acids in chronic fatigue syndrome. Jones MG, Cooper E, Amjad S, et al. Clin. Chim. Acta 361(1-2), 150-8, (2005)

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L-lactic acid as a mosquito (Diptera: Culicidae) repellent on human and mouse skin. Shirai Y, Kamimura K, Seki T, et al. J. Med. Entomol. 38(1), 51-4, (2001)

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Lactate and pyruvate concentrations in capillary blood from newborns. Nielsen J, Ytrebø LM, and Borud O Acta Paediatr. 83(9), 920-2, (1994)

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Plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine) and oxypurinol after rigorous exercise. Kaya M, Moriwaki Y, Ka T, et al. Metabolism 55(1), 103-7, (2006)

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Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Nakayama Y, Kinoshita A, and Tomita M Theor. Biol. Med. Model. 2, 18, (2005)

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Plasma lactate and 3-hydroxybutyrate levels in patients with acute ethanol intoxication. Fulop M, Bock J, Ben-Ezra J, et al. Am. J. Med. 80(2), 191-4, (1986)

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Merck 14,5337

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