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27890 Sigma-Aldrich

Creatine

anhydrous, ≥99.0% (NT)

Synonym: (α-Methylguanido)acetic acid, N-Amidinosarcosine

  • CAS Number 57-00-1

  • Linear Formula H2NC(=NH)N(CH3)CH2CO2H

  • Molecular Weight 131.13

  •  Beilstein Registry Number 907175

  •  EC Number 200-306-6

  •  MDL number MFCD00004282

  •  PubChem Substance ID 329753019

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Properties

Related Categories Cell Biology, Nutrition Research, Other Biochemical, Phytochemicals by Chemical Classification
InChI Key   CVSVTCORWBXHQV-UHFFFAOYSA-N
assay   ≥99.0% (NT)
impurities   ≤0.5% water
mp   ~295 °C (dec.)

Description

Other Notes

Identification of creatine as a cofactor of thiamine-diphosphate kinase

Biochem/physiol Actions

Creatine is a nitrogenous compound that acts as a high-energy reservoir for the rapid regeneration of ATP. Approximately 95% of creatine is found in skeletal muscle, primarily as phosphocreatine. Creatine can be acquired through dietary consumption or formed from L-arginine, glycine, and L-methionine in a multi-step reaction that occurs in the kidneys and liver. Creatine is then transported to muscle tissue. Creatine supplementation is used for the enhancement of sports performance, primarily by increasing muscle mass. Creatine is also being investigated as a treatment of neuromuscular diseases, where it may aid in neuroprotection and by improving the cellular bioenergetic state.

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Laboratory Gloves

All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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C0780 Creatine, anhydrous

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