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284467 Sigma-Aldrich

2-Methoxyethanol

anhydrous, 99.8%

Synonym: Ethylene glycol monomethyl ether, Methyl glycol

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Properties

Related Categories Anhydrous Solvents, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents,
grade   anhydrous
vapor density   2.62 (vs air)
vapor pressure   6.17 mmHg ( 20 °C)
assay   99.8%
autoignition temp.   548 °F
expl. lim.   24.5 %
impurities   <0.005% water
evapn. residue   <0.0005%
refractive index   n20/D 1.402(lit.)
bp   124-125 °C(lit.)
mp   −85 °C(lit.)
density   0.965 g/mL at 25 °C(lit.)

Description

Packaging

1, 2 L in Sure/Seal™

100 mL in Sure/Seal™

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45
RIDADR 
UN 1188 3 / PGIII
WGK Germany 
2
RTECS 
KL5775000
Flash Point(F) 
104 °F
Flash Point(C) 
40 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

A transferable force field to predict phase equilibria and surface tension of ethers and glycol ethers. Ferrando N, Lachet V, Pérez-Pellitero J, et al. J. Phys. Chem. B 115(36), 10654-64, (2011)

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Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites. Louisse J, Bai Y, Verwei M, et al. Toxicol. Appl. Pharmacol. 245(2), 236-43, (2010)

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Effects of male reproductive toxicants on gene expression in rat testes. Fukushima T, Yamamoto T, Kikkawa R, et al. J. Toxicol. Sci. 30(3), 195-206, (2005)

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Removal of toxic uranium from synthetic nuclear power reactor effluents using uranyl ion imprinted polymer particles. Preetha CR, Gladis JM, Rao TP, et al. Environ. Sci. Technol. 40(9), 3070-4, (2006)

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A new biocompatible nanoparticle delivery system for the release of fibrinolytic drugs. Piras AM, Chiellini F, Fiumi C, et al. Int. J. Pharm. 357(1-2), 260-71, (2008)

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Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family. Takei M, Ando Y, Saitoh W, et al. Toxicol. Sci. 118(2), 643-52, (2010)

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The mechanism of ethylene glycol ether reproductive and developmental toxicity and evidence for adverse effects in humans. Welsch F Toxicol. Lett. 156(1), 13-28, (2005)

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Evaluation of the protective effectiveness of gloves from occupational exposure to 2-methoxyethanol using the biomarkers of 2-methoxyacetic acid levels in the urine and plasma. Chang HY, Lin CC, Shih TS, et al. Occup. Environ. Med. 61(8), 697-702, (2004)

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Evaporation and discharge dynamics of highly charged multicomponent droplets generated by electrospray ionization. Grimm RL and Beauchamp JL J. Phys. Chem. A 114(3), 1411-9, (2010)

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Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats. Starek A, Szymczak W, and Zapor L Arch. Toxicol. 82(2), 125-36, (2008)

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Dead Sea Minerals loaded polymeric nanoparticles. Dessy A, Kubowicz S, Alderighi M, et al. Colloids Surf. B Biointerfaces 87(2), 236-42, (2011)

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Hemoglobin loaded polymeric nanoparticles: preparation and characterizations. Dessy A, Piras AM, Schirò G, et al. Eur. J. Pharm. Sci. 43(1-2), 57-64, (2011)

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Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media. Nakano S, Wu L, Oka H, et al. Mol. Biosyst. 4(6), 579-88, (2008)

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Evaluation of cryoprotectant and cooling rate for sperm cryopreservation in the euryhaline fish medaka Oryzias latipes. Yang H, Norris M, Winn R, et al. Cryobiology 61(2), 211-9, (2010)

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Differential stimulation pathways of progesterone secretion from newly formed corpora lutea in rats treated with ethylene glycol monomethyl ether, sulpiride, or atrazine. Taketa Y, Yoshida M, Inoue K, et al. Toxicol. Sci. 121(2), 267-78, (2011)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis. Scofield EH, Henderson WM, Funk AB, et al. Reprod. Toxicol. 22(4), 718-24, (2006)

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Hepatic effects in workers exposed to 2-methoxy ethanol. Loh CH, Shih TS, Hsieh AT, et al. J. Occup. Environ. Med. 46(7), 707-13, (2004)

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Chemically induced supernumerary lumbar ribs in CD-1 mice: size distribution and dose response. Rogers JM, Setzer RW, Branch S, et al. Birth Defects Res. B Dev. Reprod. Toxicol. 71(1), 17-25, (2004)

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Effects of ethylene glycol ethers on cell viability in the human neuroblastoma SH-SY5Y cell line. Regulska M, Pomierny B, Basta-Kaim A, et al. Pharmacol. Rep. 62(6), 1243-9, (2010)

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Collaborative work on evaluation of ovarian toxicity. 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats. Dodo T, Taketa Y, Sugiyama M, et al. J. Toxicol. Sci. 34 Suppl 1, SP121-8, (2009)

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Histopathological characteristics of luteal hypertrophy induced by ethylene glycol monomethyl ether with a comparison to normal luteal morphology in rats. Taketa Y, Inomata A, Hosokawa S, et al. Toxicol. Pathol. 39(2), 372-80, (2011)

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Reduction in telomere length in individuals exposed in utero to glycol ether. El-Zein R, Albrecht T, Knutson E, et al. Arch. Environ. Occup. Health 62(3), 161-3, (2007)

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The relation between cryoprotective and physicochemical properties of oxyethylated methyl cellosolve-based media. Nikolenko AV, Chekanova VV, Schetinsky MI, et al. Cryo. Letters 34(5), 527-34, (2013)

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[Ethylene glycol alkyl ethers--the substances noxious to health]. Starek A and Szabla J Med. Pr. 59(2), 179-85, (2008)

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Metabolomics and mechanisms: sometimes the fisher catches a big fish. Cantor GH Toxicol. Sci. 118(2), 321-3, (2010)

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Testicular gene expression profiling following 2-methoxyethanol and 2-ethoxyethanol exposure in male rats reveals abnormal expression of the actin binding protein cortactin in degenerating spermatocytes. Tonkin EG, Cooper M, Lollini LO, et al. Toxicol. Lett. 190(2), 193-201, (2009)

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Merck 14,6038

Beil. 1,IV,2375

Aldrich MSDS 1, 1182:B / Corp MSDS 1 (2), 2249:B / FT-IR 1 (1), 222:D / FT-IR 2 (1), 323:B / FT-NMR 1 (1), 336:C / IR-Spectra (3), 133:C / IR-Spectra (2), 121:G / RegBook 1 (1), 223:A / Sax 6, 1345 / Sigma FT-IR 1 (2), 553:C / Structure Index 1, 30:B:9 / Vapor Phase 3, 293:A

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