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296090 Sigma-Aldrich

Hexane

anhydrous, 95%

Synonym: n-Hexane

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Properties

Related Categories Anhydrous Solvents, Hexane, Solvent by Type, Solvent Bottles, Solvent Packaging Options,
grade   anhydrous
vapor density   ~3 (vs air)
vapor pressure   256 mmHg ( 37.7 °C)
  5.2 psi ( 37.7 °C)
  ~132 mmHg ( 20 °C)
assay   95%
autoignition temp.   453 °F
expl. lim.   7.7 %
impurities   <0.001% water
  <0.005% water (100 mL pkg)
evapn. residue   <0.0003%
refractive index   n20/D 1.375(lit.)
bp   69 °C(lit.)
mp   −95 °C(lit.)
density   0.659 g/mL at 25 °C(lit.)

Description

Packaging

1, 6×1, 2 L in Sure/Seal™

100 mL in Sure/Seal™

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.





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Safety & Documentation

Safety Information

Signal word 
Danger
Precautionary statements 
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
9-16-29-33-36/37-61-62
RIDADR 
UN 1208 3 / PGII
WGK Germany 
2
RTECS 
MN9275000
Flash Point(F) 
-13 °F
Flash Point(C) 
-25 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in n-Hexane Using Karl Fischer Titration

Water determination in hydrocarbons is relatively straightforward. Lower hydrocarbons dissolve in methanol, however, even if the dissolution is incomplete, the water is rapidly extracted and complete...
Keywords: Titrations

Peer-Reviewed Papers

References

Set your institution to view full text papers.

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A membrane bioreactor for the simultaneous treatment of acetone, toluene, limonene and hexane at trace level concentrations. Lebrero R, Volckaert D, Pérez R, et al. Water Res. 47(7), 2199-212, (2013)

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Direct lipid extraction from wet Chlamydomonas reinhardtii biomass using osmotic shock. Yoo G, Park WK, Kim CW, et al. Bioresour. Technol. 123, 717-22, (2012)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Mechanisms and models of neurotoxicity of n-hexane and related solvents. Tähti H, Engelke M, and Vaalavirta L Arch. Toxicol. Suppl. 19, 337-45, (1997)

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n-hexane polyneuropathy in Japan: a review of n-hexane poisoning and its preventive measures. Takeuchi Y Environ. Res. 62(1), 76-80, (1993)

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[Toxicity and dose-response (effect) relationship of n-hexane (author's transl)]. Takeuchi Y, Hisanaga N, Ono Y, et al. Sangyo. Igaku. 22(6), 470-87, (1980)

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[Toxicity, biotransformation and biological effect of n-hexane (review of the literature)]. Tikhonova GP Gig. Tr. Prof. Zabol. (3), 38-40, (1984)

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n-Hexane. Rev. Environ. Contam. Toxicol. 106, 155-64, (1988)

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Estimating stepwise debromination pathways of polybrominated diphenyl ethers with an analogue Markov Chain Monte Carlo algorithm. Zou Y, Christensen ER, Zheng W, et al. Chemosphere 114, 187-94, (2014)

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[Identification of components of the milky juice of Lactarius pergamenus (Fr.)Fr fungi by gas-liquid chromatography/mass spectrometry]. Tsyvins'ka MV, Panchak LV, Stoĭka RS, et al. Ukr. Biokhim. Zh. 85(5), 170-6, (2013)

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Alternative biomarkers of n-hexane exposure: characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-hexanedione. Torres ME, Gonçalves LL, Bronze MR, et al. Toxicol. Lett. 224(1), 54-63, (2014)

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Aroma profiles and preferences of Jasminum sambac L. flowers grown in Thailand. Kanlayavattanakul M, Kitsiripaisarn S, and Lourith N J. Cosmet. Sci. 64(6), 483-93, (2013)

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N-hexane alters the maturation of oocytes and induces apoptosis in mice. Liu J, Huang L, Sun Y, et al. Biomed. Environ. Sci. 26(9), 735-41, (2013)

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Distribution of pesticides in n-hexane/water and n-hexane/acetonitrile systems and estimation of possibilities of their extraction isolation and preconcentration from various matrices. Zayats MF, Leschev SM, Petrashkevich NV, et al. Anal. Chim. Acta 774, 33-43, (2013)

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Electronic deactivation of guanosine in extended hydrogen-bonded self-assemblies. Röttger K, Schwalb NK, and Temps F J. Phys. Chem. A 117(12), 2469-78, (2013)

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Adsorption and dilational rheology of mixed β-casein/DoTAB layers formed by sequential and simultaneous adsorption at the water/hexane interface. Dan A, Wüstneck R, Krägel J, et al. Langmuir 29(7), 2233-41, (2013)

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[The Effect biomarkers of n-hexane peripheral neurotoxicity]. Zhu DX, Lao XQ, and Yu DX Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 30(10), 789-91, (2012)

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Antiproliferative activity of flower hexane extract obtained from Mentha spicata associated with Mentha rotundifolia against the MCF7, KB, and NIH/3T3 cell lines. Nedel F, Begnini K, Carvalho PH, et al. J. Med. Food 15(11), 955-8, (2012)

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Enhanced H2 uptake in solvents confined in mesoporous metal-organic framework. Clauzier S, Ho LN, Pera-Titus M, et al. J. Am. Chem. Soc. 134(42), 17369-71, (2012)

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Characterization and evolution of exposure to volatile organic compounds in the Spanish shoemaking industry over a 5-year period. Estevan C, Ferri F, Sogorb MA, et al. J. Occup. Environ. Hyg. 9(11), 653-62, (2012)

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The effect of n-hexane on the gonad toxicity of female mice. Liu J, Huang HL, Pang F, et al. Biomed. Environ. Sci. 25(2), 189-96, (2012)

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[Peripheral neuropathy by chronic deliberate inhalation of benzine (n-hexane). A case report and review of the literature]. Malbergier A Rev. Paul. Med. 108(3), 142-4, (1990)

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Polyneuropathy induced by n-hexane intoxication in Taiwan. Huang CC Acta Neurol. Taiwan. 17(1), 3-10, (2008)

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Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione. Couri D and Milks M Annu. Rev. Pharmacol. Toxicol. 22, 145-66, (1982)

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Analysis of anabolic androgenic steroids in urine by full-capillary sample injection combined with a sweeping CE stacking method. Wang CC, Cheng SF, Cheng HL, et al. Anal. Bioanal. Chem 405(6), 1969-76, (2013)

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Influence of drying and cooking process on the phytochemical content, antioxidant and hypoglycaemic properties of two bell Capsicum annum L. cultivars. Loizzo MR, Pugliese A, Bonesi M, et al. Food Chem. Toxicol. 53, 392-401, (2013)

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Selective pressurised liquid extraction of halogenated pesticides and polychlorinated biphenyls from pine needles. Lavin KS and Hageman KJ J. Chromatogr. A 1258, 30-6, (2012)

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Development of a one-step microwave-assisted extraction method for simultaneous determination of organophosphorus pesticides and fungicides in soils by gas chromatography-mass spectrometry. Merdassa Y, Liu JF, and Megersa N Talanta 114, 227-34, (2013)

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QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES. A A Toropov et al Eur. J. Med. Chem. 43, 714-40, (2008)

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Effects of covered solid sorbent tube sample holders on organic vapor measurements. Marpoe BS, Groves WA, Lee EG, et al. J. Occup. Environ. Hyg. 9(10), 572-9, (2012)

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Limitations of occupational air contaminant standards, as exemplified by the neurotoxin N-hexane. Lanska DJ J. Public Health Policy 20(4), 441-58, (1999)

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Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. Jung DM, Yoon SH, and Jung MY J. Food Sci. 77(12), C1249-55, (2012)

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Occupational ototoxicity of n-hexane. Vyskocil A, Leroux T, Truchon G, et al. Hum. Exp. Toxicol. 27(6), 471-6, (2008)

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Chemometric profile of root extracts of Rhodiola imbricata Edgew. with hyphenated gas chromatography mass spectrometric technique. Tayade AB, Dhar P, Kumar J, et al. PLoS ONE 8(1), e52797, (2013)

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Novel skeleton transformation reaction of α-pyrone derivatives to spirobicyclo[3.1.0]hexane derivatives using dimethylsulfoxonium methylide. Miura T, Yadav ND, Iwasaki H, et al. Org. Lett. 14(23), 6048-51, (2012)

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n-Hexane neurotoxicity: a mechanism involving pyrrole adduct formation in axonal cytoskeletal protein. DeCaprio AP Neurotoxicology 8(1), 199-210, (1987)

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Ultrasound assisted dialysis of semi-permeable membrane devices for the simultaneous analysis of a wide number of persistent organic pollutants. Bustamante J, Navarro P, Arana G, et al. Talanta 114, 32-7, (2013)

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Structure and compatibility of a magnesium electrolyte with a sulphur cathode. Kim HS, Arthur TS, Allred GD, et al. Nat. Commun. 2, 427, (2011)

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N-hexane and its toxicologic effects: a review. Jørgensen NK and Cohr KH Scand. J. Work. Environ. Health 7(3), 157-68, (1981)

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Involvement of the essential metal transporter Zip14 in hepatic Cd accumulation during inflammation. Min KS, Takano M, Amako K, et al. Toxicol. Lett. 218(1), 91-6, (2013)

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In vitro antimicrobial activity on clinical microbial strains and antioxidant properties of Artemisia parviflora. Ahameethunisa AR and Hopper W Ann. Clin. Microbiol. Antimicrob. 11, 30, (2012)

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Dispersive liquid-liquid microextraction of propranolol enantiomers from human plasma based on the solidification of a floating organic droplet. Farhadi K, Hatami M, Forough M, et al. Bioanalysis 5(6), 701-10, (2013)

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Elevated CO2 influences nematode-induced defense responses of tomato genotypes differing in the JA pathway. Yucheng Sun et al PLoS ONE 6, e19751, (2011)

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2,5-hexanedione altered the degradation of low-molecular-weight neurofilament in rat nerve tissues. Song F, Zhang Q, Kou R, et al. Food Chem. Toxicol. 50(12), 4277-84, (2012)

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Key role of organic carbon in the sunlight-enhanced atmospheric aging of soot by O2. Han C, Liu Y, Ma J, et al. Proc. Natl. Acad. Sci. U. S. A. 109(52), 21250-5, (2012)

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Immunomodulatory effects of hexane insoluble fraction of Ficus septica Burm. F. in doxorubicin-treated rats. Nugroho AE, Hermawan A, Nastiti K, et al. Asian Pac. J. Cancer Prev. 13(11), 5785-90, (2012)

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Study of the potential oxidative stress induced by six solvents in the rat brain. Chalansonnet M, Carabin N, Boucard S, et al. Neurotoxicology 35, 71-83, (2013)

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Toxic neurofilamentous axonopathies -- accumulation of neurofilaments and axonal degeneration. Llorens J J. Intern. Med. 273(5), 478-89, (2013)

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Phytochemical and in vitro total antioxidant capacity analyses of peel extracts of different cultivars of Cucumis melo and Citrullus lanatus. Asghar MN, Shahzad MT, Nadeem I, et al. Pharm. Biol. 51(2), 226-32, (2013)

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An ultrasonic assisted extraction procedure to free fatty acids from the liver samples of mice. Liu L, Na L, Niu Y, et al. J. Chromatogr. Sci. 51(4), 376-82, (2013)

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Inhibitory and bactericidal activity of selected South African honeys and their solvent extracts against clinical isolates of Helicobacter pylori. Manyi-Loh CE, Clarke AM, Green E, et al. Pak. J. Pharm. Sci. 26(5), 897-906, (2013)

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Inhibitory effects of Olea ferruginea crude leaves extract against some bacterial and fungal pathogen. Amin A, Khan MA, Shah S, et al. Pak. J. Pharm. Sci. 26(2), 251-4, (2013)

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Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots. Siripong P, Rassamee K, Piyaviriyakul S, et al. Asian Pac. J. Cancer Prev. 13(7), 3519-28, (2012)

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Solvent systems with n-hexane and/or cyclohexane in countercurrent chromatography--Physico-chemical parameters and their impact on the separation of alkyl hydroxybenzoates. Englert M and Vetter W J. Chromatogr. A 1342, 54-62, (2014)

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Analysis of petroleum contaminated soils by spectral modeling and pure response profile recovery of n-hexane. Chakraborty S, Weindorf DC, Li B, et al. Environ. Pollut. 190, 10-8, (2014)

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Merck 14,4694

Beil. 1,IV,338

Aldrich MSDS 1, 1027:C / Corp MSDS 1 (1), 1854:D / FT-IR 2 (1), 3:B / FT-IR 1 (1), 1:B / FT-NMR 1 (1), 1:B / IR-Spectra (3), 3:B / IR-Spectra (2), 3:B / NMR-Reference 2 (1), 9:B / RegBook 1 (1), 3:F / Sax 6, 1523 / Sigma FT-IR 1 (2), 609:D / Structure Index 1, 1:A:2 / Vapor Phase 3, 2:B

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