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29875 Sigma-Aldrich

Cyclophosphamide monohydrate

Synonym: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan

  • CAS Number 6055-19-2

  • Empirical Formula (Hill Notation) C7H15Cl2N2O2P · H2O

  • Molecular Weight 279.10

  •  Beilstein Registry Number 4678992

  •  EC Number 200-015-4

  •  MDL number MFCD00149395

  •  PubChem Substance ID 329753395

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Properties

InChI Key   PWOQRKCAHTVFLB-UHFFFAOYSA-N
mp   49-51 °C(lit.)
solubility   H2O: soluble0.1 g/mL, clear, colorless
storage temp.   2-8°C

Description

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3464 6.1 / PGIII
WGK Germany 
3
RTECS 
RP6157750
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles

Articles

Autophagy in Cancer Promotes Therapeutic Resistance

Autophagy is a highly regulated process by which long-lived proteins, organelles, and protein aggregates are captured within autophagosomes, which are then fused with lysosomes for degradation.1 Auto...
Keywords: Apoptosis, Autophagy, Cancer, Degradations, Metabolites, transformation

Peer-Reviewed Papers
15

References

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