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29875 Sigma-Aldrich

Cyclophosphamide monohydrate

Synonym: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan

  • CAS Number 6055-19-2

  • Empirical Formula (Hill Notation) C7H15Cl2N2O2P · H2O

  • Molecular Weight 279.10

  •  Beilstein Registry Number 4678992

  •  EC Number 200-015-4

  •  MDL number MFCD00149395

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Properties

InChI Key   PWOQRKCAHTVFLB-UHFFFAOYSA-N
mp   49-51 °C(lit.)
solubility   H2O: soluble0.1 g/mL, clear, colorless
storage temp.   2-8°C

Description

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3464 6.1 / PGIII
WGK Germany 
3
RTECS 
RP6157750
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles

Articles

Autophagy in Cancer Promotes Therapeutic Resistance

Autophagy is a highly regulated process by which long-lived proteins, organelles, and protein aggregates are captured within autophagosomes, which are then fused with lysosomes for degradation.1 Auto...
Keywords: Apoptosis, Autophagy, Cancer, Degradations, Metabolites, transformation

Peer-Reviewed Papers
15

References

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