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31375 Sigma-Aldrich

Dexamethasone

tested according to Ph.Eur.

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Dexamethasonum, Prednisolone F

  • CAS Number 50-02-2

  • Empirical Formula (Hill Notation) C22H29FO5

  • Molecular Weight 392.46

  •  Beilstein Registry Number 2066651

  •  EC Number 200-003-9

  •  MDL number MFCD00064136

  •  PubChem Substance ID 329753755

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Properties

Related Categories Analytical/Chromatography, Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z,
InChI Key   UREBDLICKHMUKA-CXSFZGCWSA-N
assay   99.6%
form   solid
pharmacopeia   testing conforms to Pharmacopeia
mp   262-264 °C(lit.)
solubility   water: soluble10mg/100 ml at 25 °C
  acetone: very slightly soluble
  alcohol: very slightly soluble
  chloroform: slightly soluble
  diethyl ether: very slightly soluble
  dioxane: very slightly soluble
  methanol: very slightly soluble
Gene Information   human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Description

Application

Dexamethasone has been used as a DMEM medium supplement utilized in osteogenesis. It has also been used as an alpha-MEM medium supplement to initiate adipogenic differentiation. Additionally, it has also been used to study apoptosis, cell signaling pathways and gene expression.

Biochem/physiol Actions

Dexamethasone is a glucocorticoid anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Additionally, dexamethasone inhibits the induction of nitric oxide synthase. It induces apoptosis by initiating the initial cleavage of DNA into high molecular weight fragments.

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
TU3980000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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