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320102 Sigma-Aldrich

Acetic anhydride

ReagentPlus®, ≥99%

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Properties

grade   ReagentPlus®
vapor density   3.5 (vs air)
vapor pressure   10 mmHg ( 36 °C)
  4 mmHg ( 20 °C)
assay   ≥99%
autoignition temp.   629 °F
expl. lim.   10.3 %
refractive index   n20/D 1.390(lit.)
bp   138-140 °C(lit.)
mp   −73 °C(lit.)
solubility   water: slightly soluble
density   1.08 g/mL(lit.)

Description

Packaging

1 L in glass bottle

100, 4×100, 500 mL in glass bottle

Application

Acetic anhydride was used in the following studies:
• Lipozyme TL IM (commercial immobilized lipase from Thermomyces lanuginosus) catalyzed acetylation of essential clove oil.
• As acetyl donor to investigate the lipase catalyzed acetylation of nanofibrillated cellulose (NFC).
• Synthesis of N-substituted pyrazolines.
• Acetylation of Barnyardgrass (Echinochloa crus-galli) starch.

General description

Acetic anhydride participates in the Friedel-Craft′s intramolecular cyclization reaction of cyclopropyl ketones to afford the tetralones. It has been reported to promote the Knoevenagel condensation of various aldehydes and activated methylene compounds.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1715 3(8) / PGII
WGK Germany 
1
RTECS 
AK1925000
Flash Point(F) 
120.2 °F
Flash Point(C) 
49 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Friedel–Crafts Acylation

The Friedel–Crafts acylation is the reaction of an arene with acyl chlorides or anhydrides using a strong Lewis acid catalyst. This reaction proceeds via electrophilic aromatic substitution to form m...
Keywords: Acylations, Catalysis, Electrophilic aromatic substitution, Microwave synthesis, Substitutions

Peer-Reviewed Papers
15

References

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