Sulfanilamide

Papers

Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. Isao Nishimori et al J. Med. Chem. 48, 7860-6, (2005)

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Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Alessio Innocenti et al Bioorg. Med. Chem. Lett. 15, 1149-54, (2005)

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Synthesis and in vitro study of novel Mannich bases as antibacterial agents. Sheela Joshi et al Bioorg. Med. Chem. Lett. 15, 221-6, (2005)

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Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Luca Puccetti et al Bioorg. Med. Chem. Lett. 15, 2359-64, (2005)

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Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors. Jean-Yves Winum et al Bioorg. Med. Chem. Lett. 15, 3302-6, (2005)

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Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. Hasan Turkmen et al Bioorg. Med. Chem. Lett. 15, 367-72, (2005)

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Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Francesco Mincione et al Bioorg. Med. Chem. Lett. 15, 3821-7, (2005)

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Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Isao Nishimori et al Bioorg. Med. Chem. Lett. 15, 3828-33, (2005)

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QSAR study on the antibacterial activity of some sulfa drugs: building blockers of Mannich bases. Dheeraj Mandloi et al Bioorg. Med. Chem. Lett. 15, 405-11, (2005)

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Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Ozen Ozensoy et al Bioorg. Med. Chem. Lett. 15, 4862-6, (2005)

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Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters. Padmakar V Khadikar et al Bioorg. Med. Chem. Lett. 15, 931-6, (2005)

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Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Daniela Vullo et al Bioorg. Med. Chem. Lett. 15, 971-6, (2005)

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Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. Isao Nishimori et al J. Med. Chem. 49, 2117-26, (2006)

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QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach. Vijay K Agrawal et al Bioorg. Med. Chem. Lett. 16, 2044-51, (2006)

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Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori. Isao Nishimori et al Bioorg. Med. Chem. Lett. 16, 2182-8, (2006)

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Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9. Charles W Locuson et al J. Med. Chem. 50, 1158-65, (2007)

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Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. Isao Nishimori et al J. Med. Chem. 50, 381-8, (2007)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Anti-mycobacterial activity of a bis-sulfonamide. Brendan L Wilkinson et al Bioorg. Med. Chem. Lett. 17, 1355-7, (2007)

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Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors. Isao Nishimori et al Bioorg. Med. Chem. Lett. 17, 3585-94, (2007)

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Synthesis, structure analysis, and antibacterial activity of some novel 10-substituted 2-(4-piperidyl/phenyl)-5,5-dioxo[1,2,4]triazolo[1,5-b][1,2,4]benzothiadiazine derivatives. Ahmed Kamal et al Bioorg. Med. Chem. Lett. 17, 5400-5, (2007)

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Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide. Sheela Joshi et al Bioorg. Med. Chem. Lett. 17, 645-8, (2007)

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Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents. Ahmed Kamal et al Bioorg. Med. Chem. 15, 1004-13, (2007)

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Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Isao Nishimori et al Bioorg. Med. Chem. 15, 7229-36, (2007)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII. Marouan Rami et al Bioorg. Med. Chem. Lett. 18, 836-41, (2008)

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Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate. Tomoko Minakuchi et al J. Med. Chem. 52, 2226-32, (2009)

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Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis. Isao Nishimori et al J. Med. Chem. 52, 3116-20, (2009)

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Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. Mika Hilvo et al J. Med. Chem. 52, 646-54, (2009)

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Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. Fabrizio Carta et al Bioorg. Med. Chem. Lett. 19, 6649-54, (2009)

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Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates. Semra Isik et al Bioorg. Med. Chem. 17, 1158-63, (2009)

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Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides. Alessio Innocenti et al Bioorg. Med. Chem. 17, 4503-9, (2009)

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Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Anthony Bertucci et al Bioorg. Med. Chem. 17, 5054-8, (2009)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis. Pascale Joseph et al J. Med. Chem. 53, 2277-85, (2010)

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The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. Claudia Temperini et al J. Med. Chem. 53, 850-4, (2010)

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Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides. Daniela Vullo et al Bioorg. Med. Chem. Lett. 20, 2178-82, (2010)

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3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors. Kalyan K Sethi et al Bioorg. Med. Chem. Lett. 20, 3089-93, (2010)

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Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library. Rohan A Davis et al Bioorg. Med. Chem. 18, 14-8, (2010)

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Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Feray Kockar et al Bioorg. Med. Chem. 18, 5498-503, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases. Rohan A Davis et al J. Med. Chem. 54, 1682-92, (2011)

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Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides. Pacchiano, F., et al. Bioorg. Med. Chem. Lett. 21, 102-105, (2011)

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Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II). Yohei Munei et al Bioorg. Med. Chem. Lett. 21, 141-4, (2011)

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Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII. Marouan Rami et al Bioorg. Med. Chem. Lett. 21, 2975-9, (2011)

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Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II. Edward E Knaus et al Bioorg. Med. Chem. Lett. 21, 5892-6, (2011)

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Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. Anthony Bertucci et al Bioorg. Med. Chem. Lett. 21, 710-4, (2011)

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A new ?-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth. Pascale Joseph et al Bioorg. Med. Chem. 19, 1172-8, (2011)

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Inhibition studies of the ?-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates. Isao Nishimori et al Bioorg. Med. Chem. 19, 5023-30, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Cloning, characterization and sulfonamide inhibition studies of an ?-carbonic anhydrase from the living fossil sponge Astrosclera willeyana. Anna Ohradanova et al Bioorg. Med. Chem. 20, 1403-10, (2012)

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Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: Influences on the catalytic activity and affinity for inhibitors. Sumeyye Turkoglu et al Bioorg. Med. Chem. 20, 2208-13, (2012)

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Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases. Janina Moeker et al Bioorg. Med. Chem. 20, 2392-404, (2012)

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Merck 14,8925

Beil. 14,IV,2658

FT-IR 1 (2), 532:B / FT-IR 2 (2), 3294:B / FT-NMR 1 (2), 1636:B / IR-Spectra (2), 1024:H / IR-Spectra (3), 1176:D / NMR-Reference 2 (2), 851:D / RegBook 1 (2), 2243:A / Sax 6, 2480 / Sigma FT-IR 1 (1), 716:C / Structure Index 1, 352:D:2