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34854 Sigma-Aldrich

Chloroform

CHROMASOLV®, for HPLC, ≥99.8%, amylene stabilized

Synonym: Methylidyne trichloride, Trichloromethane

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Properties

Related Categories Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, CHROMASOLV for HPLC, Chloroform,
grade   CHROMASOLV®
  for HPLC
vapor density   4.1 (vs air)
vapor pressure   160 mmHg ( 20 °C)
assay   ≥99.8%
quality   amylene stabilized
impurities   Free acid, in accordance
  acetone, aldehyde, in accordance (nessler test)
  free chlorine (Cl), in accordance
  ≤0.0005% non-volatile matter
  ≤0.001% free acid (as HCl)
  <0.01% water (Karl Fischer)
evapn. residue   ≤0.0005%
color   APHA: ≤10
transmittance   250 nm, ≥50%
  260 nm, ≥85%
  280 nm, ≥99%
refractive index   n20/D 1.445(lit.)
bp   60.5-61.5 °C(lit.)
mp   −63 °C(lit.)
density   1.48 g/mL at 25 °C
  1.492 g/mL at 25 °C(lit.)
anion traces   chloride (Cl-): in accordance
cation traces   Pb: ≤0.05 mg/kg
absorption   absorption/ in accordance
λ   H2O reference
UV absorption   λ: 250 nm Amax: ≤1.00
  λ: 260 nm Amax: ≤0.30
  λ: 280 nm Amax: ≤0.005
suitability   passes test for reaction against H2SO4
  passes test for suitability of determ. w. dithizone

Description

Packaging

1, 4×4 L in glass bottle

100 mL in glass bottle

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CHROMASOLV is a registered trademark of Sigma-Aldrich Laborchemikalien GmbH

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ACS spectrophotometric grade, ≥99.8%, contains amylenes as stabilizer

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for HPLC, ≥99.8%

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Precautionary statements 
RIDADR 
UN 1888 6.1 / PGIII
WGK Germany 
3
RTECS 
FS9100000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Identification of Dehalobacter reductive dehalogenases that catalyse dechlorination of chloroform, 1,1,1-trichloroethane and 1,1-dichloroethane. Tang S and Edwards EA Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1616), 20120318, (2013)

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Patterns of chloroform metabolism. Charlesworth FA Food Cosmet. Toxicol. 14(1), 59-60, (1976)

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[Hygienic importance of the transformation of chemical substances with the formation of chloroform in the process of drinking water decontamination]. Sergeev EP, Elakhovskaia NP, and Skvortsov AF Gig. Sanit. (6), 56-9, (1981)

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"HANSGEN" amber bottle for the Wachter chloroform dropper. Anesthesiology 120(5), 1191, (2014)

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The Wachter chloroform dropper. Anesthesiology 120(5), 1117, (2014)

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DNA isolation from mammalian samples. Liu X and Harada S Curr. Protoc. Mol. Biol. Chapter 2, Unit2.14, (2013)

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Effect of trichloromethane on the bond strengths between acrylic teeth and different heat-cured denture bases: a comparative study. Bharat JS, Naidu DL, Reddy MV, et al. J. Contemp. Dent. Pract. 13(6), 850-5, (2012)

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G.B. Snow's inhaler or chloroform mixer. Bause GS Anesthesiology 118(2), 250, (2013)

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Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotides. Sirsi, SR J. Nanobiotechnology 7, 1, (2009)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Determination of volatile components of green, black, oolong and white tea by optimized ultrasound-assisted extraction-dispersive liquid-liquid microextraction coupled with gas chromatography. Sereshti H, Samadi S, and Jalali-Heravi M J. Chromatogr. A 1280, 1-8, (2013)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Chloroform in the environment: occurrence, sources, sinks and effects. McCulloch A Chemosphere 50(10), 1291-308, (2003)

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Microbial degradation of chloroform. Cappelletti M, Frascari D, Zannoni D, et al. Appl. Microbiol. Biotechnol. 96(6), 1395-409, (2012)

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Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications. Billaud M PLoS ONE 4(7), e6432, (2009)

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Mechanisms and transition states of 1,3-dipolar cycloadditions of phenyl azide with enamines: a computational analysis. Lopez SA, Munk ME, and Houk KN J. Org. Chem. 78(4), 1576-82, (2013)

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Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. Ireland DD, Stohlman SA, Hinton DR, et al. J. Virol. 82(1), 300-10, (2008)

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A review of the mutagenicity of chloroform. Rosenthal SL Environ. Mol. Mutagen. 10(2), 211-26, (1987)

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Trihalomethanes and maximum contaminant levels: the significance of inhalation and dermal exposures to chloroform in household water. Maxwell NI, Burmaster DE, and Ozonoff D Regul Toxicol Pharmacol 14(3), 297-312, (1991)

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Risk assessment case study--chloroform and related substances. Fawell J Food Chem. Toxicol. 38(1 Suppl), S91-5, (2000)

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Investigations on diffusion limitations of biocatalyzed reactions in amphiphilic polymer conetworks in organic solvents. Schoenfeld I, Dech S, Ryabenky B, et al. Biotechnol. Bioeng. 110(9), 2333-42, (2013)

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Chloroform mode of action: implications for cancer risk assessment. Golden RJ, Holm SE, Robinson DE, et al. Regul Toxicol Pharmacol 26(2), 142-55, (1997)

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Raman and ROA spectra of (-)- and (+)-2-Br-hexahelicene: experimental and DFT studies of a π-conjugated chiral system. Johannessen C, Blanch EW, Villani C, et al. J. Phys. Chem. B 117(7), 2221-30, (2013)

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Chloroform: exposure estimation, hazard characterization, and exposure-response analysis. Meek ME, Beauchamp R, Long G, et al. J. Toxicol. Environ. Health. B. Crit. Rev. 5(3), 283-334, (2002)

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The role of regenerative cell proliferation in chloroform-induced cancer. Butterworth BE, Templin MV, Borghoff SJ, et al. Toxicol. Lett. 82-83, 23-6, (1995)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element. Legiewicz M, Badorrek CS, Turner KB, et al. Proc. Natl. Acad. Sci. U. S. A. 105(38), 14365-70, (2008)

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Chemometric profile of root extracts of Rhodiola imbricata Edgew. with hyphenated gas chromatography mass spectrometric technique. Tayade AB, Dhar P, Kumar J, et al. PLoS ONE 8(1), e52797, (2013)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Configuration of PKCα-C2 domain bound to mixed SOPC/SOPS lipid monolayers. Chiu-Hao Chen et al Biophys. J. 97, 2794-802, (2009)

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Photoluminescent toroids formed by temperature-driven self-assembly of rhodamine B end-capped poly(N-isopropylacrylamide). Hsu CY, Chang SC, Hsu KY, et al. Macromol. Rapid Commun. 34(8), 689-94, (2013)

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Critical chromatography in ternary solvents. Mlynek M and Radke W J. Chromatogr. A 1284, 112-7, (2013)

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Peptide adsorption to lipid bilayers: slow processes revealed by linear dichroism spectroscopy. Ennaceur SM Biophys. J. 96(4), 1399-407, (2009)

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Detection of human insulin-like growth factor-1 in deer antler velvet supplements. Cox HD and Eichner D Rapid Commun. Mass Spectrom. 27(19), 2170-8, (2013)

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Aggregation behavior and dynamics of synthetic amphiphiles that self-assemble to anion transporters. Elliott EK Chemistry 14(19), 5871-9, (2008)

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Chloroform: a review of its metabolism, teratogenic, mutagenic, and carcinogenic potential. Davidson IW, Sumner DD, and Parker JC Drug Chem. Toxicol. 5(1), 1-87, (1982)

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Ethanol teratogenesis in Japanese medaka: effects at the cellular level. Minghui Wu et al Comp. Biochem. Physiol. B Biochem. Mol. Biol. 149, 191-201, (2008)

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Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals. Ilaria Massarelli et al Eur. J. Med. Chem. 44, 3658-64, (2009)

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Chemical, biochemical and toxicological differences between carbon tetrachloride and chloroform. A critical review of recent investigations of these compounds in mammals. Hathway DE Arzneimittelforschung 24(2), 173-6, (1974)

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Fast transport of HCl across a hydrophobic layer over macroscopic distances by using a Pt(II) compound as the transporter. Giannetto A, Lanza S, Puntoriero F, et al. Chem. Commun. (Camb.) 49(69), 7611-3, (2013)

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Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell. D'Elia R BMC Genomics 10, 492, (2009)

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Neural computational prediction of oral drug absorption based on CODES 2D descriptors. A Guerra et al Eur. J. Med. Chem. 45, 930-40, (2010)

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Distributions and sea-to-air fluxes of chloroform, trichloroethylene, tetrachloroethylene, chlorodibromomethane and bromoform in the Yellow Sea and the East China Sea during spring. He Z, Yang GP, Lu XL, et al. Environ. Pollut. 177, 28-37, (2013)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Development of ultrasound-assisted emulsification microextraction for determination of thiocynate ion in human urine and saliva samples. Hashemi M, Daryanavard SM, and Abdolhosseini S J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 917-918, 5-10, (2013)

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Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα± gene expression. Evan Markegard et al PLoS ONE 6, e25540, (2011)

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Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Ifeoma O, Samuel O, Itohan AM, et al. Asian Pac. J. Trop. Med. 6(3), 169-75, (2013)

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AFM characterization of spin coated carboxylated polystyrene nanospheres/xyloglucan layers on mica and silicon. Lubambo AF, Lucyszyn N, Petzhold CL, et al. Carbohydr. Polym. 93(1), 240-5, (2013)

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Anti-proliferative and apoptotic activities of constituents of chloroform extract of Juglans regia leaves. Salimi M, Ardestaniyan MH, Mostafapour Kandelous H, et al. Cell Prolif. 47(2), 172-9, (2014)

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Nanoscale protein arrays of rich morphologies via self-assembly on chemically treated diblock copolymer surfaces. Song S, Milchak M, Zhou H, et al. Nanotechnology 24(9), 095601, (2013)

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The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models. Liu S, Yao Y, Lu S, et al. Toxicol. Appl. Pharmacol. 272(1), 230-7, (2013)

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Risk assessment of inhaled chloroform based on its mode of action. Wolf DC and Butterworth BE Toxicol. Pathol. 25(1), 49-52, (1997)

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Characterization of Methylocystis strain JTA1 isolated from aged refuse and its tolerance to chloroform. Zhao T, Zhang L, Zhang Y, et al. J. Environ. Sci. (China) 25(4), 770-5, (2013)

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Studies on effects of Andrographis paniculata (Burm.f.) and Andrographis lineata nees (Family: Acanthaceae) extracts against two mosquitoes Culex quinquefasciatus (Say.) and Aedes aegypti (Linn.). Renugadevi G, Ramanathan T, Shanmuga pR, et al. Asian Pac. J. Trop. Med. 6(3), 176-9, (2013)

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Peripheral ostectomy with the use of Carnoy's solution as a rational surgical approach to odontogenic keratocyst: a case report with a 5-year follow-up. Matijević S, Damjanović Z, Lazić Z, et al. Vojnosanit. Pregl. 69(12), 1101-5, (2012)

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Inhibitory and bactericidal activity of selected South African honeys and their solvent extracts against clinical isolates of Helicobacter pylori. Manyi-Loh CE, Clarke AM, Green E, et al. Pak. J. Pharm. Sci. 26(5), 897-906, (2013)

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Screening of solvent dependent antibacterial activity of Prunus domestica. Yaqeen Z, Naqvi NU, Sohail T, et al. Pak. J. Pharm. Sci. 26(2), 409-14, (2013)

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Inhibitory effects of Olea ferruginea crude leaves extract against some bacterial and fungal pathogen. Amin A, Khan MA, Shah S, et al. Pak. J. Pharm. Sci. 26(2), 251-4, (2013)

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Development and validation of stability-indicating TLC-densitometric method for determination of betaxolol with LC-ESI/MS analysis of degradation product. Kwiecień A, Krzek J, Walczak M, et al. Acta Pol. Pharm. 70(4), 643-52, (2013)

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Chloroform. Davison MH Br. J. Anaesth. 37(9), 655-60, (1965)

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Merck 14,2141

Beil. 1,IV,42

Fieser 1,29 / Fieser 1,130 / Fieser 1,30 / Fieser 3,140 / Fieser 4,22 / Fieser 5,28 / Fieser 8,92 / Fieser 12,517 / Fieser 14,167 / Fieser 15,84

Aldrich MSDS 1, 405:C / Corp MSDS 1 (1), 786:C / FT-IR 1 (1), 83:A / FT-IR 2 (1), 117:D / FT-NMR 1 (1), 122:A / IR-Spectra (2), 49:E / IR-Spectra (3), 51:G / NMR-Reference 2 (1), 81:C / RegBook 1 (1), 81:D / Sax 6, 722 / Structure Index 1, 9:D:10 / Vapor Phase 3, 116:C

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