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34865 Sigma-Aldrich

Tetrahydrofuran

inhibitor-free, CHROMASOLV® Plus, for HPLC, ≥99.9%

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, CHROMASOLV Plus, Chromatography Reagents & Solvents, HPLC & UHPLC Solvents (CHROMASOLV),
grade   CHROMASOLV® Plus
  for HPLC
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
assay   ≥99.9%
autoignition temp.   610 °F
expl. lim.   11.8 %
impurities   ≤0.0005% non-volatile matter
  ≤0.002% free acid (as CH3COOH)
  ≤0.05% peroxides (as H2O2)
  ≤0.05% water (Karl Fischer)
evapn. residue   ≤0.0005%
color   APHA: ≤10
refractive index   n20/D 1.407(lit.)
bp   65-67 °C(lit.)
mp   −108 °C(lit.)
density   0.889 g/mL at 25 °C(lit.)
absorption   absorption/212 nm ≤1.0
  absorption/245 nm ≤0.26
  absorption/250 nm ≤0.18
  absorption/275 nm ≤0.046
  absorption/300 nm ≤0.02
  absorption/315 nm ≤0.0044
  absorption/350 nm ≤0.005
  absorption/400 nm ≤0.005
UV absorption   λ: 245 nm Amax: ≤0.26
  λ: 275 nm Amax: ≤0.046
  λ: 315 μm Amax: ≤0.0044
suitability   complies for IR spectroscopy

Description

Application

Suitable for HPLC, spectrophotometry, environmental testing

Packaging

1, 6×1, 2, 4, 4×4 L in glass bottle

20 L in Nowpak™

100, 12×100 mL in glass bottle

200 L in Pure-Pac™ 1

Legal Information

CHROMASOLV is a registered trademark of Sigma-Aldrich Laborchemikalien GmbH

Price and Availability

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anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

Tetrahydrofuran

CHROMASOLV® Plus, for HPLC, ≥99.9%, inhibitor-free

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contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Supplemental Hazard Statements 
May form explosive peroxides.
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
13-16-29-33-36-37-46
RIDADR 
UN 2056 3 / PGII
WGK Germany 
1
RTECS 
LU5950000
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Tetrahydrofuran Using Karl Fischer Titration

Ethers behave similarly to hydrocarbons. They are mostly adequately soluble in methanol. Only long chain ethers require the addition of propanol or chloroform as solubilizers. Double bonds can someti...
Keywords: Solvents, Titrations

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Familial giant cell hepatitis associated with synthesis of 3 beta, 7 alpha-dihydroxy-and 3 beta,7 alpha, 12 alpha-trihydroxy-5-cholenoic acids. Clayton PT, Leonard JV, Lawson AM, et al. J. Clin. Invest. 79(4), 1031-8, (1987)

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Total, elastic, and inelastic cross sections for positron and electron collisions with tetrahydrofuran. Chiari L, Anderson E, Tattersall W, et al. J. Chem. Phys. 138(7), 074301, (2013)

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Biological monitoring of occupational exposure to tetrahydrofuran. Ong CN, Chia SE, Phoon WH, et al. Br. J. Ind. Med. 48(9), 616-21, (1991)

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Three-dimensional imaging of solvent-cleared organs using 3DISCO. Ertürk A, Becker K, Jährling N, et al. Nat. Protoc. 7(11), 1983-95, (2012)

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Tetrahydrofuran-containing macrolides: a fascinating gift from the deep sea. Lorente A, Lamariano-Merketegi J, Albericio F, et al. Chem. Rev. 113(7), 4567-610, (2013)

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Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Ilett KF, Ethell BT, Maggs JL, et al. Drug Metab. Dispos. 30(9), 1005-12, (2002)

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Low-energy electron scattering by cellulose and hemicellulose components. de Oliveira EM, da Costa RF, Sanchez Sd, et al. Phys. Chem. Chem. Phys. 15(5), 1682-9, (2013)

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Chiral separations by HPLC on immobilized polysaccharide chiral stationary phases. Ali I, Al-Othman ZA, and Aboul-Enein HY Methods Mol. Biol. 970, 127-35, (2013)

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International Conference on Harmonisation; final recommendations on the revision of the permitted daily exposures for two solvents, n-methylpyrrolidone and tetrahydrofuran, according to the maintenance procedures for the guidance Q3C Impurities: Residual Solvents; Availability. Notice. Fed. Regist. 68(219), 64352-3, (2003)

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The development of a method to quantify encapsulated and free prednisolone phosphate in liposomal formulations. Smits EA, Smits CJ, and Vromans H J. Pharm. Biomed. Anal. 75, 47-54, (2013)

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Taming of fluoroform: direct nucleophilic trifluoromethylation of Si, B, S, and C centers. Prakash GK, Jog PV, Batamack PT, et al. Science 338(6112), 1324-7, (2012)

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Direct functionalization of tetrahydrofuran and 1,4-dioxane: nickel-catalyzed oxidative C(sp3)-H arylation. Liu D, Liu C, Li H, et al. Angew. Chem. Int. Ed. Engl. 52(16), 4453-6, (2013)

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Enhanced mobility of fullerene (C60) nanoparticles in the presence of stabilizing agents. Wang Y, Li Y, Costanza J, et al. Environ. Sci. Technol. 46(21), 11761-9, (2012)

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Kinetics of 1,4-dioxane biodegradation by monooxygenase-expressing bacteria. Mahendra S and Alvarez-Cohen L Environ. Sci. Technol. 40(17), 5435-42, (2006)

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Tetrahydrofuran poisoning after occupational exposure. Garnier R, Rosenberg N, Puissant JM, et al. Br. J. Ind. Med. 46(9), 677-8, (1989)

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Reduced bacterial adhesion to fibrinogen-coated substrates via nitric oxide release. Charville GW Biomaterials 29(30), 4039-44, (2008)

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Diffusive hydrogen inter-cage migration in hydrogen and hydrogen-tetrahydrofuran clathrate hydrates. Cao H, English NJ, and MacElroy JM J. Chem. Phys. 138(9), 094507, (2013)

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Production of all trans-beta-carotene by using impinging flow of supercritical carbon dioxide anti-solvent pulverization. Shen YC, Chng LM, Wang YC, et al. J. Chromatogr. A 1270, 1-8, (2012)

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Determination of mexiletine in biological fluids by high-performance liquid chromatography. Breithaupt H and Wilfling M J. Chromatogr. A 230(1), 97-105, (1982)

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Toward prediction of alkane/water partition coefficients. Anita Toulmin et al J. Med. Chem. 51, 3720-30, (2008)

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Hollow interior structure of spin-coated polymer thin films revealed by ToF-SIMS three-dimensional imaging. Ren X, Weng LT, Chan CM, et al. Anal. Chem. 84(20), 8497-504, (2012)

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Vibrational Raman spectra of hydrogen clathrate hydrates from density functional theory. Ramya KR and Venkatnathan A J. Chem. Phys. 138(12), 124305, (2013)

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Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran. Agniswamy J, Shen CH, Wang YF, et al. J. Med. Chem. 56(10), 4017-27, (2013)

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Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance. Ghosh AK, Ramu Sridhar P, Kumaragurubaran N, et al. ChemMedChem 1(9), 939-50, (2006)

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Gymnothelignans A-O: conformation and absolute configuration analyses of lignans bearing tetrahydrofuran from Gymnotheca chinensis. He D, Ding L, Xu H, et al. J. Org. Chem. 77(19), 8435-43, (2012)

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Designing secondary structures: 5-azidomethyl tetrahydrofuran-2-carboxylates as carbohydrate-derived dipeptide isosteres. Smith MD and Fleet GW J. Pept. Sci. 5(10), 425-41, (1999)

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Tetrahydrofuran, tetrahydropyran, triazoles and related heterocyclic derivatives as HIV protease inhibitors. Ghosh AK and Anderson DD Future Med. Chem. 3(9), 1181-97, (2011)

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Solvent effect in reactions using Stryker's reagent. Sass DC, Heleno VC, Cavalcante S, et al. J. Org. Chem. 77(20), 9374-8, (2012)

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Determination of heptylphysostigmine in plasma by high-performance liquid chromatography with electrochemical detection. Unni LK and Becker RE J. Chromatogr. A 573(2), 275-81, (1992)

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Critical chromatography in ternary solvents. Mlynek M and Radke W J. Chromatogr. A 1284, 112-7, (2013)

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Synthesis and biological evaluation as microtubule-active agents of several tetrahydrofuran and spiroacetal derivatives. Carda M, Murga J, Paños J, et al. Curr. Med. Chem. 20(9), 1173-82, (2013)

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Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals. Ilaria Massarelli et al Eur. J. Med. Chem. 44, 3658-64, (2009)

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Identification and quantitation of xenobiotics by 1H NMR spectroscopy in poisoning cases. Imbenotte M, Azaroual N, Cartigny B, et al. Forensic Sci. Int. 133(1-2), 132-5, (2003)

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Site-isolated redox reactivity in a trinuclear iron complex. Eames EV and Betley TA Inorg. Chem. 51(19), 10274-8, (2012)

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Simultaneous determination of vitamins C, E and beta-carotene in human plasma by high-performance liquid chromatography with photodiode-array detection. Zhao B, Tham SY, Lu J, et al. J. Pharm. Pharm. Sci. 7(2), 200-4, (2004)

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Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis. Lu D, Silhan J, MacDonald JT, et al. Proc. Natl. Acad. Sci. U. S. A. 109(42), 16852-7, (2012)

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The effect of tetrahydrofuran on biological systems: does a hepatotoxic potential exist? Moody DE Drug Chem. Toxicol. 14(4), 319-42, (1991)

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Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

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Metabolic disposition and pharmacokinetics of [14C]-amprenavir, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, administered as a single oral dose to healthy male subjects. Sadler BM, Chittick GE, Polk RE, et al. J. Clin. Pharmacol. 41(4), 386-96, (2001)

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Chemoenzymatic synthesis of trans-tetrahydrofuran cores of annonaceous acetogenins from bromobenzene. Ramos JC, Brovetto M, and Seoane GA Org. Lett. 15(8), 1982-5, (2013)

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Metabolism of a serotonin-4 receptor partial agonist 4-{4-[4-tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (TBPT): identification of an unusual pharmacologically active cyclized oxazolidine metabolite in human. Sawant-Basak A, Coffman KJ, Walker GS, et al. J. Pharm. Sci. 102(9), 3277-93, (2013)

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Controlling morphology and chain aggregation in semiconducting conjugated polymers: the role of solvent on optical gain in MEH-PPV. Lampert ZE, Reynolds CL, Papanikolas JM, et al. J. Phys. Chem. B 116(42), 12835-41, (2012)

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Chiral recognition of amino acids by use of a fluorescent resorcinarene. GERALD I. RICHARD et al Appl. Spectroscopy 62, 476-80, (2009)

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Weak coordination of neutral S- and O-donor proximal ligands to a ferrous porphyrin nitrosyl. Characterization of 6-coordinate complexes at low T. Martirosyan GG, Kurtikyan TS, Azizyan AS, et al. J. Inorg. Biochem. 121, 129-33, (2013)

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Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions. Cunniffe S, O'Neill P, Greenberg MM, et al. Mutat. Res. Fundam. Mol. Mech. Mutagen. 762, 32-9, (2014)

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Biodegradation of tetrahydrofuran and 1,4-dioxane by soluble diiron monooxygenase in Pseudonocardia sp. strain ENV478. Masuda H, McClay K, Steffan RJ, et al. J. Mol. Microbiol. Biotechnol. 22(5), 312-6, (2012)

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Comparison of the reactivity of the three distonic isomers of the pyridine radical cation toward tetrahydrofuran in solution and in the gas phase. Widjaja F, Jin Z, Nash JJ, et al. J. Am. Soc. Mass Spectrom. 24(4), 469-80, (2013)

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Structure of a piperidine-modified calix[4]arene derivative and spectral resolution of its interaction with rare earth metals with chemometric methods. Wang L, Wang X, and Wang Y Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 105, 62-6, (2013)

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Two new compounds from Schisandra glaucescens. Zhang PP, Gao SS, Zhang TT, et al. J. Asian Nat. Prod. Res. 15(5), 466-72, (2013)

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Chemical shifts of phenolic monomers in solution and implications for addition and self-condensation. Haupt RA and Renneckar S Magn. Reson. Chem. 51(2), 95-101, (2013)

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Formation of itraconazole-succinic acid cocrystals by gas antisolvent cocrystallization. Ober CA and Gupta RB AAPS PharmSciTech 13(4), 1396-406, (2012)

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Merck 14,9211

Beil. 17,V,1,27

Fieser 1,1140 / Fieser 2,398 / Fieser 3,278 / Fieser 5,649 / Fieser 6,570

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