360570 Sigma-Aldrich


ACS reagent, ≥99.0%



Related Categories ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NPT Threads,
grade   ACS reagent
vapor density   2.72 (vs air)
vapor pressure   10 mmHg ( 13.2 °C)
  20 mmHg ( 25 °C)
assay   ≥99.0%
autoignition temp.   899 °F
expl. lim.   12.4 %
impurities   Reducing substances, passes test
  ≤0.002% NH3
  0.1% water
evapn. residue   ≤0.002%
refractive index   n20/D 1.509(lit.)
bp   115 °C(lit.)
mp   −42 °C(lit.)
solubility   water: soluble
density   0.978 g/mL at 25 °C(lit.)
anion traces   chloride (Cl-): ≤0.001%
  sulfate (SO42-): ≤0.001%
cation traces   Cu: ≤5 ppm


Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.


1, 2.5, 4×4 L in glass bottle

View returnable container options.

100, 500 mL in glass bottle

18, 20 L in steel drum


Pyridine may be used in the synthesis of the following:
• complexes with cobalt(II) halides1
• pyridine-d5, a deuterated form of pyridine2
• ionic liquid matrices (ILMs)3

General description

Pyridine (Pyr) is a nitrogen containing six membered heterocyclic compound commonly used as a base. It is a colorless liquid with a fishy odor. Pyridine moiety is present as a major component in a number of compounds like pyridine nucleotides,4 pyridine alkaloids,5 pyridine-based polymers6 and pyridine-containing macrocycles.7 It has wide application as a solvent, catalyst and as an intermediate for synthesis.8 IR, Raman and UV spectra of pyridine has been analyzed and the values obtained were used to calculate its thermodynamic properties.9 Photodegradation10 and bacterial degradation of Pyr has been studied.11

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Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
UN 1282 3 / PGII
WGK Germany 
Flash Point(F) 
62.6 °F
Flash Point(C) 
17 °C


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Determination of Water Content in Pyridine Using Karl Fischer Titration

Nitrogen compounds, acid amides and weakly basic amines (heterocyclenes) give no problems. They can be titrated according to the standard procedures. Strongly basic amines alter the pH value and must...
Keywords: Titrations

EPA Method 335.4 Product Selection Guide

This product selection guide is designed to simplify the ordering of products for EPA Method 335.4. This method is for the determination of total cyanide in various water and waste samples.

Knoevenagel Condensation Reaction

The Knoevenagel Condensation Reaction is a classic organic synthesis, described by Emil Knoevenagel in the 1890’s. The Knoevenagel reaction is a modified Aldol Condensation with a nucleophilic additi...
Keywords: Aldol condensation, C-C bond formation, Condensations, Dehydration reaction, Knoevenagel Condensation, Nucleophilic additions, Organic synthesis

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Peer-Reviewed Papers


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1. The thermal decomposition of metal complexes-III: The decomposition of some pyridine and substituted-pyridine complexes of cobalt (II) halides. Allan JR, et al. J. Inorg. Nucl. Chem. 26(11), 1895-1902, (1964)

2. The Vibrational Spectra of Pyridine and Pyridine-d 5. Corrsin L, et al. J. Chem. Phys. 21(7), 1170-1176, (1953)

4. Pyridine coenzymes of subcellular tissue fractions. Jacobson KB and Kaplan NO. J. Biol. Chem. 226(2), 603-613, (1957)

5. Cyclostellettamines AF, pyridine alkaloids which inhibit binding of methyl quinuclidinyl benzilate (QNB) to muscarinic acetylcholine receptors, from the marine sponge, Stelletta maxima. Fusetani N, et al. Tetrahedron Lett. 35(23), 3967-3970, (1994)

6. Absorption and luminescence of pyridine-based polymers. Jessen SW, et al. Synthetic Metals 84(1), 501-506, (1997)

7. Nickel (II) and copper (II) complexes with pyridine-containing macrocycles bearing an aminopropyl pendant arm: synthesis, characterization, and modifications of the pendant amino group. Herrera AM, et al. Dalton Trans. 5, 846-856, (2003)

9. The vibrational spectrum of pyridine and the thermodynamic properties of pyridine vapors. Kline Jr CH and Turkevich J. J. Chem. Phys. 12(7), 300-309, (1944)

11. Bacterial degradation of pyridine, indole, quinoline, and their derivatives under different redox conditions. Fetzner, S. Appl. Microbiol. Biotechnol. 49(3), 237-250, (1998)

Impact of pore connectivity on the design of long-lived zeolite catalysts. Milina M, Mitchell S, Cooke D, et al. Angew. Chem. Int. Ed. Engl. 54(5), 1591-4, (2015)


Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese. Badoud F, Lam KP, DiBattista A, et al. J. Proteome Res. 13(7), 3455-66, (2014)


Gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based metabolomics for comparison of caffeinated and decaffeinated coffee and its implications for Alzheimer's disease. Chang KL, Ho PC, et al. PLoS ONE 9(8), e104621, (2014)


Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary sclerosing cholangitis. Wunsch E, Trottier J, Milkiewicz M, et al. Hepatology 60(3), 931-40, (2014)


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Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins. Farsalinos KE, Kistler KA, Gillman G, et al. Nicotine Tob. Res. 17(2), 168-74, (2015)


Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography. Bressanello D, Liberto E, Collino M, et al. J. Chromatogr. A. 1361, 265-76, (2014)


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Merck 14,7970

Beil. 20,V,5,160

Fieser 1,958 / Fieser 2,349 / Fieser 4,414 / Fieser 6,497 / Fieser 11,448 / Fieser 12,416

Aldrich MSDS 1, 1559:C / Arctander, 2776 / Corp MSDS 1 (2), 2989:D / FT-IR 1 (2), 729:A / FT-IR 2 (3), 3698:A / FT-NMR 1 (3), 233:A / Fenaroli / IR-Spectra (2), 1138:A / IR-Spectra (3), 1306:A / NMR-Reference 2 (2), 611:A / RegBook 76 (2), 2489:A / RegBook 1 (2), 2489:A / Sax 6, 2325 / Structure Index 1, 393:A:1 / Vapor Phase 3, 1513:A

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