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3802 Sigma-Aldrich

Glutaraldehyde solution

for in vitro diagnostic use

Synonym: Glutaric dialdehyde solution, Pentane-1,5-dial

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Description

Other Notes

Glutaraldehyde, 4%, in borate buffer, pH 7.6.

Application

Glutaraldehyde solution has been used for the enzyme and redox mediator immobilization as well as for depositing colloidal gold (Aucoll) onto the cyst self-assembled monolayers (SAMs). The product has also been used along with tricalcium phosphate to form a glutaraldehyde cross linked gelatin (GTG) scaffold incorporated with bone morphogenetic proteins (BMPs), which in turn is utilized as a substitute for bone tissue engineering.

Biochem/physiol Actions

Glutaraldehyde is a low molecular weight dialdehyde that possess potent bactericidal, fungicidal, mycobactericidal, sporicidal, and virucidal activity. It serves as a fixative in bioprostheses and its cross-linking property impacts the biological performance of numerous bioprostheses such as tissue heart valves, vascular grafts, pericardial patches, tendon grafts and aids investigation of drug delivery matrices.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
1
Protocols & Articles

Articles

Determination of Water Content in Glutardialdehyde solution 50% Using Karl Fischer Titration

Aldehydes have a tendency to form acetals. At the same time water is formed. Water is bound in the bisulfite addition. Short chain aldehydes show a strong tendency to acetal formation, aromatic aldeh...
Keywords: Pharmaceutical, Titrations

Tailoring Collagen-Based Matrices for Regenerative Medicine and Tissue Engineering

Jiayu Leong,1 Liam Grover,2 Hyunjoon Kong1* 1Department of Chemical and Biomolecular Engineering University of Illinois, Urbana-Champaign, IL 61801 USA 2University of Birmingham, UK *Email: hjkong06@...
Keywords: Adhesion, Adsorption, Aminations, Bacterial conjugations, Biomaterials, Building blocks, Cell culture, Clinical, Deaminations, Degradations, Deposition, Diffusion, Growth factors, Hydroxylations, Immobilization, Ligands, Methylations, Michael reaction, PAGE, Purification, Recombination, Reductive aminations, Transfection

Peer-Reviewed Papers
15

References

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