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3802 Sigma-Aldrich

Glutaraldehyde solution

for in vitro diagnostic use

Synonym: Glutaric dialdehyde solution, Pentane-1,5-dial

  • CAS Number 111-30-8

  • Linear Formula OHC(CH2)3CHO

  • Molecular Weight 100.12

  •  Beilstein Registry Number 605390

  •  MDL number MFCD00007025

  •  PubChem Substance ID 24863726

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Properties

Related Categories Aldehydes, Biochemicals and Reagents, Building Blocks, C1 to C6, Carbohydrates,
Quality Level   GMP-IVD
IVD   for in vitro diagnostic use
solubility   H2O: soluble
  benzene: soluble
  diethyl ether: soluble
  ethanol: soluble
storage temp.   2-8°C

Description

Other Notes

Glutaraldehyde, 4%, in borate buffer, pH 7.6.

Application

Glutaraldehyde solution has been used for the enzyme and redox mediator immobilization as well as for depositing colloidal gold (Aucoll) onto the cyst self-assembled monolayers (SAMs).1 The product has also been used along with tricalcium phosphate to form a glutaraldehyde cross linked gelatin (GTG) scaffold incorporated with bone morphogenetic proteins (BMPs), which in turn is utilized as a substitute for bone tissue engineering.2

Biochem/physiol Actions

Glutaraldehyde is a low molecular weight dialdehyde that possess potent bactericidal, fungicidal, mycobactericidal, sporicidal, and virucidal activity.3 It serves as a fixative in bioprostheses and its cross-linking property impacts the biological performance of numerous bioprostheses such as tissue heart valves, vascular grafts, pericardial patches, tendon grafts and aids investigation of drug delivery matrices.4

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
23-26-36/37/39-45
RIDADR 
UN 3082 9 / PGIII
WGK Germany 
1

Protocols & Articles

Articles

Determination of Water Content in Glutardialdehyde solution 50% Using Karl Fischer Titration

Aldehydes have a tendency to form acetals. At the same time water is formed. Water is bound in the bisulfite addition. Short chain aldehydes show a strong tendency to acetal formation, aromatic aldeh...
Keywords: Pharmaceutical, Titrations

Peer-Reviewed Papers

References

Set your institution to view full text papers.

1. A comparison of different strategies for the construction of amperometric enzyme biosensors using gold nanoparticle-modified electrodes. Mena ML, Yáñez-Sedeño P, and Pingarrón JM Anal. Biochem. 336(1), 20-7, (2005)

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2. Tricalcium phosphate and glutaraldehyde crosslinked gelatin incorporating bone morphogenetic protein--a viable scaffold for bone tissue engineering. Yang SH, Hsu CK, Wang KC, et al. J. Biomed. Mater. Res. B. Appl. Biomater. 74(1), 468-75, (2005)

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3. Glutaraldehyde: current status and uses. Russell AD Infect. Control Hosp. Epidemiol. 15(11), 724-33, (1994)

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4. Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices. Jayakrishnan A and Jameela SR Biomaterials 17(5), 471-84, (1996)

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Range finding toxicity data--List VI H. F. Smyth Am. Ind. Hyg. Assoc. J. 23, 95, (1962)

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Graphene-based photothermal agent for rapid and effective killing of bacteria. Wu MC, Deokar AR, Liao JH, et al. ACS Nano 7(2), 1281-90, (2013)

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Development of a continuous bioconversion system using a thermophilic whole-cell biocatalyst. Ninh PH, Honda K, Yokohigashi Y, et al. Appl. Environ. Microbiol. 79(6), 1996-2001, (2013)

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Pathogenic Neisseria hitchhike on the uropod of human neutrophils. Söderholm N, Vielfort K, Hultenby K, et al. PLoS ONE 6(9), e24353, (2011)

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New engineering treatment of bovine pericardium confers outstanding resistance to calcification in mitral and pulmonary implantations in a juvenile sheep model. Brizard CP, Brink J, Horton SB, et al. J. Thorac. Cardiovasc. Surg. 148(6), 3194-201, (2014)

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Wetting characteristics of addition silicon materials subjected to immersion disinfection--an in-vitro study. Shetty SR, Kamat G, and Shetty R Eur. J. Prosthodont. Restor. Dent. 21(3), 98-104, (2013)

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Relation between handling characteristics and application time of four photo-polymerized resin composites. Roulet JF, Geraldeli S, Sensi L, et al. Chin. J. Dent. Res. 16(1), 55-61, (2013)

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Clinical uses of glutaraldehyde/2-hydroxyethylmethacrylate (GLUMA). Larson TD Northwest Dent. 92(2), 27-30, (2013)

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Invited commentary. Punjabi PP Ann. Thorac. Surg. 95(6), 2006, (2013)

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Adverse staff health outcomes associated with endoscope reprocessing. Gutterman E, Jorgensen L, Mitchell A, et al. Biomed. Instrum. Technol. 47(2), 172-9, (2013)

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Scanning electron microscopy evaluation of endothelialized tissue-engineered constructs. Johnson SL Methods Mol. Biol. 1001, 325-40, (2013)

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Clinical and radiographic evaluation of pulpotomies in primary molars with formocresol, glutaraldehyde and ferric sulphate. Havale R, Anegundi RT, Indushekar K, et al. Oral Health Dent. Manag. 12(1), 24-31, (2013)

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Quantitative heterogeneous immunoassays in protein modified polydimethylsiloxane microfluidic channels for rapid detection of disease biomarkers. Li P Methods Mol. Biol. 949, 335-47, (2013)

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Stromagenesis During Tumorigenesis: Characterization Of Tumor-associated Fibroblasts And Stroma-derived 3D Matrices. Castelló-Cros, R., and Cukierman, E. Methods Mol. Biol. 522, 275-305, (2009)

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A total of 404 cases of aortic valve reconstruction with glutaraldehyde-treated autologous pericardium. Ozaki S, Kawase I, Yamashita H, et al. J. Thorac. Cardiovasc. Surg. 147(1), 301-6, (2014)

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy Lombard, D.B., et al. Proc. Natl. Acad. Sci. U. S. A. 105, 3374-3379, (2008)

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An in vitro study on the dimensional stability of a vinyl polyether silicone impression material over a prolonged storage period. Nassar U, Oko A, Adeeb S, et al. J. Prosthet. Dent. 109(3), 172-8, (2013)

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Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Kaity S, Isaac J, and Ghosh A Carbohydr. Polym. 94(1), 456-67, (2013)

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Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states. Dash MB J. Neurosci. 29(3), 620-9, (2009)

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Covalent immobilization of β-glucosidase on magnetic particles for lignocellulose hydrolysis. Alftrén J and Hobley TJ Appl. Biochem. Biotechnol. 169(7), 2076-87, (2013)

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Mapping of the chaperone AcrH binding regions of translocators AopB and AopD and characterization of oligomeric and metastable AcrH-AopB-AopD complexes in the type III secretion system of Aeromonas hydrophila. Tan YW Protein Sci. 18(8), 1724-34, (2009)

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Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. Kita-Matsuo, H PLoS ONE 4(4), e5046, (2009)

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Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles. Jana S, Saha A, Nayak AK, et al. Colloids Surf. B Biointerfaces 105, 303-9, (2013)

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Microfabricated electrospun collagen membranes for 3-D cancer models and drug screening applications. Hartman O Biomacromolecules 10(8), 2019-32, (2009)

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Glutaraldehyde-crosslinked chitosan beads for sorptive separation of Au(III) and Pd(II): opening a way to design reduction-coupled selectivity-tunable sorbents for separation of precious metals. Park SI, Kwak IS, Won SW, et al. J. Hazard. Mater. 248-249, 211-8, (2013)

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The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding. Chen BJ J. Virol. 82(20), 10059-70, (2008)

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One-pot bioconversion of sucrose to trehalose using enzymatic sequential reactions in combined cross-linked enzyme aggregates. Jung DH, Jung JH, Seo DH, et al. Bioresour. Technol. 130, 801-4, (2013)

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Role of porins in the susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to aldehyde-based disinfectants and drugs. Zuzana Svetlíková et al Antimicrob. Agents Chemother. 53, 4015-8, (2009)

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Bacterial inclusion bodies as potential synthetic devices for pathogen recognition and a therapeutic substance release. Talafová K, Hrabárová E, Chorvát D, et al. Microb. Cell Fact. 12, 16, (2013)

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Mechanical, physical, antioxidant, and antimicrobial properties of gelatin films incorporated with thymol for potential use as nano wound dressing. Kavoosi G, Dadfar SM, and Purfard AM J. Food Sci. 78(2), E244-50, (2013)

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Roles of idiotype-specific t cells in myeloma cell growth and survival: Th1 and CTL cells are tumoricidal while Th2 cells promote tumor growth. Sungyoul Hong et al Cancer Res. 68, 8456-64, (2008)

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Assessing the impact of national level interventions on workplace respiratory disease in the UK: part 1--changes in workplace exposure legislation and market forces. Stocks SJ, McNamee R, Turner S, et al. Occup. Environ. Med. 70(7), 476-82, (2013)

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Late results of mitral valve repair with glutaraldehyde-treated autologous pericardium. Shomura Y, Okada Y, Nasu M, et al. Ann. Thorac. Surg. 95(6), 2000-5, (2013)

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Autofluorescence generation and elimination: a lesson from glutaraldehyde. Lee K, Choi S, Yang C, et al. Chem. Commun. (Camb.) 49(29), 3028-30, (2013)

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Short term inhalation toxicity of a liquid aerosol of glutaraldehyde-coated CdS/Cd(OH)2 core shell quantum dots in rats. Ma-Hock L, Farias PM, Hofmann T, et al. Toxicol. Lett. 225(1), 20-6, (2014)

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Proanthocyanidins rapidly stabilize the demineralized dentin layer. Liu Y, Dusevich V, and Wang Y J. Dent. Res. 92(8), 746-52, (2013)

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Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins. Stroud MJ, Kammerer RA, and Ballestrem C J. Biol. Chem. 286(28), 24987-95, (2011)

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Reductive glutaraldehydation of amine groups for identification of protein N-termini. Allison Russo et al J. Proteome Res. 7, 4178-82, (2009)

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The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance. Barbone D, Ryan JA, Kolhatkar N, et al. Cell Death Dis. 2, e174, (2011)

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A randomised single-blind comparison of the effectiveness of Tristel Fuse (chlorine dioxide) as an office-based fluid soak, with Cidex OPA (ortho-phthaldehyde) using an automated endoscopic reprocessor (AER) as high-level disinfection for flexible cystoscopes. Gilling PJ, Reuther RM, Addidle M, et al. BJU Int. 112 Suppl 2, 69-73, (2013)

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A novel reusable PAni-PVA-Amylase film: activity and analysis. Singh S, Saikia JP, and Buragohain AK Colloids Surf. B Biointerfaces 106, 46-50, (2013)

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Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Behesti H Dev. Biol. 333(2), 360-72, (2009)

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Clinical evaluation of chlorine dioxide for disinfection of dental instruments. Watamoto T, Egusa H, Sawase T, et al. Int. J. Prosthodont. 26(6), 541-4, (2013)

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Agents and trends in health care workers' occupational asthma. Walters GI, Moore VC, McGrath EE, et al. Occup. Med. (Lond.) 63(7), 513-6, (2013)

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Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles. Rai, A., et al. Cell. Mol. Life Sci. 68, 2751-67, (2011)

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Stability and mechanical evaluation of bovine pericardium cross-linked with polyurethane prepolymer in aqueous medium. Mendoza-Novelo B, Alvarado-Castro DI, Mata-Mata JL, et al. Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4), 2392-8, (2013)

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An analysis of OSHA inspections assessing contaminant exposures in general medical and surgical hospitals. Knight JL, Sleeth DK, Larson RR, et al. Workplace Health Saf. 61(4), 153-60, (2013)

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Lipid-induced peroxidation in the intestine is involved in glucose homeostasis imbalance in mice. Serino M PLoS ONE 6(6), e21184, (2011)

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Transient in vivo beta-globin production after lentiviral gene transfer to hematopoietic stem cells in the nonhuman primate. Hayakawa J Hum. Gene Ther. 20(6), 563-72, (2009)

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Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization. McDuff FK PLoS ONE 6(3), e17854, (2011)

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Structure of glutaraldehyde cross-linked ryanodine receptor. Strauss JD and Wagenknecht T J. Struct. Biol. 181(3), 300-6, (2013)

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Use of long-term cultured embryoid bodies may enhance cardiomyocyte differentiation by BMP2. Kim YY Yonsei Med. J. 49(5), 819-27, (2008)

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Removal of textile dye, direct red 23, with glutaraldehyde cross-linked magnetic chitosan beads. Sanlier SH, Ak G, Yilmaz H, et al. Prep Biochem Biotechnol. 43(2), 163-76, (2013)

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Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting. Rabai M, Meiselman HJ, Wenby RB, et al. Biorheology 49(5-6), 317-28, (2012)

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Mesoporous silicas synthesis and application for lignin peroxidase immobilization by covalent binding method. Hu Z, Xu L, and Wen X J. Environ. Sci. (China) 25(1), 181-7, (2013)

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Glutaraldehyde degradation in hospital wastewater by photoozonation. Kist LT, Rosa EC, Machado EL, et al. Environ. Technol. 34(17-20), 2579-86, (2013)

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Spatial calibration of structured illumination fluorescence microscopy using capillary tissue phantoms. Grace S. Lee et al Microsc. Res. Tech. 72, 85-92, (2008)

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Entrapped cell system for decentralized hospital wastewater treatment: inhibitory effect of disinfectants. Siripattanakul-Ratpukdi S Environ. Technol. 33(19-21), 2319-28, (2012)

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Disinfection of rigid nasal endoscopes following in vitro contamination with Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae. Bradford BD, Seiberling KA, Park FE, et al. JAMA Otolaryngol. Head Neck Surg. 139(6), 574-8, (2013)

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Site specific properties of carious dentin matrices biomodified with collagen cross-linkers. Bedran-Russo AK, Karol S, Pashley DH, et al. Am. J. Dent. 26(5), 244-8, (2013)

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CRC Handbook of Chemistry and Physics, (2010) 91

Merck 14,4472

Beil. 1,IV,3659

Fieser 1,411

Aldrich MSDS 1, 992:A / Corp MSDS 1 (1), 1779:A / FT-IR 1 (1), 480:C / FT-IR 2 (1), 753:C / RegBook 1 (1), 527:E / RegBook 1 (1), 527:D / Sax 6, 1478 / Sigma FT-IR 1 (2), 590:B

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