383120 Sigma-Aldrich

Sulfamic acid

ACS reagent, 99.3%

Synonym: Amidosulfonic acid



Related Categories Acids, Acids & Bases, Chemical Synthesis, Inorganic Acids, Synthetic Reagents More...
grade   ACS reagent
assay   99.3%
  99.3-100.3% dry basis (ACS specification)
impurities   ≤0.01% insolubles
ign. residue   ≤0.01%
mp   215-225 °C (dec.)(lit.)
solubility   water: soluble213 g/L at 20 °C
anion traces   chloride (Cl-): ≤0.001%
  sulfate (SO42-): ≤0.05%
cation traces   Fe: ≤5 ppm
  heavy metals (as Pb): ≤0.001%
Gene Information   human ... CA1(759), CA2(760)


Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.


100, 500 g in poly bottle


Sulfamic acid (H2NSO3H) may be used in the following studies:
• As catalyst in the synthesis of aryl-14H-dibenzo[a.j]xanthenes.1
• As green catalyst for the preparation of amide from ketoxime.2
• As ammonia equivalent in the regioselective synthesis of primary allylic amines, via allylic substitution reactions.3
• Synthesis of polysubstituted quinolones.4

Sulfamic acid may be used in the following processes:
• As a titrant in the determination of the burette injection volume and chemical calibration factor.
• To neutralize excess nitrous acid in the colorimetric paracetamol assay by modified Glynn and Kendal colorimetric method.
• To prevent endogenous mercury (Hg) loss during the urine Hg measurement by inductively coupled plasma mass spectrometry (ICP-MS) method.
• As an acid catalyst and a hypochlorite scavenger in the chlorite oxidation of dialdehyde cellulose (DAC).
• As a heterogeneous catalyst in the synthesis of polyhydroquinoline derivatives by Hantzsch condensation reaction.
• As catalyst in the degradation of bamboo fiber to 5-hydroxymethylfurfural (HMF).
• As an acid reagent in the determination of silicates in water samples based on centrifugal microfluidics.
• As catalyst in the synthesis of deazaoxaflavin at room temperature.

General description

Sulfamic acid (H2NSO3H) is widely used inorganic compound. It exists in zwitterionic form and neutral forms. Zwitterionic form has been reported to be is more stable than neutral form. Its industrial applications have been reported.5 It has various organic synthesis applications.3

Sulfamic acid is a strong inorganic acid. It is a hypochlorite scavenger. The ability of sulfamic acid to reduce nitrate to nitrogen gas under acidic condition has been utilized to denitrify nitrate-rich wastewater along with zinc powder.

Price and Availability

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
UN 2967 8 / PGIII
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


EPA Method 335.4 Product Selection Guide

This product selection guide is designed to simplify the ordering of products for EPA Method 335.4. This method is for the determination of total cyanide in various water and waste samples.

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Peer-Reviewed Papers


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1. Sulfamic acid: a novel and efficient catalyst for the synthesis of aryl-14H-dibenzo [a. j] xanthenes under conventional heating and microwave irradiation. Rajitha B, et al. Tetrahedron Lett. 46(50), 8691-8693, (2005)

2. Sulfamic acid as a cost-effective and recyclable catalyst for liquid Beckmann rearrangement, a green process to produce amides from ketoximes without waste. Wang B, et al. Tetrahedron Lett. 45(17), 3369-3372, (2004)

3. Iridium-catalyzed synthesis of primary allylic amines from allylic alcohols: sulfamic acid as ammonia equivalent. Angew. Chem. Int. Ed. Engl. 46, 3139, (2007)


4. Sulfamic acid: an efficient, cost-effective and recyclable solid acid catalyst for the Friedlander quinoline synthesis. Yadav JS, et al. Tetrahedron Lett. 46(42, 7249-7253, (2005)

5. Solvent effects. 2. Medium effect on the structure, energy, charge density, and vibrational frequencies of sulfamic acid. Wong MW, et al. J. Am. Chem. Soc. 114(2), 523-529, (1992)

Optimization of dicarboxylic acid cellulose synthesis: reaction stoichiometry and role of hypochlorite scavengers. Sirviö JA, Liimatainen H, Visanko M, et al. Carbohydr. Polym. 114, 73-7, (2014)


Trace elements and endometriosis: the ENDO study. Pollack AZ, Louis GM, Chen Z, et al. Reprod. Toxicol. 42, 41-8, (2013)


Lab-on-a-disc for simultaneous determination of nutrients in water. Hwang H, Kim Y, Cho J, et al. Anal. Chem. 85(5), 2954-60, (2013)


Calibration of nanowatt isothermal titration calorimeters with overflow reaction vessels. Demarse NA, Quinn CF, Eggett DL, et al. Anal. Biochem. 417(2), 247-55, (2011)


A modified low-cost colorimetric method for paracetamol (acetaminophen) measurement in plasma. Shihana F, Dissanayake D, Dargan P, et al. Clin. Toxicol. (Phila.) 48(1), 42-6, (2010)


Denitrification of simulated nitrate-rich wastewater using sulfamic acid and zinc scrap. Jang JH, et al. Chemical Papers (Slovak Acad. Sci.) 65(4), 437-446, (2011)

Sulphamic acid assisted synthesis of polyhydroquinolines via Hantzsch multicomponent reaction: A green approach. Lambat T, et al. J. Chem. Pharm. Res. 6(4), 888-892, (2014)

Conversion of bamboo fiber into 5-hydroxymethylfurfural catalyzed by sulfamic acid with microwave assistance in biphasic system. Sun J, et al. Ind. Crops Prod. 70, 266-271, (2015)

Sulfamic Acid: Efficient, Cost-Effective Catalyst for Facile Synthesis of Deazaoxaflavin at Ambient Temperature. Mane MM and Pore DM. Synth. Commun. 45(7), 868-876, (2015)

[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX. Can D, Spingler B, Schmutz P, et al. Angew. Chem. Int. Ed. Engl. 51(14), 3354-7, (2012)


Cobalt-catalyzed direct arylation and benzylation by C-H/C-O cleavage with sulfamates, carbamates, and phosphates. Song W and Ackermann L Angew. Chem. Int. Ed. Engl. 51(33), 8251-4, (2012)


Comparison of arylboron-based nucleophiles in Ni-catalyzed Suzuki-Miyaura cross-coupling with aryl mesylates and sulfamates. Zhang N, Hoffman DJ, Gutsche N, et al. J. Org. Chem. 77(14), 5956-64, (2012)


QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII. Tarko L and Supuran CT Bioorg. Med. Chem. 21(6), 1404-9, (2013)


Measurement of nitrosamine and nitramine formation from NOx reactions with amines during amine-based carbon dioxide capture for postcombustion carbon sequestration. Dai N, Shah AD, Hu L, et al. Environ. Sci. Technol. 46(17), 9793-801, (2012)


Nickel-catalyzed amination of aryl sulfamates and carbamates using an air-stable precatalyst. Hie L, Ramgren SD, Mesganaw T, et al. Org. Lett. 14(16), 4182-5, (2012)


Iron-catalyzed cross-coupling reactions of alkyl Grignards with aryl sulfamates and tosylates. Agrawal T and Cook SP Org. Lett. 15(1), 96-9, (2013)


Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer. Winum JY, Colinas PA, and Supuran CT Bioorg. Med. Chem. 21(6), 1419-26, (2013)


Palladium-catalyzed intramolecular diamination of acrylic esters using sulfamates as nitrogen source. Chávez P, Kirsch J, Streuff J, et al. J. Org. Chem. 77(4), 1922-30, (2012)


Total synthesis of (-)-kaitocephalin based on a Rh-catalyzed C-H amination. Takahashi K, Yamaguchi D, Ishihara J, et al. Org. Lett. 14(6), 1644-7, (2012)


Modular functionalization of allenes to aminated stereotriads. Adams CS, Boralsky LA, Guzei IA, et al. J. Am. Chem. Soc. 134(26), 10807-10, (2012)


Palladium-catalysed aminosulfonylation of aryl-, alkenyl- and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides Emmett, E. J., et al. Org. Biomol. Chem. 10, 4007-4014, (2012)


Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues. Chen, J.J., et al J. Biol. Chem. 286, 40867-40877, (2011)


Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines. Winum JY, Carta F, Ward C, et al. Bioorg. Med. Chem. Lett. 22(14), 4681-5, (2012)


Detection of the 1H and 15N NMR resonances of sulfamate groups in aqueous solution: a new tool for heparin and heparan sulfate characterization. Langeslay DJ, Beni S, and Larive CK Anal. Chem. 83(20), 8006-10, (2011)


Sulfamate proton solvent exchange in heparin oligosaccharides: evidence for a persistent hydrogen bond in the antithrombin-binding pentasaccharide Arixtra. Langeslay DJ, Young RP, Beni S, et al. Glycobiology 22(9), 1173-82, (2012)


Phosphine-catalyzed [3 + 2] cycloaddition of sulfamate-derived cyclic imines with allenoate: synthesis of sulfamate-fused dihydropyrroles. Yu H, Zhang L, Yang Z, et al. J. Org. Chem. 78(17), 8427-36, (2013)


Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors. Lopez M, Vu H, Wang CK, et al. J. Am. Chem. Soc. 133(45), 18452-62, (2011)


A modular synthesis of dithiocarbamate pendant unnatural α-amino acids. Saha A, Baig RB, Leazer J, et al. Chem. Commun. (Camb.) 48(71), 8889-91, (2012)


Potent inhibition of Norwalk virus by cyclic sulfamide derivatives. Dou D, Tiew KC, He G, et al. Bioorg. Med. Chem. 19(20), 5975-83, (2011)


Cloning, characterization and sulfonamide inhibition studies of an ?-carbonic anhydrase from the living fossil sponge Astrosclera willeyana. Anna Ohradanova et al Bioorg. Med. Chem. 20, 1403-10, (2012)


Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors. Edwards DR and Wolfenden R J. Org. Chem. 77(9), 4450-3, (2012)


Hydrolysis of N-alkyl sulfamates and the catalytic efficiency of an S-N cleaving sulfamidase. Lohman DC, Wolfenden R, and Edwards DR J. Org. Chem. 77(6), 2907-10, (2012)


Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria. Cherian PT, Yao J, Leonardi R, et al. Bioorg. Med. Chem. 20(16), 4985-94, (2012)


Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups. Reuillon T, Bertoli A, Griffin RJ, et al. Org. Biomol. Chem. 10(37), 7610-7, (2012)


Ethylenediammonium dication: H-bonded complexes with terephthalate, chloroacetate, phosphite, selenite and sulfamate anions. Detailed vibrational spectroscopic and theoretical studies of ethylenediammonium terephthalate. Marchewka MK and Drozd M Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 99, 223-33, (2012)


Merck 14,8921

Fieser 1,1117

Aldrich MSDS 1, 1627:A / Corp MSDS 1 (2), 3196:C / FT-IR 2 (3), 4710:D / FT-IR 1 (2), 1231:A / RegBook 1 (3), 3199:D / Sax 6, 2479 / Sigma FT-IR 1 (2), 1048:D / Structure Index 1, 509:B:2

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