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38399 Sigma-Aldrich

Diisopropylfluorophosphate

≥97.0% (GC)

Synonym: DFP, DIFP, Diisopropyl phosphorofluoridate, Phosphoric acid diisopropyl ester fluoride

  • CAS Number 55-91-4

  • Linear Formula [(CH3)2CHO]2POF

  • Molecular Weight 184.15

  •  Beilstein Registry Number 1723307

  •  EC Number 200-247-6

  •  MDL number MFCD00008873

  •  PubChem Substance ID 329755682

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Phosphorus Compounds, Phosphorus Halides More...
vapor pressure   0.58 mmHg ( 20 °C)
InChI Key   MUCZHBLJLSDCSD-UHFFFAOYSA-N
assay   ≥97.0% (GC)
refractive index   n20/D 1.385(lit.)
bp   62 °C/9 mmHg(lit.)
mp   −82 °C(lit.)
density   1.06 g/mL at 25 °C(lit.)
storage temp.   2-8°C
Gene Information   human ... PTGS1(5742), PTGS2(5743)

Description

Analysis Note

Typically used at a concentration of 0.10 mM. A safer alternative inhibitor for serine protease is phenylmethylsulfonyl fluoride (PMSF).

Other Notes

Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases); Inhibition of carboxypeptidase but not DAP I

Biochem/physiol Actions

Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3382 6.1 / PGI
WGK Germany 
3
RTECS 
TE5075000
Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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D0879 Diisopropylfluorophosphate

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