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394874 Sigma-Aldrich

1-(Trimethylsilyl)imidazole

for GC derivatization

Synonym: N-Trimethylsilylimidazole, TMSI, TSIM

  • CAS Number 18156-74-6

  • Empirical Formula (Hill Notation) C6H12N2Si

  • Molecular Weight 140.26

  •  Beilstein Registry Number 606148

  •  EC Number 242-040-3

  •  MDL number MFCD00005280

  •  PubChem Substance ID 329755874

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Properties

Related Categories Alcohols, Analytical Reagents, Analytical/Chromatography, Derivatization Reagents, Derivatization Reagents GC,
grade   for GC derivatization
InChI Key   YKFRUJSEPGHZFJ-UHFFFAOYSA-N
refractive index   n20/D 1.475(lit.)
bp   93-94 °C/14 mmHg(lit.)
density   0.956 g/mL at 25 °C(lit.)
derivatization reagent for   Silylations

Description

Other Notes

Reagent for trimethylsilyl and trimethylsilyl ether.

Same product — same quality — now Sigma-Aldrich brand

Packaging

10×1 mL in ampule

5, 25 mL in glass bottle

Application

1-(Trimethylsilyl) imidazole may be used for the synthesis an O-silylated derivative of a hexahomotriazacalix[3]arene. It may also be used for the silylation of Ti-MCM-41 catalyst, to study its effect on the olefin epoxidation with aqueous H2O2, 1-(Trimethylsilyl) imidazole was found to improve the hydrophobicity and the catalytic performance of Ti-MCM-41.

General description

1-(Trimethylsilyl)imidazole (TMSIM) has high silyl donor ability. It does not react with amino groups and also does not help in formation of enol-ether on unprotected ketone groups. It is useful as a silylating agent for ecdysones, norepinephrine, dopamine, steroids, sugars, sugar phosphates and ketose isomers.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993BF 3 / PGII
WGK Germany 
3
RTECS 
NI8700000
Flash Point(F) 
42.8 °F
Flash Point(C) 
6 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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