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402907 Sigma-Aldrich

Propionic acid

ACS reagent, ≥99.5%

Synonym: Acid C3, Propanoic acid, Propanyl acid

  • CAS Number 79-09-4

  • Linear Formula CH3CH2COOH

  • Molecular Weight 74.08

  •  Beilstein Registry Number 506071

  •  EC Number 201-176-3

  •  MDL number MFCD00002756

  •  PubChem Substance ID 24865136

  •  eCl@ss 39021305

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Properties

Related Categories Acids, Acids & Bases, Analytical Reagents, Analytical/Chromatography, Application Specific Reagents,
grade   ACS reagent
vapor density   2.55 (vs air)
vapor pressure   2.4 mmHg ( 20 °C)
assay   ≥99.5%
autoignition temp.   955 °F
expl. lim.   12.1 %
impurities   ≤0.002% Carbonyl compounds
  ≤0.10% Readily oxidizable substances (as HCOOH)
  ≤0.15% water
evapn. residue   ≤0.01%
color   APHA: ≤20
refractive index   n20/D 1.386(lit.)
bp   141 °C(lit.)
mp   −24-−23 °C(lit.)
density   0.993 g/mL at 25 °C(lit.)
cation traces   heavy metals (as Pb): ≤0.001%

Description

Packaging

100, 4×100, 500 mL in glass bottle

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3463 8/PG 2
WGK Germany 
1
RTECS 
UE595000
Flash Point(F) 
129.2 °F
Flash Point(C) 
54 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in Propionic acid Using Karl Fischer Titration

The determination of water in carboxylic acids is usually straightforward provided the substances are soluble. Strong acids must be neutralized. Acetic acid and related compounds have a tendency to u...
Keywords: Esterifications, Pharmaceutical, Titrations

Graphene Field Effect Transistors for Biological and Chemical Sensors

Victoria Tsai* and Bruce Willner Graphene Frontiers, Philadelphia, PA 19104, USA *Email: victoria@graphenefrontiers.com
Keywords: Adhesion, Chemical vapor deposition, Chromatin immunoprecipitation, Deposition, Drug discovery, Environmental, Evaporation, Ion-exchange chromatography, Nanomaterials, Nanotubes, Semiconductor, Separation

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Peer-Reviewed Papers

References

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Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Al-Lahham SH, Peppelenbosch MP, Roelofsen H, et al. Biochim. Biophys. Acta 1801(11), 1175-83, (2010)

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Understanding the human salivary metabolome. Takeda I, Stretch C, Barnaby P, et al. NMR Biomed. 22(6), 577-84, (2009)

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Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. Bindels LB, Porporato P, Dewulf EM, et al. Br. J. Cancer 107(8), 1337-44, (2012)

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Effects of butyrate and propionate on the adhesion, growth, cell cycle kinetics, and protein synthesis of cultured human gingival fibroblasts. Jeng JH, Chan CP, Ho YS, et al. J. Periodontol. 70(12), 1435-42, (1999)

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Propionic and butyric acids, formed in the caecum of rats fed highly fermentable dietary fibre, are reflected in portal and aortic serum. Jakobsdottir G, Jädert C, Holm L, et al. Br. J. Nutr. 110(9), 1565-72, (2013)

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Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. De Kanter R, De Jager MH, Draaisma AL, et al. Xenobiotica 32(5), 349-62, (2002)

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Assessment of atrophy of human skin caused by corticosteroids using chamber occlusion and suction blister techniques. Somerma S, Lassus A, and Salde L Acta Derm. Venereol. 64(1), 41-5, (1984)

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Sorption and solubility of self-etching adhesives immersed in organic acids present in oral biofilm. da Silva Nunes Gomes Miranda ME, de Oliveira Scudine KG, Noronha Filho JD, et al. J. Adhes. Dent. 16(2), 115-22, (2014)

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Compatible compositions based on aqueous polyurethane dispersions and sodium alginate. Daemi H, Barikani M, and Barmar M Carbohydr. Polym. 92(1), 490-6, (2013)

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Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Robertson MD, Bickerton AS, Dennis AL, et al. Am. J. Clin. Nutr. 82(3), 559-67, (2005)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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A circular dichroism and fluorescence quenching study of the interactions between rhodium(II) complexes and human serum albumin. Espósito BP, Faljoni-Alário A, de Menezes JF, et al. J. Inorg. Biochem. 75(1), 55-61, (1999)

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Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Pluznick JL, Protzko RJ, Gevorgyan H, et al. Proc. Natl. Acad. Sci. U. S. A. 110(11), 4410-5, (2013)

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Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Frye RE, Melnyk S, and Macfabe DF Transl. Psychiatry 3, e220, (2013)

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Synaptic signaling between neurons and glia. Lin SC and Bergles DE Glia 47(3), 290-8, (2004)

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1H and (13)C NMR spectroscopic analysis of human saliva. Silwood CJ, Lynch E, Claxson AW, et al. J. Dent. Res. 81(6), 422-7, (2002)

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The genome sequence of Propionibacterium acidipropionici provides insights into its biotechnological and industrial potential. Parizzi LP, Grassi MC, Llerena LA, et al. BMC Genomics 13, 562, (2012)

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Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. Gamze Bora-Tatar et al Bioorg. Med. Chem. 17, 5219-28, (2009)

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Microbial production of propionic acid from propionibacteria: current state, challenges and perspectives. Liu L, Zhu Y, Li J, et al. Crit. Rev. Biotechnol. 32(4), 374-81, (2012)

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Liquid chromatography-mass spectrometry for metabolic footprinting of co-cultures of lactic and propionic acid bacteria. Honoré AH, Thorsen M, and Skov T Anal. Bioanal. Chem 405(25), 8151-70, (2013)

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'Classical' organic acidurias, propionic aciduria, methylmalonic aciduria and isovaleric aciduria: long-term outcome and effects of expanded newborn screening using tandem mass spectrometry. Dionisi-Vici C, Deodato F, Röschinger W, et al. J. Inherit. Metab. Dis. 29(2-3), 383-9, (2006)

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Enhancement of propionic acid fraction in volatile fatty acids produced from sludge fermentation by the use of food waste and Propionibacterium acidipropionici. Chen Y, Li X, Zheng X, et al. Water Res. 47(2), 615-22, (2013)

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Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography trace for measurement of acetylcholinesterase activity in human brain. Koeppe RA, Frey KA, Snyder SE, et al. J. Cereb. Blood Flow Metab. 19(10), 1150-63, (1999)

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Methylmalonic and propionic acidaemias: management and outcome. de Baulny HO, Benoist JF, Rigal O, et al. J. Inherit. Metab. Dis. 28(3), 415-23, (2005)

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The dansyl chloride technique for stratum corneum renewal as an indicator of changes in epidermal mitotic activity following topical treatment. Ridge BD, Batt MD, Palmer HE, et al. Br. J. Dermatol. 118(2), 167-74, (1988)

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HPLC separation of enantiomers of chiral arylpropionic acid derivatives using polysaccharide-based chiral columns and normal-phase eluents with emphasis on elution order. Matarashvili I, Chankvetadze L, Fanali S, et al. J. Sep. Sci. 36(1), 140-7, (2013)

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Identification and quantification of key microbial trophic groups of methanogenic glucose degradation in an anaerobic digester sludge. Ito T, Yoshiguchi K, Ariesyady HD, et al. Bioresour. Technol. 123, 599-607, (2012)

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New hyaluronic acid based brush copolymers synthesized by atom transfer radical polymerization. Pitarresi G, Fiorica C, Licciardi M, et al. Carbohydr. Polym. 92(2), 1054-63, (2013)

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In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. Christensen, J.K., et al. J. Pharmacol. Exp. Ther. 309, 1003-1010, (2004)

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Identification of the toxic trigger in mushroom poisoning. Masanori Matsuura et al Nat. Chem. Biol. 5, 465-7, (2009)

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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Gregory Kaler et al J. Biol. Chem. 282, 23841-53, (2007)

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Wheat flour based propionic acid fermentation: an economic approach. Kagliwal LD, Survase SA, Singhal RS, et al. Bioresour. Technol. 129, 694-9, (2013)

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Response kinetics in the complex chemotaxis signalling pathway of Rhodobacter sphaeroides. Kojadinovic M, Armitage JP, Tindall MJ, et al. J. R. Soc. Interface 10(81), 20121001, (2013)

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Propionic acid and the phenomenon of rodent forestomach tumorigenesis: a review. Harrison PT Food Chem. Toxicol. 30(4), 333-40, (1992)

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Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei. Alekseev OM, Widgren EE, Richardson RT, et al. J. Biol. Chem. 280(4), 2904-11, (2005)

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Effect of dietary calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1. Bintvihok A and Kositcharoenkul S Toxicon 47(1), 41-6, (2006)

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MS/MS of synthetic peptide is not sufficient to confirm new types of protein modifications. Lee S, Tan M, Dai L, et al. J. Proteome Res. 12(2), 1007-13, (2013)

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The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators. Wang, Y., et al. Bioorg. Med. Chem. Lett. 20, 493-498, (2010)

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Metabolism of lactic acid in fermented cucumbers by Lactobacillus buchneri and related species, potential spoilage organisms in reduced salt fermentations. Johanningsmeier SD and McFeeters RF Food Microbiol. 35(2), 129-35, (2013)

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Characterization of cucumber fermentation spoilage bacteria by enrichment culture and 16S rDNA cloning. Breidt F, Medina E, Wafa D, et al. J. Food Sci. 78(3), M470-6, (2013)

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Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1. Marala RB, Brown JA, Kong JX, et al. Eur. J. Pharmacol. 451(1), 37-41, (2002)

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High catalytic activity of silicalite in gas-phase ketonisation of propionic acid. Bayahia H, Kozhevnikova E, and Kozhevnikov I Chem. Commun. (Camb.) 49(37), 3842-4, (2013)

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Chromium supplementation alters both glucose and lipid metabolism in feedlot cattle during the receiving period. Bernhard BC, Burdick NC, Rathmann RJ, et al. J. Anim. Sci. 90(13), 4857-65, (2012)

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Glucose is a pH-dependent motor for sperm beat frequency during early activation. Mannowetz N, Wandernoth PM, and Wennemuth G PLoS ONE 7(7), e41030, (2012)

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Methanol-driven enhanced biological phosphorus removal with a syntrophic consortium. Tayà C, Guerrero J, Vanneste G, et al. Biotechnol. Bioeng. 110(2), 391-400, (2013)

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High-throughput fluorescence screening of antioxidative capacity in human serum. Mayer B, Schumacher M, Brandstätter H, et al. Anal. Biochem. 297(2), 144-53, (2001)

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Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Maruo S, Kuriyama I, et al Bioorg. Med. Chem. 19, 5803-5812, (2011)

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Microstructure characterization of a food-grade U-type microemulsion system by differential scanning calorimetry and electrical conductivity techniques. Zhang H, Taxipalati M, Que F, et al. Food Chem. 141(3), 3050-5, (2013)

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Determination of drug-polymer binding constants by affinity capillary electrophoresis for aryl propionic acid derivatives and related compounds. Jia Z, Choi DS, and Chokshi H J. Pharm. Sci. 102(3), 960-6, (2013)

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Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Chandler RJ, Aswani V, Tsai MS, et al. Mol. Genet. Metab. 89(1-2), 64-73, (2006)

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Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups. Mendoza MF, Hollabaugh NM, Hettiarachchi SU, et al. Biochemistry 51(40), 8014-26, (2012)

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Burdock fermented by Aspergillus awamori elevates cecal Bifidobacterium, and reduces fecal deoxycholic acid and adipose tissue weight in rats fed a high-fat diet. Okazaki Y, Sitanggang NV, Sato S, et al. Biosci. Biotechnol. Biochem. 77(1), 53-7, (2013)

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Contribution of odd-numbered fatty acid oxidation to propionate production in neonates with methylmalonic and propionic acidaemias. Wendel U, Zass R, and Leupold D Eur. J. Pediatr. 152(12), 1021-3, (1993)

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Storage characteristics, nutritive value, energy content, and in vivo digestibility of moist, large rectangular bales of alfalfa-orchardgrass hay treated with a propionic acid-based preservative. Coblentz WK, Coffey KP, Young AN, et al. J. Dairy Sci. 96(4), 2521-35, (2013)

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In vitro degradation of lysine by ruminal fluid-based fermentations and by Fusobacterium necrophorum. Elwakeel EA, Amachawadi RG, Nour AM, et al. J. Dairy Sci. 96(1), 495-505, (2013)

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Hydrogen-bonded networks along and bifurcation of the E-pathway in quinol:fumarate reductase. Herzog E, Gu W, Juhnke HD, et al. Biophys. J. 103(6), 1305-14, (2012)

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Synthesis and antiradical/antioxidant activities of caffeic acid phenethyl ester and its related propionic, acetic, and benzoic acid analogues. LeBlanc LM, Paré AF, Jean-François J, et al. Molecules 17(12), 14637-50, (2012)

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Impact of thermal and organic acid treatment of feed on apparent ileal mineral absorption, tibial and liver mineral concentration, and tibia quality in broilers. Hafeez A, Mader A, Boroojeni FG, et al. Poult. Sci. 93(7), 1754-63, (2014)

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Effect of different concentrations of acetic, citric, and propionic acid dipping solutions on bacterial contamination of raw chicken skin. Menconi A, Shivaramaiah S, Huff GR, et al. Poult. Sci. 92(8), 2216-20, (2013)

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Development of a model system for the study of spoilage associated secondary cucumber fermentation during long-term storage. Franco W and Pérez-Díaz IM J. Food Sci. 77(10), M586-92, (2012)

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Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats. Król E, Krejpcio Z, Michalak S, et al. Biol. Trace Elem. Res. 150(1-3), 350-9, (2012)

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Growth inhibition of Erwinia amylovora and related Erwinia species by neutralized short‑chain fatty acids. Konecki K, Gernold M, Wensing A, et al. Arch. Microbiol. 195(10-11), 759-64, (2013)

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The many roles for fluorine in medicinal chemistry. William K Hagmann et al J. Med. Chem. 51, 4359-69, (2008)

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Merck 14,7825

Beil. 2,IV,695

Aldrich MSDS 1, 1545:C / Arctander, 2654 / Corp MSDS 1 (2), 2957:C / FT-IR 1 (1), 481:D / FT-IR 2 (1), 756:D / FT-NMR 1 (1), 751:C / Fenaroli / IR-Spectra (2), 256:C / IR-Spectra (3), 284:C / NMR-Reference 2 (1), 419:C / RegBook 1 (1), 533:G / RegBook 54 (1), 533:G / Sax 6, 2299 / Sigma FT-IR 1 (1), 1459:C / Structure Index 1, 75:D:2 / Vapor Phase 3, 573:D

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