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43107 Sigma-Aldrich

Cyanocobalamin

tested according to Ph.Eur.

Synonym: α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin, Vitamin B12

  • CAS Number 68-19-9

  • Empirical Formula (Hill Notation) C63H88CoN14O14P

  • Molecular Weight 1355.37

  •  Beilstein Registry Number 4122889

  •  EC Number 200-680-0

  •  MDL number MFCD00151092

  •  PubChem Substance ID 329756307

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Properties

Related Categories Biochemicals and Reagents, Core Bioreagents, Research Essentials, Vitamin B, Vitamin B12,
InChI Key   RMRCNWBMXRMIRW-QJRSUKKJSA-L
pharmacopeia   testing conforms to Pharmacopeia
solubility   water: soluble1 gm in 80 ml
  acetone: insoluble
  alcohol: soluble
  chloroform: insoluble
  diethyl ether: insoluble
storage temp.   2-8°C

Description

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Application

Cyanocobalamin was added in the assay buffer during the analysis step of ELISA for ensuring that all transcobalamin was saturated with cobalamin before analysis. Cyanocobalamin was also used for examining its impact on the expression of mPer1 and mPer2 in vivo.

Biochem/physiol Actions

Cyanocobalamin refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. Cyanocobalamin along with other B vitamins thiamine (B1) and pyridoxine (B6) blocks the thermal hyperalgesia in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ligation of the sciatic nerve (CCI). It can stimulate the anaerobic biodegradation of chloroform.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
GG3750000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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