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439223 Sigma-Aldrich

Dichloromethane

for HPLC, ≥99.9%, contains 40-150 ppm amylene as stabilizer

Synonym: Methylene chloride

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, Dichloromethane (Methylene chloride), HPLC Grade Solvents,
grade   for HPLC
vapor density   2.9 (vs air)
vapor pressure   24.45 psi ( 55 °C)
  6.83 psi ( 20 °C)
InChI Key   YMWUJEATGCHHMB-UHFFFAOYSA-N
assay   ≥99.9%
autoignition temp.   1223 °F
contains   40-150 ppm amylene as stabilizer
expl. lim.   22 %
impurities   Free halogens, passes test
  ≤0.0003 meq/g Titr. acid
  ≤0.02% water
evapn. residue   <0.0003%
color   APHA: ≤10
  clear
refractive index   n20/D 1.424(lit.)
bp   39.8-40 °C(lit.)
mp   −97 °C(lit.)
density   1.325 g/mL at 25 °C(lit.)
λ   H2O reference
UV absorption   λ: 235 nm Amax: 1.00
  λ: 240 nm Amax: 0.20
  λ: 250 nm Amax: 0.05
  λ: 260 nm Amax: 0.02
  λ: 340-400 nm Amax: 0.01
suitability   passes test for HPLC

Description

Packaging

4, 4×4 L in PVC-coated bottle

Preparation Note

Product filtered through a 0.2 μm filter

Application

Dichloromethane (Methylene chloride) may be used in the following processes:
• To compose ultrasonic baths for cleaning and protection of aluminum coating over atactic-PMMA (poly(methyl methacrylate)) for dielectric studies.
• Preparation of AMBF3 (ammoniomethyltrifluoroborate)-conjugated biomolecules.
• Sample preparation for GC-MS (Gas Chromatography-Mass Spectrometry) analysis.
• Preparation of ammonium acetate solvent mixture in combination with isopropanol, acetonitrile and water for mass spectral analysis of neutral lipids.
• Quantification of glutathione (GSH) and glutathione disulfide (GSSG) in biological samples by HPLC and spectrophotometry.
• As an extractant for 2,2-dithioethyl-4-(2′-pyridyl)-4-butyro-γ-lactone.

Meets ACS specifications

General description

Dichloromethane (DCM) is a chlorinated organic solvent with a wide range of industrial applications. It has C2v symmetry, low boiling point, high density and is immiscible in water. Degradation of DCM by various methods has been reported. Ultrasonic absorption studies of liquid DCM shows strong relaxation effect. A study reports the dielectric characteristics of DCM over a wide frequency range. DCM is susceptible to degradation with time, which can be suppressed by adding amylene as a stabilizer.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 1593 6.1 / PGIII
WGK Germany 
2
RTECS 
PA8050000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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