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45674 Sigma-Aldrich

Erythromycin

tested according to Ph.Eur.

Synonym: Erythromycinum

  • CAS Number 114-07-8

  • Empirical Formula (Hill Notation) C37H67NO13

  • Molecular Weight 733.93

  •  Beilstein Registry Number 75279

  •  EC Number 204-040-1

  •  MDL number MFCD00084654

  •  PubChem Substance ID 24869227

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Properties

Related Categories 1694 Pharmaceuticals & Personal Care Products, A - K, Additional Standards, Analytical Standards, Analytical/Chromatography,
InChI Key   ULGZDMOVFRHVEP-RWJQBGPGSA-N
pharmacopeia   testing conforms to Pharmacopeia
solubility   H2O: soluble2 mg/mL
  acetone: freely soluble
  acetonitrile: freely soluble
  alcohol: soluble
  amyl acetate: moderately soluble
  chloroform: soluble
  diethyl ether: soluble
  ethyl acetate: freely soluble
suitability   suitable for 1694 per US EPA
Mode of action   protein synthesis | interferes
Gene Information   human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
mouse ... Abcb1a(18671), Abcb1b(18669)

Description

Application

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Biochem/physiol Actions

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Caution

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
KF437500

Documents

Certificate of Analysis

Protocols & Articles

Articles

Inhibition of Protein Synthesis by Antibiotics

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere wi...
BioFiles 2006, 1.4, 17.
Keywords: Antibiotics, Environmental, Peptide synthesis

Peer-Reviewed Papers
15

References

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