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45706 Sigma-Aldrich

Warfarin

PESTANAL®, analytical standard

Synonym: 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin, Coumafene

  • CAS Number 81-81-2

  • Empirical Formula (Hill Notation) C19H16O4

  • Molecular Weight 308.33

  •  Beilstein Registry Number 8868198

  •  EC Number 201-377-6

  •  MDL number MFCD00006854

  •  PubChem Substance ID 329756915

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Properties

Related Categories Alpha Index of All Pesticide Standards, Analytical Standards, Analytical/Chromatography, Pesticides & Metabolites Standards, Q-Z,
grade   analytical standard
InChI Key   PJVWKTKQMONHTI-UHFFFAOYSA-N
product line   PESTANAL®
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   162-164 °C(lit.)
format   neat

Description

Caution

Restricted to professional users. Attention − Avoid exposure − obtain special instructions before use.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Warfarin is an anticoagulant commonly used in the prevention of thrombosis and thromboembolism. Its use is studied in stroke and pulmonary fibrosis patients among many others. It is used to study potential risks and interactions with other drugs and food.

Biochem/physiol Actions

Warfarin consists of a racemic mixture of two active enantiomers, R- and S- forms. Warfarin is slower-acting than the common anticoagulant heparin. Warfarin inhibits the vitamin K-dependent synthesis of biologically active forms of the calcium-dependent clotting factors II, VII, IX and X. It inhibits regulatory factors protein C, protein S, and protein Z.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
GN4550000
Protocols & Articles

Articles

HPLC Analysis of Warfarin™ Anticoagulant on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Anticoagulant on Ascentis® C18
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Anticoagulant on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Anticoagulant on Ascentis® RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 1)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 1)
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 2)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 2)
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V2
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CYCLOBOND® I 2000 (UV at 278 nm)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CYCLOBOND® I 2000 (UV at 278 nm)
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography

LC/MS (TOF) Analysis of Warfarin™ Enantiomers in Plasma on Astec® CHIROBIOTIC® V after SPE using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of Warfarin™ Enantiomers in Plasma on Astec® CHIROBIOTIC® V after SPE using HybridSPE®-Phospholipid
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solid phase extractions, Solvents

LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips
Keywords: Chromatography, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase microextractions

LC/MS/MS Analysis of Warfarin™ in Plasma on Ascentis® Express C18 after SPE using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Warfarin™ in Plasma on Ascentis® Express C18 after SPE using HybridSPE®-Phospholipid
Keywords: Anticoagulants, Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Reversed-phase chromatography, Solid phase extractions, Solvents

SFC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP, Ethanol Additive

From our library of Articles, Sigma-Aldrich presents SFC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP, Ethanol Additive
Keywords: Chromatography, Pharmaceutical, Supercritical fluid chromatography

SFC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP, Methanol Additive

From our library of Articles, Sigma-Aldrich presents SFC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP, Methanol Additive
Keywords: Chromatography, Clinical, Forensic, Supercritical fluid chromatography

SFC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP, Methanol Gradient

From our library of Articles, Sigma-Aldrich presents SFC Analysis of Warfarin™ Enantiomers on Astec® Cellulose DMP, Methanol Gradient
Keywords: Chromatography, Clinical, Forensic, Supercritical fluid chromatography

Peer-Reviewed Papers
15

References

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