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46401 Sigma-Aldrich

Cycloheximide

PESTANAL®, analytical standard

Synonym: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

  • CAS Number 66-81-9

  • Empirical Formula (Hill Notation) C15H23NO4

  • Molecular Weight 281.35

  •  Beilstein Registry Number 88868

  •  EC Number 200-636-0

  •  MDL number MFCD00082346

  •  PubChem Substance ID 329757163

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Properties

Related Categories Alpha Index of All Pesticide Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z,
grade   analytical standard
description   mixture of stereo isomers
InChI Key   YPHMISFOHDHNIV-FSZOTQKASA-N
product line   PESTANAL®
assay   ≥95% (HPLC)
form   neat
shelf life   limited shelf life, expiry date on the label
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
solubility   H2O: slightly soluble
Mode of action   protein synthesis | interferes
format   neat
storage temp.   2-8°C
Gene Information   human ... FKBP1A(2280), PIN1(5300)

Description

Biochem/physiol Actions

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
MA4375000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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