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481289 Sigma-Aldrich

Chlorosulfonic acid

reagent grade, ≥99%

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Properties

Related Categories Acids, Acids & Bases, Chemical Synthesis, Inorganic Acids, Synthetic Reagents More...
grade   reagent grade
vapor density   4 (vs air)
vapor pressure   1 mmHg ( 25 °C)
  3.3 mmHg ( 37.7 °C)
InChI Key   XTHPWXDJESJLNJ-UHFFFAOYSA-N
assay   ≥99%
expl. lim.   37.7 %
refractive index   n20/D 1.433(lit.)
bp   151-152 °C/755 mmHg(lit.)
solubility   acetic acid: soluble(lit.)
  chloroform: soluble(lit.)
  dichloromethane: soluble(lit.)
density   1.753 g/mL at 25 °C(lit.)

Description

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Gabriel Chemicals Product

Application

Chlorosulfonic acid may be used in the following processes:
• Synthesis of di-n-butyl ammonium chlorosulfonate, a secondary amine ionic liquid.
• To prepare sulfonated polyethersulfone (SPES) with enhanced hydrophilic property.
• To attach sulfate group to silk fibroin for improving its anticoagulant ability.
• As a catalyst to prepare substituted coumarin via von Pechmann condensation between phenol and β-ketoester.
• As a substitute to acid catalyst in Biginelli reaction to prepare 3,4-dihydropyrimidines.

General description

Chlorosulfonic acid is a strong acid that is synthesized on an industrial scale by reacting sulfur trioxide and dry hydrogen chloride gas in an equimolar ratio. It can act as a sulfonating, dehydrating, oxidizing and chlorinating agent. It is reported to be a better electrophilic olefin cyclization agent in comparison to other sulfonic acids. Its infrared spectra in the solid, liquid and gaseous state have been recorded in the region 4000-400cm-1.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
Reacts violently with water.
RIDADR 
UN 1754 8 / PGI
WGK Germany 
1
RTECS 
FX5730000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

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