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48710 Sigma-Aldrich

Propyl gallate

antioxidant, ≥98.0% (HPLC)

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester

  • CAS Number 121-79-9

  • Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3

  • Molecular Weight 212.20

  •  Beilstein Registry Number 1877976

  •  EC Number 204-498-2

  •  MDL number MFCD00002196

  •  PubChem Substance ID 329757396

  •  eCl@ss 39024506

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Building Blocks, C10 to C11, Carbonyl Compounds,
InChI Key   ZTHYODDOHIVTJV-UHFFFAOYSA-N
assay   ≥98.0% (HPLC)
mp   146-149 °C(lit.)
  146-149 °C

Description

Other Notes

Same product — same quality — now Sigma-Aldrich brand

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
LW8400000
Flash Point(F) 
368.6 °F
Flash Point(C) 
187 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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