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494496 Sigma-Aldrich

1-Methyl-2-pyrrolidinone

biotech. grade, ≥99.7%

Synonym: 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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Properties

Related Categories Amber Glass Bottles, Biotech, Biotech Solvents, Products, Returnable Containers,
grade   biotech. grade
  for peptide synthesis
vapor density   3.4 (vs air)
vapor pressure   0.29 mmHg ( 20 °C)
  0.99 mmHg ( 40 °C)
assay   ≥99.7%
autoignition temp.   518 °F
expl. lim.   9.5 %
impurities   ≤0.005% water
  ≤0.01% free amines (CH3NH2)
color   APHA: ≤20
refractive index   n20/D 1.47(lit.)
bp   202 °C(lit.)
  81-82 °C/10 mmHg(lit.)
mp   −24 °C(lit.)
density   1.028 g/mL at 25 °C(lit.)
λ   H2O reference
UV absorption   λ: 285 nm Amax: 1.00
  λ: 300 nm Amax: 0.50
  λ: 325 nm Amax: 0.10
  λ: 350-400 nm Amax: 0.01

Description

Packaging

1, 2, 4×2 L in Sure/Seal™

View returnable container options.

Price and Availability

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T
Risk Statements (Europe) 
Safety Statements (Europe) 
53-45
WGK Germany 
1
RTECS 
UY5790000
Flash Point(F) 
195.8 °F
Flash Point(C) 
91 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in N-Methyl-2-pyrrolidone (NMP) Using Karl Fischer Titration

Ketones have a tendency to form ketals. At the same time water is formed. The above mentioned compound belongs to the class of compounds which react sluggishly. Volumetric determination can be carrie...
Keywords: Exothermic, Titrations

Determination of Water Content in NMP (N-Methylpyrrolidone) Using Karl Fischer Titration

Ketones have a tendency to form ketals. At the same time water is formed. The above mentioned compound belongs to the class of compounds which react sluggishly. Volumetric determination can be carrie...
Keywords: Exothermic, Titrations

Peer-Reviewed Papers

References

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Phase separation micromolding: a new generic approach for microstructuring various materials. Vogelaar L, Lammertink RG, Barsema JN, et al. Small 1(6), 645-55, (2005)

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Determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in human urine. Jönsson BA and Akesson B J. Chromatogr. B. Biomed. Sci. Appl. 694(2), 351-7, (1997)

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Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery. Chun-Wa Chung et al J. Med. Chem. 55, 576-86, (2012)

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3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. David S Hewings et al J. Med. Chem. 54, 6761-70, (2011)

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Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer. Brodbeck KJ, DesNoyer JR, and McHugh AJ J. Control. Release 62(3), 333-44, (1999)

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Synthesis of insulin-like growth factor I using N-methyl pyrrolidinone as the coupling solvent and trifluoromethane sulphonic acid cleavage from the resin. Bagley CJ, Otteson KM, May BL, et al. Int. J. Pept. Protein Res. 36(4), 356-61, (1990)

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Noninvasive characterization of in situ forming implants using diagnostic ultrasound. Solorio L, Babin BM, Patel RB, et al. J. Control. Release 143(2), 183-90, (2010)

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Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica. Jih-Jung Chen et al J. Nat. Prod. 71, 1016-21, (2008)

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1-Methyl-2-pyrrolidinone (NMP) does not induce structural and numerical chromosomal aberrations in vivo. Engelhardt G and Fleig H Mutat. Res. 298(3), 149-55, (1993)

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Dermal exposure to aqueous solutions of N-methyl pyrrolidone. Akrill P, Cocker J, and Dixon S Toxicol. Lett. 134(1-3), 265-9, (2002)

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Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. Wesolowski D, et al. Proc. Natl. Acad. Sci. U. S. A. 108(40), 16582-7, (2011)

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Low-temperature synthesis of CuO-interlaced nanodiscs for lithium ion battery electrodes. Seung-Deok Seo et al Nanoscale Res. Lett. 6, 397, (2011)

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Transdermal absorption of radioprotectors using permeation-enhancing vehicles. Sodicoff M, Lamperti A, and Ziskin MC Radiat. Res. 121(2), 212-9, (1990)

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Examination of soil contaminated by coal-liquids by size exclusion chromatography in 1-methyl-2-pyrrolidinone solution to evaluate interference from humic and fulvic acids and extracts from peat. Morgan TJ, Herod AA, Brain SA, et al. J. Chromatogr. A 1095(1-2), 81-8, (2005)

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Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process. Payan JP, Beydon D, Fabry JP, et al. Drug Metab. Dispos. 30(12), 1418-24, (2002)

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Relevance of Frank's solvent classification as typically aqueous and typically non-aqueous to activities of firefly luciferase, alcohol dehydrogenase, and alpha-chymotrypsin in aqueous binaries. Fadnavis NW, Seshadri R, Sheelu G, et al. Arch. Biochem. Biophys. 433(2), 454-65, (2005)

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Control of EOF in CE by different ways of application of radial electric field. Sázelová P, Kasicka V, Koval D, et al. Electrophoresis 28(5), 756-66, (2007)

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The use of oxygen uptake rate to monitor discovery of microbial and enzymatic biocatalysts. Dumsday GJ, Ocal G, Bridger JS, et al. Biotechnol. Bioeng. 102(3), 673-83, (2009)

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Liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry determination of N-methylpyrrolidinone in riverine biofilms. Headley JV, Peru KM, Friesen DA, et al. J. Chromatogr. A 917(1-2), 159-65, (2001)

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Porosity and mechanically optimized PLGA based in situ hardening systems. Schloegl W, Marschall V, Witting MY, et al. Eur. J. Pharm. Biopharm. 82(3), 554-62, (2012)

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Partial dissolution of ACQ-treated wood in lithium chloride/N-methyl-2-pyrrolidinone: separation of copper from potential lignocellulosic feedstocks. Eberhardt TL, Lebow S, and Reed KG Chemosphere 86(8), 797-801, (2012)

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Wetting kinetics of modified polyimide surfaces: interactions with polar solvents. Thomas RR J. Colloid. Interface Sci. 279(2), 515-22, (2004)

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Delivery of atovaquone and proguanil across sublingual membranes, in vitro. Wallace E, Ong CM, and Heard CM Pharm. Dev. Technol. 17(6), 770-6, (2012)

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Estimation of the molecular mass range of the tar from pyrolysis of casein by gas chromatography-mass spectrometry, probe mass spectrometry and size exclusion chromatography with 1-methyl-2-pyrrolidinone as eluent. Purevsuren B, Avid B, Davaajav Y, et al. Eur. J. Mass Spectrom. (Chichester, Eng.) 10(1), 101-8, (2004)

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Development and pharmacokinetic evaluation of a curcumin co-solvent formulation. John MK, Xie H, Bell EC, et al. Anticancer Res. 33(10), 4285-91, (2013)

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Merck 14,6117

Beil. 21,V,6,321

Fieser 1,696 / Fieser 2,281 / Fieser 9,316

Aldrich MSDS 1, 1304:A / Corp MSDS 1 (2), 2433:A / FT-IR 2 (1), 1337:B / FT-IR 1 (1), 789:C / FT-NMR 1 (1), 1286:A / IR-Spectra (2), 415:G / IR-Spectra (3), 468:F / NMR-Reference 2 (1), 662:A / RegBook 1 (1), 923:E / Sax 6, 1924 / Sigma FT-IR 1 (2), 749:D / Structure Index 1, 143:C:4 / Vapor Phase 3, 788:D

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