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494496 Sigma-Aldrich

1-Methyl-2-pyrrolidinone

biotech. grade, ≥99.7%

Synonym: 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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Properties

Related Categories Amber Glass Bottles, Biotech, Biotech Solvents, Returnable Containers, Solvent Bottles,
grade   biotech. grade
  for peptide synthesis
vapor density   3.4 (vs air)
vapor pressure   0.29 mmHg ( 20 °C)
  0.99 mmHg ( 40 °C)
assay   ≥99.7%
autoignition temp.   518 °F
expl. lim.   9.5 %
impurities   ≤0.005% water
  ≤0.01% free amines (CH3NH2)
color   APHA: ≤20
refractive index   n20/D 1.47(lit.)
bp   202 °C(lit.)
  81-82 °C/10 mmHg(lit.)
mp   −24 °C(lit.)
solubility   acetone: miscible(lit.)
  alcohol: miscible(lit.)
  chloroform: miscible(lit.)
  ethyl acetate: miscible(lit.)
  water: miscible(lit.)
density   1.028 g/mL at 25 °C(lit.)
λ   H2O reference
UV absorption   λ: 285 nm Amax: 1.00
  λ: 300 nm Amax: 0.50
  λ: 325 nm Amax: 0.10
  λ: 350-400 nm Amax: 0.01

Description

Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

Packaging

1, 2, 4×2 L in Sure/Seal™

View returnable container options.

200 L in stainless steel drum

General description

N-Methyl-2-pyrrolidinone (N-methylpyrrolidone, NMP) is a polar cyclic organic solvent. A study on the impact of NMP on Saccharomyces cerevisiae revealed that it induced aneuploidy. Characteristic properties of NMP include low viscosity, excellent dissolving power and enhanced demulsifying property. It is a better alternative to phenol in selectively treating lube feedstock. The behavior of fullerene-C60 in NMP solution has been examined based on electronic absorption and photoluminescence spectral data. A solution of sodium borohydride (NaBH4) in NMP showed increased reactivity towards debromination of alkyl bromide. The enhanced selectivity of NMP-ethylene glycol solvent mixture for aromatic hydrocarbon extraction has been analyzed by gas chromatography.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
1
RTECS 
UY5790000
Flash Point(F) 
195.8 °F
Flash Point(C) 
91 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in N-Methyl-2-pyrrolidone (NMP) Using Karl Fischer Titration

Ketones have a tendency to form ketals. At the same time water is formed. The above mentioned compound belongs to the class of compounds which react sluggishly. Volumetric determination can be carrie...
Keywords: Exothermic, Titrations

Determination of Water Content in NMP (N-Methylpyrrolidone) Using Karl Fischer Titration

Ketones have a tendency to form ketals. At the same time water is formed. The above mentioned compound belongs to the class of compounds which react sluggishly. Volumetric determination can be carrie...
Keywords: Exothermic, Titrations

Peer-Reviewed Papers
15

References

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