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494496 Sigma-Aldrich

1-Methyl-2-pyrrolidinone

biotech. grade, ≥99.7%

Synonym: 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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Properties

Related Categories Amber Glass Bottles, Biotech, Biotech Solvents, Products, Returnable Containers,
grade   biotech. grade
  for peptide synthesis
vapor density   3.4 (vs air)
vapor pressure   0.29 mmHg ( 20 °C)
  0.99 mmHg ( 40 °C)
assay   ≥99.7%
autoignition temp.   518 °F
expl. lim.   9.5 %
impurities   ≤0.005% water
  ≤0.01% free amines (CH3NH2)
color   APHA: ≤20
refractive index   n20/D 1.47(lit.)
bp   202 °C(lit.)
  81-82 °C/10 mmHg(lit.)
mp   −24 °C(lit.)
density   1.028 g/mL at 25 °C(lit.)
λ   H2O reference
UV absorption   λ: 285 nm Amax: 1.00
  λ: 300 nm Amax: 0.50
  λ: 325 nm Amax: 0.10
  λ: 350-400 nm Amax: 0.01

Description

Other Notes

A -D suffix exists for administrative purposes only.
All -D packages are 100% the same product, same quality, same specification as the package sizes previously sold without a -D.

Packaging

1, 2, 4×2 L in Sure/Seal™

View returnable container options.

200 L in stainless steel drum

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
1
RTECS 
UY5790000
Flash Point(F) 
195.8 °F
Flash Point(C) 
91 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Determination of Water Content in N-Methyl-2-pyrrolidone (NMP) Using Karl Fischer Titration

Ketones have a tendency to form ketals. At the same time water is formed. The above mentioned compound belongs to the class of compounds which react sluggishly. Volumetric determination can be carrie...
Keywords: Exothermic, Titrations

Determination of Water Content in NMP (N-Methylpyrrolidone) Using Karl Fischer Titration

Ketones have a tendency to form ketals. At the same time water is formed. The above mentioned compound belongs to the class of compounds which react sluggishly. Volumetric determination can be carrie...
Keywords: Exothermic, Titrations

Peer-Reviewed Papers

References

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Solvothermal-assisted liquid-phase exfoliation of graphite in a mixed solvent of toluene and oleylamine. Dang DK, Kim EJ, et al. Nanoscale Res. Lett. 10(1), 727, (2015)

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Black phosphorus quantum dots. Zhang X, Xie H, Liu Z, et al. Angew. Chem. Int. Ed. Engl. 54(12), 3653-7, (2015)

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Plasmon resonances of highly doped two-dimensional MoS?. Wang Y, Ou JZ, Chrimes AF, et al. Nano Lett. 15(2), 883-90, (2015)

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Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Sato T, Goyama S, Kataoka K, et al. Oncogene 33(42), 5028-38, (2014)

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Inhibition of angiogenesis by antioxidant micelles. Moriyama M, Metzger S, van der Vlies AJ, et al. Adv. Healthc. Mater. 4(4), 569-75, (2015)

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Killing of Mycobacterium avium by lactoferricin peptides: improved activity of arginine- and D-amino-acid-containing molecules. Silva T, Magalhães B, Maia S, et al. Antimicrob. Agents Chemother. 58(6), 3461-7, (2014)

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Influence of heat curing on structure and physicochemical properties of phenolic acid loaded proteinaceous electrospun fibers. Neo YP, Perera CO, Nieuwoudt MK, et al. J. Agric. Food Chem. 62(22), 5163-72, (2014)

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Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia. Jagtap AD, Chang PT, Liu JR, et al. Eur. J. Med. Chem. 85, 268-88, (2014)

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Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor. Wang HC, Jagtap AD, Chang PT, et al. Eur. J. Med. Chem. 84, 312-34, (2014)

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Reinforced carbon nanotubes as electrically conducting and flexible films for space applications. Atar N, Grossman E, Gouzman I, et al. ACS Appl. Mater. Interfaces 6(22), 20400-7, (2014)

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Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Alagesan B, Contino G, Guimaraes AR, et al. Clin. Cancer Res. 21(2), 396-404, (2015)

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Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors. Hassan B, Akcakanat A, Sangai T, et al. Oncotarget 5(18), 8544-57, (2014)

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Molecular engineering of manipulated alginate-based polyurethanes. Daemi H, Barikani M, et al. Carbohydr. Polym. 112, 638-47, (2014)

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Correlation of length of linear oligo(ethanamino) amides with gene transfer and cytotoxicity. Scholz C, Kos P, Leclercq L, et al. ChemMedChem 9(9), 2104-10, (2014)

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Micro-nanostructured CuO/C spheres as high-performance anode materials for Na-ion batteries. Lu Y, Zhang N, Zhao Q, et al. Nanoscale 7(6), 2770-6, (2015)

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In situ forming implants for periodontitis treatment with improved adhesive properties. Do MP, Neut C, Delcourt E, et al. Eur. J. Pharm. Biopharm. 88(2), 342-50, (2014)

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Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles. Vela-Ramirez JE, Goodman JT, Boggiatto PM, et al. AAPS J. 17(1), 256-67, (2015)

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Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes. Hoppes R, Oostvogels R, Luimstra JJ, et al. J. Immunol. 193(10), 4803-13, (2014)

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Enhanced oral delivery of curcumin from N-trimethyl chitosan surface-modified solid lipid nanoparticles: pharmacokinetic and brain distribution evaluations. Ramalingam P, Ko YT, et al. Pharm. Res. 32(2), 389-402, (2015)

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Challenges of going nano: enhanced electrochemical performance of cobalt oxide nanoparticles by carbothermal reduction and in situ carbon coating. Bresser D, Paillard E, Niehoff P, et al. ChemPhysChem 15(10), 2177-85, (2014)

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Li(1.2)Mn(0.6)Ni(0.1)Co(0.1)O2 microspheres constructed by hierarchically arranged nanoparticles as lithium battery cathode with enhanced electrochemical performance. Remith P, Kalaiselvi N, et al. Nanoscale 6(24), 14724-32, (2014)

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Sepsis attenuates the anabolic response to skeletal muscle contraction. Steiner JL, Lang CH, et al. Shock 43(4), 344-51, (2015)

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Asenapine maleate in situ forming biodegradable implant: an approach to enhance bioavailability. Avachat AM, Kapure SS, et al. Int. J. Pharm. 477(1-2), 64-72, (2014)

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Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. Tong Q, Qing Y, Wu Y, et al. Toxicol. Appl. Pharmacol. 281(2), 166-73, (2014)

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The influence of linker length on the properties of cathepsin S cleavable (177)Lu-labeled HPMA copolymers for pancreatic cancer imaging. Shi W, Ogbomo SM, Wagh NK, et al. Biomaterials 35(22), 5760-70, (2014)

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The synergistic effect of ultrasound and chemical penetration enhancers on chorioamnion mass transport. Azagury A, Khoury L, Adato Y, et al. J. Control. Release 200, 35-41, (2015)

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Ultrasmall Li2S nanoparticles anchored in graphene nanosheets for high-energy lithium-ion batteries. Zhang K, Wang L, Hu Z, et al. Sci. Rep. 4, 6467, (2014)

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In-situ forming gel-like depot of a polyaspartamide-polylactide copolymer for once a week administration of sulpiride. Fiorica C, Palumbo FS, Pitarresi G, et al. J. Pharm. Pharmacol. 67(1), 78-86, (2014)

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Synthesis of antifungal vaccines by conjugation of ?-1,2 trimannosides with T-cell peptides and covalent anchoring of neoglycopeptide to tetanus toxoid. Cartmell J, Paszkiewicz E, Dziadek S, et al. Carbohydr. Res. 403, 123-34, (2015)

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Mass Spectrometric Immunoassay for the qualitative and quantitative analysis of the cytokine Macrophage Migration Inhibitory Factor (MIF). Sherma ND, Borges CR, Trenchevska O, et al. Proteome Sci. 12(1), 52, (2014)

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Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function. Pierdominici M, Maselli A, Cecchetti S, et al. Part. Fibre Toxicol. 11, 74, (2015)

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Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy. Moding EJ, Castle KD, Perez BA, et al. Sci. Transl. Med. 7(278), 278ra34, (2015)

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Red phosphorus-single-walled carbon nanotube composite as a superior anode for sodium ion batteries. Zhu Y, Wen Y, Fan X, et al. ACS Nano 9(3), 3254-64, (2015)

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Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides. Li Y, San BH, Kessler JL, et al. Macromol. Biosci. 15(1), 52-62, (2015)

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Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia. Sandhöfer N, Metzeler KH, Rothenberg M, et al. Leukemia 29(4), 828-38, (2015)

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Liquid-phase exfoliated graphene as highly-sensitive sensor for simultaneous determination of endocrine disruptors: diethylstilbestrol and estradiol. Hu L, Cheng Q, Chen D, et al. J. Hazard. Mater. 283, 157-63, (2014)

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Ternary metal fluorides as high-energy cathodes with low cycling hysteresis. Wang F, Kim SW, Seo DH, et al. Nat. Commun. 6, 6668, (2015)

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A de novo designed 2[4Fe-4S] ferredoxin mimic mediates electron transfer. Roy A, Sommer DJ, Schmitz RA, et al. J. Am. Chem. Soc. 136(49), 17343-9, (2014)

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A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis. Burrell-Saward H, Rodgers J, Bradley B, et al. J. Antimicrob. Chemother. 70(2), 510-7, (2015)

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Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids. Zhao C, Hoppe T, Setty MK, et al. Nat. Commun. 5, 5079, (2014)

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Enhancing photoinduced electron transfer efficiency of fluorescent pH-probes with halogenated phenols. Aigner D, Freunberger SA, Wilkening M, et al. Anal. Chem. 86(18), 9293-300, (2014)

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Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies. Neveu C, Dulin F, Lefranc B, et al. Br. J. Pharmacol. 171(19), 4425-39, (2014)

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Effect of selective heparin desulfation on preservation of bone morphogenetic protein-2 bioactivity after thermal stress. Seto SP, Miller T, Temenoff JS, et al. Bioconjug. Chem. 26(2), 286-93, (2015)

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Serum amyloid a truncations in type 2 diabetes mellitus. Yassine HN, Trenchevska O, He H, et al. PLoS ONE 10(1), e0115320, (2015)

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Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity. Ross KA, Loyd H, Wu W, et al. Int. J. Nanomedicine 10, 229-43, (2015)

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Delineation of concentration ranges and longitudinal changes of human plasma protein variants. Trenchevska O, Phillips DA, Nelson RW, et al. PLoS ONE 9(6), e100713, (2014)

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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects. Bonaventure P, Yun S, Johnson PL, et al. J. Pharmacol. Exp. Ther. 352(3), 590-601, (2015)

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A monolithic drug-in-adhesive patch of methoxyflavones from Kaempferia parviflora: in vitro and in vivo evaluation. Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, et al. Int. J. Pharm. 478(2), 486-95, (2015)

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In vitro efficacy of polysaccharide-based nanoparticles containing disease-modifying antirheumatic drugs. Zhang N, Wardwell PR, Bader RA, et al. Pharm. Res. 31(9), 2326-34, (2014)

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Quantitative mass spectrometric immunoassay for the chemokine RANTES and its variants. Trenchevska O, Sherma ND, Oran PE, et al. J. Proteomics 116, 15-23, (2015)

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Merck 14,6117

Beil. 21,V,6,321

Fieser 1,696 / Fieser 2,281 / Fieser 9,316

Aldrich MSDS 1, 1304:A / Corp MSDS 1 (2), 2433:A / FT-IR 2 (1), 1337:B / FT-IR 1 (1), 789:C / FT-NMR 1 (1), 1286:A / IR-Spectra (2), 415:G / IR-Spectra (3), 468:F / NMR-Reference 2 (1), 662:A / RegBook 1 (1), 923:E / Sax 6, 1924 / Sigma FT-IR 1 (2), 749:D / Structure Index 1, 143:C:4 / Vapor Phase 3, 788:D

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