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52512 Sigma-Aldrich

1,1,1,3,3,3-Hexafluoro-2-propanol

puriss., ≥99.0% (GC)

Synonym: HFP, Hexafluoroisopropanol

  • CAS Number 920-66-1

  • Linear Formula (CF3)2CHOH

  • Molecular Weight 168.04

  •  Beilstein Registry Number 1841007

  •  EC Number 213-059-4

  •  MDL number MFCD00011651

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Properties

Related Categories Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Organic Building Blocks,
grade   puriss.
assay   ≥99.0% (GC)
impurities   ≤0.1% water
refractive index   n20/D 1.275(lit.)
bp   59 °C(lit.)
mp   −4 °C(lit.)
density   1.596 g/mL at 25 °C(lit.)

Description

Other Notes

Solvent with high solubilizing potential for peptides and peptide intermediates1

This product has been replaced by 105228-ALDRICH | 1,1,1,3,3,3-Hexafluoro-2-propanol ≥99%

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2922 6.1(8) / PGII
WGK Germany 
2
RTECS 
UB6450000
Protocols & Articles
Peer-Reviewed Papers

References

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Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice. Yanagisawa D, Ibrahim NF, Taguchi H, et al. Neurobiol. Aging 36(1), 201-10, (2014)

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Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function. Mastroeni D, Khdour OM, Arce PM, et al. ACS Chem. Neurosci. 6(4), 588-98, (2015)

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Semi-interpenetrating network (sIPN) co-electrospun gelatin/insulin fiber formulation for transbuccal insulin delivery. Xu L, Sheybani N, Ren S, et al. Pharm. Res. 32(1), 275-85, (2015)

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Toll-like receptor 2 and NLRP3 cooperate to recognize a functional bacterial amyloid, curli. Rapsinski GJ, Wynosky-Dolfi MA, Oppong GO, et al. Infect. Immun. 83(2), 693-701, (2015)

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Cytotoxic and mutagenic properties of regioisomeric O²-, N3- and O?-ethylthymidines in bacterial cells. Zhai Q, Wang P, Wang Y, et al. Carcinogenesis 35(9), 2002-6, (2014)

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Phosphorylation regulates fibrillation of an aggregation core peptide in the second repeat of microtubule-binding domain of human tau. Inoue M, Kaida S, Nakano S, et al. Bioorg. Med. Chem. 22(22), 6471-80, (2015)

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Systematic evaluation of mobile phase additives for the LC-MS characterization of therapeutic proteins. Bobály B, Beck A, Fekete J, et al. Talanta 136, 60-7, (2015)

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Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration. Todd K, Fossati S, Ghiso J, et al. Biochim. Biophys. Acta 1842(12 Pt A), 2457-67, (2014)

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Effective immobilization of BMP-2 mediated by polydopamine coating on biodegradable nanofibers for enhanced in vivo bone formation. Cho HJ, Perikamana SK, Lee JH, et al. ACS Appl. Mater. Interfaces 6(14), 11225-35, (2014)

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PLGA nanofiber membranes loaded with epigallocatechin-3-O-gallate are beneficial to prevention of postsurgical adhesions. Shin YC, Yang WJ, Lee JH, et al. Int. J. Nanomedicine 9, 4067-78, (2014)

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Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family. Zallot R, Brochier-Armanet C, Gaston KW, et al. ACS Chem. Biol. 9(8), 1812-25, (2014)

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Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions. Susa AC, Wu C, Bernstein SL, et al. J. Am. Chem. Soc. 136(37), 12912-9, (2014)

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Effects of secondary metabolite extract from Phomopsis occulta on β-amyloid aggregation. Wu H, Zhang F, Williamson N, et al. PLoS ONE 9(10), e109438, (2014)

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Cardiolipin-incorporated liposomes with surface CRM197 for enhancing neuronal survival against neurotoxicity. Kuo YC, Liu YC, et al. Int. J. Pharm. 473(1-2), 334-44, (2014)

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Plasma membrane injury depends on bilayer lipid composition in Alzheimer's disease. Evangelisti E, Zampagni M, Cascella R, et al. J. Alzheimers Dis. 41(1), 289-300, (2014)

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Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits. Hou Y, Wang Y, Zhao J, et al. PLoS ONE 9(11), e111215, (2014)

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A comparative study on in vitro osteogenic priming potential of electron spun scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for tissue engineering application. Balaji Raghavendran HR, Puvaneswary S, Talebian S, et al. PLoS ONE 9(8), e104389, (2014)

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Role of the coiled-coil structural motif in polyglutamine aggregation. Kokona B, Rosenthal ZP, Fairman R, et al. Biochemistry 53(43), 6738-46, (2014)

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Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning. Chen MH, Liang PC, Chang KC, et al. Biomed. Eng. Online 13, 118, (2014)

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In vivo evaluation of electrospun polycaprolactone graft for anterior cruciate ligament engineering. Petrigliano FA, Arom GA, Nazemi AN, et al. Tissue Eng. Part A 21(7-8), 1228-36, (2015)

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Cauda equina-derived extracellular matrix for fabrication of nanostructured hybrid scaffolds applied to neural tissue engineering. Wen X, Wang Y, Guo Z, et al. Tissue Eng. Part A 21(5-6), 1095-105, (2015)

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Osseointegrative properties of electrospun hydroxyapatite-containing nanofibrous chitosan scaffolds. Frohbergh ME, Katsman A, Mondrinos MJ, et al. Tissue Eng. Part A 21(5-6), 970-81, (2015)

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Effect of brain-derived neurotrophic factor on mesenchymal stem cell-seeded electrospinning biomaterial for treating ischemic diabetic ulcers via milieu-dependent differentiation mechanism. He S, Shen L, Wu Y, et al. Tissue Eng. Part A 21(5-6), 928-38, (2015)

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Combination of aligned PLGA/Gelatin electrospun sheets, native dental pulp extracellular matrix and treated dentin matrix as substrates for tooth root regeneration. Chen G, Chen J, Yang B, et al. Biomaterials 52, 56-70, (2015)

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Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids. Benchekroun M, Bartolini M, Egea J, et al. ChemMedChem 10(3), 523-39, (2015)

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Retinal ganglion cell polarization using immobilized guidance cues on a tissue-engineered scaffold. Kador KE, Alsehli HS, Zindell AN, et al. Acta Biomater. 10(12), 4939-46, (2014)

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Electrogenerated chemiluminescence behavior of peptide nanovesicle and its application in sensing dopamine. Huang C, Chen X, Lu Y, et al. Biosens. Bioelectron. 63, 478-82, (2014)

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Alternative eluent composition for LC-MS analysis of perfluoroalkyl acids in raw fish samples. Haljasorg T, Saame J, Kipper K, et al. J. Agric. Food Chem. 62(23), 5259-68, (2014)

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Highly flexible and rapidly degradable papaverine-loaded electrospun fibrous membranes for preventing vasospasm and repairing vascular tissue. Zhu W, Liu S, Zhao J, et al. Acta Biomater. 10(7), 3018-28, (2014)

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Development of amino acid derivatization reagents for liquid chromatography electrospray ionization mass spectrometric analysis and ionization efficiency measurements. Rebane R, Rodima T, Kütt A, et al. J. Chromatogr. A. 1390, 62-70, (2015)

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Biodegradable vancomycin-eluting poly[(d,l)-lactide-co-glycolide] nanofibres for the treatment of postoperative central nervous system infection. Tseng YY, Wang YC, Su CH, et al. Sci. Rep. 5, 7849, (2015)

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Biomonitoring occupational sevoflurane exposure at low levels by urinary sevoflurane and hexafluoroisopropanol. Scapellato ML, Carrieri M, Maccà I, et al. Toxicol. Lett. 231(2), 154-60, (2014)

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Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes. Pluci?ska K, Crouch B, Koss D, et al. J. Neurosci. 34(32), 10710-28, (2014)

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Robust fabrication of electrospun-like polymer mats to direct cell behaviour. Ballester-Beltrán J, Lebourg M, Capella H, et al. Biofabrication 6(3), 035009, (2014)

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Neuroprotective effect of Chunghyuldan from amyloid beta oligomer induced neuroinflammation in vitro and in vivo. Kim HG, Kim JY, Whang WW, et al. Can. J. Physiol. Pharmacol. 92(6), 429-37, (2014)

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Biodegradable drug-eluting nanofiber-enveloped implants for sustained release of high bactericidal concentrations of vancomycin and ceftazidime: in vitro and in vivo studies. Hsu YH, Chen DW, Tai CD, et al. Int. J. Nanomedicine 9, 4347-55, (2014)

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Promoting endothelial recovery and reducing neointimal hyperplasia using sequential-like release of acetylsalicylic acid and paclitaxel-loaded biodegradable stents. Lee CH, Yu CY, Chang SH, et al. Int. J. Nanomedicine 9, 4117-33, (2014)

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Hexafluoroisopropanol-induced coacervation in aqueous mixed systems of cationic and anionic surfactants for the extraction of sulfonamides in water samples. Chen D, Zhang P, Li Y, et al. Anal. Bioanal. Chem, (2014)

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Amyloid beta-mediated epigenetic alteration of insulin-like growth factor binding protein 3 controls cell survival in Alzheimer's disease. Sung HY, Choi EN, Lyu D, et al. PLoS ONE 9(6), e99047, (2014)

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Aldrich MSDS 1, 1023:C / Corp MSDS 1 (1), 1847:C / FT-IR 1 (1), 179:A / FT-IR 2 (1), 259:A / FT-NMR 1 (1), 279:C / IR-Spectra (2), 102:D / IR-Spectra (3), 110:D / NMR-Reference 2 (1), 167:B / RegBook 1 (1), 181:D / Sax 6, 1513 / Sigma FT-IR 1 (1), 1341:C / Structure Index 1, 24:C:2 / Vapor Phase 3, 259:D

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