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52619 Sigma-Aldrich

Hexamethyldisilazane

for GC derivatization, ≥99.0% (GC)

Synonym: HMDS

  • CAS Number 999-97-3

  • Linear Formula (CH3)3SiNHSi(CH3)3

  • Molecular Weight 161.39

  •  Beilstein Registry Number 635752

  •  EC Number 213-668-5

  •  MDL number MFCD00008259

  •  PubChem Substance ID 24874541

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC,
grade   for GC derivatization
InChI Key   FFUAGWLWBBFQJT-UHFFFAOYSA-N
assay   ≥99.0% (GC)
refractive index   n20/D 1.407(lit.)
  n20/D 1.408
bp   125 °C(lit.)
derivatization reagent for   Silylations

Description

Application

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Other Notes

Important silylating agent

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Same product — same quality — now Sigma-Aldrich brand

Price and Availability


Tools for Small Molecule BioAnalysis
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 1992 6.1(3) / PGII
WGK Germany 
2
RTECS 
JM9230000
Flash Point(F) 
51.8 °F
Flash Point(C) 
11 °C
Protocols & Articles

Articles

Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs

Human and veterinary pharmaceuticals are a group of “emerging” contaminants,1, 2 some of which are produced in increasingly large volumes every year. The amounts produced are reaching quantities simi...
Luis-Alberto Martin
AnalytiX Volume 10 Article 2
Keywords: Anti-inflammatory agents, Derivatizations, Environmental, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Metabolites, Pesticides, Pharmaceutical, Silylations, Veterinary

Peer-Reviewed Papers
15

References

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