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53289 Sigma-Aldrich

[Tyr63]Hirudin (HV1), leech recombinant from yeast

≥95% (HPLC), ~500 U/mg

Synonym: Desulfato-hirudin, Desulfo-hirudin, [63-Tyrosine]Hirudin (HV1), leech

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Proteins More...
assay   ≥90% protein basis
  ≥95% (HPLC)
impurities   ≤0.05 units/mg endotoxins (LAL test)
  ≤10% water
storage temp.   −70°C

Description

Other Notes

The most potent, specific inhibitor of thrombin; Characterization of recombinant desulfo hirudin; Pharmacological survey of recombinant hirudin

Unit Definition

1 U corresponds to the amount of inhibitor which reduces the thrombin activity by 1 U at pH 7.5 and 37°C, Tos-Gly-Pro-Arg-4NA.AcOH (=Chromozym® TH) as substrate

Legal Information

Chromozym is a registered trademark of Pentapharm AG, Basel

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MR8440000

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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