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59740 Sigma-Aldrich

Isopropyl β-D-1-thiogalactopyranoside

≥99.0% (TLC)

Synonym: IPTG, Isopropyl β-D-thiogalactoside

  • CAS Number 367-93-1

  • Empirical Formula (Hill Notation) C9H18O5S

  • Molecular Weight 238.30

  •  Beilstein Registry Number 4631

  •  EC Number 206-703-0

  •  MDL number MFCD00063273

  •  PubChem Substance ID 24881691

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Properties

Related Categories Biochemicals and Reagents, Detergents, Detergents A to M, Detergents by Applications, Membrane Protein Solubilization,
description   non-ionic
InChI Key   BPHPUYQFMNQIOC-NXRLNHOXSA-N
assay   ≥99.0% (TLC)
optical activity   [α]20/D −32.0±1.0°, c = 1% in H2O (dry matter)
ign. residue   ≤0.2%
loss   ≤6% loss on drying
storage temp.   −20°C

Description

Application

IPTG is commonly used in cloning procedures that require induction of β-galactosidase activity. It is used in conjunction with X-Gal or Bluo-Gal in blue-white selection of recombinant bacterial colonies that induce expression of the lac operon in Escherichia coli. IPTG functions by binding to the lacI repressor and altering its conformation, which prevents the repression of the β-galactosidase coding gene lacZ.

Other Notes

Non-metabolizable galactose analog.

IPTG is an inducer of β-galactosidase activity in bacteria and is used to detect lac gene activity during cloning experiments

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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I5502 Isopropyl β-D-1-thiogalactopyranoside, ≥99% (TLC)

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