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61767 Sigma-Aldrich

Lectin from Triticum vulgaris

lyophilized, ≥55% (GE), powder

Synonym: WGA, Wheat germ agglutinin

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Properties

assay   ≥55% (GE)
form   powder
quality   lyophilized
suitability   corresponds for agglutination (with fresh human erythrocytes)
storage temp.   2-8°C

Description

General description

WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.

Other Notes

Molecular characteristics and specificity for sugar binding

Application

Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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