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63013 Sigma-Aldrich

α2-Macroglobulin from human plasma

≥90% (GE)

Synonym: α2-M

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Properties

Related Categories α2-Macroglobulin, Biochemicals and Reagents, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteins and Derivatives More...
assay   ≥90% (GE)
mol wt   mol wt ~720 kDa (four glycoprotein subunits)
solubility   H2O: soluble1 mg/mL, clear to faintly turbid, colorless to faintly yellow
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... A2M(2)

Description

Analysis Note

100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0

Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

Application

Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.

Other Notes

Conformational changes of α2-M

Biochem/physiol Actions

α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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