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63175 Sigma-Aldrich

4-Maleimidobutyric acid N-hydroxysuccinimide ester

≥98.0% (HPLC)

Synonym: 4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-Maleimidobutyryloxy)succinimide, N-Succinimidyl 4-maleimidobutyrate, GMBS

  • CAS Number 80307-12-6

  • Empirical Formula (Hill Notation) C12H12N2O6

  • Molecular Weight 280.23

  •  Beilstein Registry Number 6427689

  •  MDL number MFCD00036817

  •  PubChem Substance ID 329759802

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Properties

Related Categories Amine to Sulfhydryl, Chemical Biology, Chemical Synthesis, Crosslinkers, Linkers and Crosslinkers More...
InChI Key   PVGATNRYUYNBHO-UHFFFAOYSA-N
assay   ≥98.0% (HPLC)
mp   123-129 °C
storage temp.   2-8°C

Description

Application

A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 7-atom linker.

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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