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  • 63177 - 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

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63177 Sigma-Aldrich

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

≥98.0% (HPLC)

Synonym: 6-Maleimidocaproic acid N-succinimidyl ester, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidocaproate, EMCS

  • CAS Number 55750-63-5

  • Empirical Formula (Hill Notation) C14H16N2O6

  • Molecular Weight 308.29

  •  Beilstein Registry Number 1499815

  •  MDL number MFCD00043043

  •  PubChem Substance ID 329759804

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Properties

Related Categories Amine to Sulfhydryl, Chemical Biology, Chemical Synthesis, Crosslinkers, Linkers and Crosslinkers More...
InChI Key   VLARLSIGSPVYHX-UHFFFAOYSA-N
assay   ≥98.0% (HPLC)
mp   67-73 °C
  70-73 °C(lit.)
storage temp.   −20°C

Description

Other Notes

Reagent for cross-linking and immobilisation of proteins

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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