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64682 Sigma-Aldrich

Pyrroloquinoline quinone

≥97.0% (HPLC)

Synonym: 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ

  • CAS Number 72909-34-3

  • Empirical Formula (Hill Notation) C14H6N2O8

  • Molecular Weight 330.21

  •  Beilstein Registry Number 3596812

  •  MDL number MFCD00043125

  •  PubChem Substance ID 329759991

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Properties

Related Categories Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Oxidation-Reduction
InChI Key   MMXZSJMASHPLLR-UHFFFAOYSA-N
assay   ≥97.0% (HPLC)
impurities   ≤15% water
storage temp.   2-8°C

Description

Biochem/physiol Actions

PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture. It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.

General description

Novel o-quinone coenzyme found in bacterial dehydrogenases and oxidases.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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D7783 Pyrroloquinoline quinone, ≥95.0% (HPLC)

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