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65361 Sigma-Aldrich

(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid

for chiral derivatization, ≥99.0%

Synonym: (+)-MTPA, Mosher’s acid

  • CAS Number 20445-31-2

  • Linear Formula C6H5C(OCH3)(CF3)CO2H

  • Molecular Weight 234.17

  •  Beilstein Registry Number 3591560

  •  EC Number 243-829-5

  •  MDL number MFCD00004184

  •  PubChem Substance ID 329760051

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chiral, Chiral Derivatization Reagents, Chiral GC Derivatization Reagents,
grade   for chiral derivatization
InChI Key   JJYKJUXBWFATTE-SECBINFHSA-N
assay   ≥99.0% (T)
  ≥99.0%
optical activity   [α]20/D +73±1°, c = 2% in methanol
optical purity   enantiomeric ratio: ≥99.5:0.5 (GC)
refractive index   n20/D 1.473(lit.)
bp   105-107 °C/1 mmHg(lit.)
mp   46-49 °C(lit.)
density   1.344 g/mL at 25 °C(lit.)
storage temp.   2-8°C

Description

Other Notes

Reagent for enantiomeric alcohols, (+)-a-methoxy-a-trifluoromethylphenyleacetyl, and (+)-a-methoxy-a-trifluoromethylphenyleacetamide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Reagent used for the determination of the enantiomeric purity and the absolute configuration of alcohols and amines by NMR; doi:10.1038/nprot.2007.354; Review

General description

Mosher’s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

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Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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