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65361 Sigma-Aldrich

(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid

for chiral derivatization, ≥99.0%

Synonym: (+)-MTPA, Mosher’s acid

  • CAS Number 20445-31-2

  • Linear Formula C6H5C(OCH3)(CF3)CO2H

  • Molecular Weight 234.17

  •  Beilstein Registry Number 3591560

  •  EC Number 243-829-5

  •  MDL number MFCD00004184

  •  PubChem Substance ID 329760051

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chiral, Chiral Derivatization Reagents, Chiral GC Derivatization Reagents,
grade   for chiral derivatization
InChI Key   JJYKJUXBWFATTE-SECBINFHSA-N
assay   ≥99.0% (T)
  ≥99.0%
optical activity   [α]20/D +73±1°, c = 2% in methanol
optical purity   enantiomeric ratio: ≥99.5:0.5 (GC)
refractive index   n20/D 1.473(lit.)
bp   105-107 °C/1 mmHg(lit.)
mp   46-49 °C(lit.)
density   1.344 g/mL at 25 °C(lit.)
storage temp.   2-8°C

Description

Other Notes

Reagent for enantiomeric alcohols, (+)-a-methoxy-a-trifluoromethylphenyleacetyl, and (+)-a-methoxy-a-trifluoromethylphenyleacetamide.

Same product — same quality — now Sigma-Aldrich brand

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Application

Reagent used for the determination of the enantiomeric purity and the absolute configuration of alcohols and amines by NMR; doi:10.1038/nprot.2007.354; Review

General description

Mosher’s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
235.4 °F
Flash Point(C) 
113 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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