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675970 Sigma-Aldrich

Cyclopentyl methyl ether Green Alternative

contains 50 ppm BHT as inhibitor, anhydrous, ≥99.9%

Synonym: CPME



Related Categories Anhydrous Solvents, Greener Solvent Alternatives, Solvent by Type, Solvent Bottles, Solvent Packaging Options,
grade   anhydrous
assay   ≥99.9%
contains   50 ppm BHT as inhibitor
greener alternative product characteristics   Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.
impurities   ≤0.0050% H2O
  ≤50 ppm H2O2
evapn. residue   <0.003%
color   APHA: ≤10
bp   106 °C/760 mmHg
density   0.86 g/mL at 25 °C


Frequently Asked Questions

Frequently Asked Questions are available for this Product.


1, 2 L in Sure/Seal™

100, 12×100 mL in Sure/Seal™


• Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation.
• The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs.
• CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH–DMC and i-PrOH–EtOAc.

Green Alternative to THF, tert-Butyl methyl ether (MTBE), 1,4 Dioxane and other ether solvents

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.

Price and Availability

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
UN 3271 3 / PGII
WGK Germany 
Flash Point(F) 
30.2 °F
Flash Point(C) 
-1 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
What are the features and benefits for using cyclopentyl methyl ether (CPME) over tetrahydrofuran, tert-butylmethyl ether (MTBE), 1,4-dioxane, and other ether solvents?
The features and benefits can be found on page two of the following link: http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Brochure/greener_solvent_alternatives.Par.0001.File.tmp/greener_solvent_alternatives.pdf
What are some of the physical properties of Cyclopentyl methyl ether, Product 675970?
The physical properties of this chemical can be found on page 4 of the following link: http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Brochure/greener_solvent_alternatives.Par.0001.File.tmp/greener_solvent_alternatives.pdf
What is the percentage of peroxides that will form with Cyclopentyl methyl ether, Product 675970?
The percentage of peroxides that will form with this product can be found in the chart on page 4 of the link below: http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Brochure/greener_solvent_alternatives.Par.0001.File.tmp/greener_solvent_alternatives.pdf
Show more questions
Protocols & Articles


Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates

The synthesis of potassium trifluoro(N-methylheteroaryl)borates and their use in cross-coupling reactions with various aryl and heteroaryl halides to construct N-methyl heteroaryl-substituted aromati...
Keywords: Chromatography, Column chromatography, Coupling reactions, Cross couplings

Suzuki-Miyaura Cross-Coupling of Potassium Trifluoro(N-methylheteroaryl)borates with Aryl and Heteroaryl Halides

A new bulky biarylphosphine ligand (L8) has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions than previously possible...
Keywords: Catalysis, Chromatography, Cross couplings, Flash chromatography, Ligands

Related Content

Greener Alternatives Three Categories

A new icon has been added to identify our Greener alternative products. Products with this icon fulfill one of the three criteria.
Keywords: Alternative energy, Ceramics, Environmental, Green chemistry, Materials Science, Nanomaterials, PAGE

Properties of Solvents Table

a. Gant, R., LC/GC 10(7), 515 (1992) 1. At 20 °C 2. At 20 °C +/- 5 °C relative to water at 4 °C 3. At 10mmHg pressure 4. At l=589.32nm
Keywords: Gas chromatography, High performance liquid chromatography

Peer-Reviewed Papers


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